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. 1969 Sep;204(1):15–30. doi: 10.1113/jphysiol.1969.sp008895

Circulatory changes and renin secretion in sheep in response to feeding

J R Blair-West, A H Brook
PMCID: PMC1351590  PMID: 4187459

Abstract

1. The effect of feeding on the circulation, on renin release and on renal function has been examined in the sheep.

2. There was a rapid reduction of plasma volume within 15 min of starting to eat dry feed.

3. This was accompanied by an abrupt rise in systolic blood pressure and by a more gradual and prolonged elevation of heart rate.

4. Within 30 min of feeding there occurred renal conservation of sodium and water which continued for at least 2-3 hr.

5. Renin was released into the circulation of sheep that ate rapidly; slow feeders did not show this response.

6. The rise in plasma renin concentration was inhibited by infusing a solution similar in composition to mixed saliva at a rate that prevented the change in plasma volume.

7. It is concluded that the rapid transfer of sodium and water from the circulation to the rumen via the saliva during ingestion of dry feed is sufficient to activate the renin/angiotensin system.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BARGER A. C., BERLIN R. D., TULENKO J. F. Infusion of aldosterone, 9-alpha-fluorohydrocortisone and antidiuretic hormone into the renal artery of normal and adrenalectomized, unanesthetized dogs: effect on electrolyte and water excretion. Endocrinology. 1958 Jun;62(6):804–815. doi: 10.1210/endo-62-6-804. [DOI] [PubMed] [Google Scholar]
  2. BLAIR-WEST J. R., COGHLAN J. P., DENTON D. A., GODING J. R., WRIGHT R. D. The effect of aldosterone, cortisol, and corticosterone upon the sodium and potassium content of sheep's parotid saliva. J Clin Invest. 1963 Apr;42:484–496. doi: 10.1172/JCI104737. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Barraclough M. A. Dose-dependent opposite effects of angiotensin on renal sodium excretion. Lancet. 1965 Nov 13;2(7420):987–988. doi: 10.1016/s0140-6736(65)92845-x. [DOI] [PubMed] [Google Scholar]
  4. Barraclough M. A., Jones N. F., Marsden C. D. Effect of angiotensin on renal function in the rat. Am J Physiol. 1967 May;212(5):1153–1157. doi: 10.1152/ajplegacy.1967.212.5.1153. [DOI] [PubMed] [Google Scholar]
  5. Blair-West J. R., Coghlan J. P., Denton D. A., Scoggins B. A., Wintour M., Wright R. D. The renin-angiotensin-aldosterone system in sodium depletion. Med J Aust. 1967 Aug 12;2(7):290–293. [PubMed] [Google Scholar]
  6. Blair-West J. R., Coghlan J. P., Denton D. A., Scott D., Wright R. D. The role of aldosterone in renal sodium conservation during sodium depletion. Aust J Exp Biol Med Sci. 1968 Oct;46(5):525–529. doi: 10.1038/icb.1968.160. [DOI] [PubMed] [Google Scholar]
  7. Boyd G. W. The reproducibility and accuracy of plasma volume estimation in the sheep with both 131I gamma globulin and Evan's blue. Aust J Exp Biol Med Sci. 1967 Feb;45(1):51–75. doi: 10.1038/icb.1967.3. [DOI] [PubMed] [Google Scholar]
  8. Brook A. H., Radford H. M., Stacy B. D. The function of antidiuretic hormone in the sheep. J Physiol. 1968 Aug;197(3):723–734. doi: 10.1113/jphysiol.1968.sp008585. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Bunag R. D., Page I. H., McCubbin J. W. Neural stimulation of release of renin. Circ Res. 1966 Oct;19(4):851–858. doi: 10.1161/01.res.19.4.851. [DOI] [PubMed] [Google Scholar]
  10. Cohen E. L., Rovner D. R., Conn J. W. Postural augmentation of plasma renin activity. Importance in diagnosis of renovascular hypertension. JAMA. 1966 Sep 19;197(12):973–978. [PubMed] [Google Scholar]
  11. DENTON D. A. The effect of Na+ depletion on the Na+ :K+ ratio of the parotid saliva of the sheep. J Physiol. 1956 Mar 28;131(3):516–525. doi: 10.1113/jphysiol.1956.sp005479. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. FINE D., MEISELAS L. E., AUERBACH T. The effect of acute hypovolemia on the release of aldosterone and on the renal excretion of sodium. J Clin Invest. 1958 Feb;37(2):232–243. doi: 10.1172/JCI103602. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. GENEST J., BIRON P., KOIW E., NOWACZYNSKI W., CHRETIEN M., BOUCHER R. Adrenocortical hormones in human hypertension and their relation to angiotensin. Circ Res. 1961 May;9:775–791. doi: 10.1161/01.res.9.3.775. [DOI] [PubMed] [Google Scholar]
  14. GOODKIND M. J., BALL W. C., Jr, DAVIS J. O. Effect of chronic hemorrhage on urinary aldosterone-like activity and sodium excretion in dogs. Am J Physiol. 1957 Apr;189(1):181–184. doi: 10.1152/ajplegacy.1957.189.1.181. [DOI] [PubMed] [Google Scholar]
