Abstract
During the past two years, six patients with systemic mastocytosis have required general or regional anesthesia for operative correction of various surgical problems. Mastocytosis constitutes an extremely difficult problem in diagnosis and management. A large experience with patients with mastocytosis in the Vanderbilt Medical Center in the last decade has enhanced awareness of this disorder and increased its early recognition. The hazardous problems of systemic mastocytosis and the difficulties of its diagnosis and management are summarized and focussed on the increased hazard of those patients with this disease who require various surgical operations. Close collaboration between anesthesiologists, surgeons, and internists in this medical center in the past two years has made it possible to carry six of these patients through anesthesia, operation, and the postoperative period safely and without fatality.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- DEMIS D. J. THE MASTOCYTOSIS SYNDROME: CLINICAL AND BIOLOGICAL STUDIES. Ann Intern Med. 1963 Aug;59:194–206. doi: 10.7326/0003-4819-59-2-194. [DOI] [PubMed] [Google Scholar]
- HAMRIN B. Release of histamine in urticaria pigmentosa. Lancet. 1957 Apr 27;272(6974):867–868. doi: 10.1016/s0140-6736(57)91395-8. [DOI] [PubMed] [Google Scholar]
- Roberts L. J., 2nd, Marney S. R., Jr, Oates J. A. Blockade of the flush associated with metastatic gastric carcinoid by combined histamine H1 and H2 receptor antagonists. Evidence for an important role of H2 receptors in human vasculature. N Engl J Med. 1979 Feb 1;300(5):236–238. doi: 10.1056/NEJM197902013000506. [DOI] [PubMed] [Google Scholar]
- Roberts L. J., 2nd, Sweetman B. J., Lewis R. A., Austen K. F., Oates J. A. Increased production of prostaglandin D2 in patients with systemic mastocytosis. N Engl J Med. 1980 Dec 11;303(24):1400–1404. doi: 10.1056/NEJM198012113032405. [DOI] [PubMed] [Google Scholar]
- Roberts L. J., 2nd, Turk J. W., Oates J. A. Shock syndrome associated with mastocytosis: pharmacologic reversal of the acute episode and therapeutic prevention of recurrent attacks. Adv Shock Res. 1982;8:145–152. [PubMed] [Google Scholar]