  15. Gill J. R., Bartter F. C. Adrenergic nervous system in sodium metabolism. II. Effects of guanethidine on the renal response to sodium deprivation in normal man. N Engl J Med. 1966 Dec 29;275(26):1466–1471. doi: 10.1056/NEJM196612292752603. [DOI] [PubMed] [Google Scholar]
  16. Gordon R. D., Küchel O., Liddle G. W., Island D. P. Role of the sympathetic nervous system in regulating renin and aldosterone production in man. J Clin Invest. 1967 Apr;46(4):599–605. doi: 10.1172/JCI105561. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Hodge R. L., Lowe R. D., Vane J. R. The effects of alteration of blood-volume on the concentration of circulating angiotensin in anaesthetized dogs. J Physiol. 1966 Aug;185(3):613–626. doi: 10.1113/jphysiol.1966.sp008005. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Lameijer L. D., Soghikian K., de Graeff J. The effect of angiotensin on renal sodium excretion: studies in normal dogs and in dogs with experimental renal artery stenosis. Clin Sci. 1966 Jun;30(3):529–541. [PubMed] [Google Scholar]
  19. Louis W. J., Doyle A. E. The effects of varying doses of angiotensin on renal function and blood pressure in man and dogs. Clin Sci. 1965 Dec;29(3):489–504. [PubMed] [Google Scholar]
  20. MILLS J. N., THOMAS S., WILLIAMSON K. S. The extent of the adrenal influence upon renal electrolyte excretion in the healthy man on a normal diet, and its contribution to the renal changes on standing. J Endocrinol. 1962 Jan;23:365–373. doi: 10.1677/joe.0.0230365. [DOI] [PubMed] [Google Scholar]
  21. Malvin R. L., Vander A. J. Effects of angiotensin infusion on renal function in the unanesthetized rat. Am J Physiol. 1967 Nov;213(5):1205–1208. doi: 10.1152/ajplegacy.1967.213.5.1205. [DOI] [PubMed] [Google Scholar]
  22. PEARCE M. L., NEWMAN E. V. Some postural adjustments of salt and water excretion. J Clin Invest. 1954 Aug;33(8):1089–1094. doi: 10.1172/JCI102981. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. PEART W. S. THE RENIN-ANGIOTENSIN SYSTEM. Pharmacol Rev. 1965 Jun;17:143–182. [PubMed] [Google Scholar]
  24. PICKERING G. ACTION OF RENIN AND ANGIOTENSIN IN THE RENAL HANDLING OF SODIUM AND CHLORIDE IN RABBITS. Can Med Assoc J. 1964 Jan 25;90:256–257. [PMC free article] [PubMed] [Google Scholar]
  25. Pomeranz B. H., Birtch A. G., Barger A. C. Neural contrfl of intrarenal blood flow. Am J Physiol. 1968 Nov;215(5):1067–1081. doi: 10.1152/ajplegacy.1968.215.5.1067. [DOI] [PubMed] [Google Scholar]
  26. SKINNER S. L., MCCUBBIN J. W., PAGE I. H. CONTROL OF RENIN SECRETION. Circ Res. 1964 Jul;15:64–76. doi: 10.1161/01.res.15.1.64. [DOI] [PubMed] [Google Scholar]
  27. STACY B. D., BROOK A. H. ANTIDIURETIC HORMONE ACTIVITY IN SHEEP AFTER FEEDING. Q J Exp Physiol Cogn Med Sci. 1965 Jan;50:65–78. doi: 10.1113/expphysiol.1965.sp001771. [DOI] [PubMed] [Google Scholar]
  28. Stacy B. D., Warner A. C. Balances of water and sodium in the rumen during feeding: osmotic stimulation of sodium absorption in the sheep. Q J Exp Physiol Cogn Med Sci. 1966 Apr;51(2):79–93. doi: 10.1113/expphysiol.1966.sp001843. [DOI] [PubMed] [Google Scholar]
  29. THURAU K., SCHNERMANN J. DIE NATRIUMKONZENTRATION AN DEN MACULA DENSA-ZELLEN ALS REGULIERENDER FAKTOR FUER DAS GLOMERULUMFILTRAT (MIKROPUNKTIONSVERSUCHE) Klin Wochenschr. 1965 Apr 15;43:410–413. doi: 10.1007/BF01483845. [DOI] [PubMed] [Google Scholar]
  30. Ternouth J. H. Changes in the thiosulphate space and some constituents of the blood of sheep after feeding. Res Vet Sci. 1968 Jul;9(4):345–349. [PubMed] [Google Scholar]
  31. Tobian L. Renin release and its role in renal function and the control of salt balance and arterial pressure. Fed Proc. 1967 Jan-Feb;26(1):48–54. [PubMed] [Google Scholar]
  32. VANDER A. J., MILLER R. CONTROL OF RENIN SECRETION IN THE ANESTHETIZED DOG. Am J Physiol. 1964 Sep;207:537–546. doi: 10.1152/ajplegacy.1964.207.3.537. [DOI] [PubMed] [Google Scholar]
  33. Vander A. J. Control of renin release. Physiol Rev. 1967 Jul;47(3):359–382. doi: 10.1152/physrev.1967.47.3.359. [DOI] [PubMed] [Google Scholar]
  34. Webster A. J., Hays F. L. Effects of beta-adrenergic blockade on the heart rate and energy expenditure of sheep during feeding and during acute cold exposure. Can J Physiol Pharmacol. 1968 Jul;46(4):577–583. doi: 10.1139/y68-084. [DOI] [PubMed] [Google Scholar]
  35. de VRIES L., ten HOLT S., van DAATSELAAR J., MULDER A., BORST J. G. Characteristic renal excretion patterns in response to physiological, pathological and pharmacological stimuli. Clin Chim Acta. 1960 Nov;5:915–937. doi: 10.1016/0009-8981(60)90125-x. [DOI] [PubMed] [Google Scholar]

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