Skip to main content
NCBI home page
Annals of Surgery logoLink to Annals of Surgery
. 1983 Aug;198(2):151–158. doi: 10.1097/00000658-198308000-00007

Carcinoma of the colon and rectum--growth rate.

S Bolin, E Nilsson, R Sjödahl
PMCID: PMC1353072  PMID: 6870372

Abstract

Twenty-seven carcinomas of the colon or rectum are presented which could retrospectively be measured on radiographs at two separate occasions. The mean diameter of the tumors at first and second investigations was 35 mm (10-90 mm) and 65 mm (30-110 mm), respectively, and the median interval between these examinations was 11 months (4-91 months). The median linear growth rate was 0.083 mm/day (0.008-0.262 mm/day). The median time for doubling of tumor volume was 130 days (53-1570 days), assuming a three-dimensional pattern of tumor growth. A significant correlation between poor differentiation and high linear growth rate (greater than or equal to 0.1 mm/day) was found. It is suggested that the high growth rate observed in this investigation in comparison with some previous studies may be due to the large size of the tumors and, hence, to their great risk of being malignant already at the first examination.

Full text

PDF
151

Images in this article

156Figs. 6a-c.
on p.156
156Figs. 6a-c.
on p.156
155Figs. 5a and b.
on p.155
157Figs. 7a-c.
on p.157
157Figs. 7a-c.
on p.157

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Burnett K. R., Greenbaum E. I. Rapidly growing carcinoma of the colon. Dis Colon Rectum. 1981 May-Jun;24(4):282–286. doi: 10.1007/BF02641878. [DOI] [PubMed] [Google Scholar]
  2. Ekelund G. R., Pihl B. Mutiple carcinomas of the colon and rectum. Cancer. 1974 Jun;33(6):1630–1634. doi: 10.1002/1097-0142(197406)33:6<1630::aid-cncr2820330624>3.0.co;2-0. [DOI] [PubMed] [Google Scholar]
  3. Ekelund G., Lindström C., Rosengren J. E. Appearance and growth of early carcinomas of the colon-rectum. Acta Radiol Diagn (Stockh) 1974 Nov;15(6):670–679. doi: 10.1177/028418517401500610. [DOI] [PubMed] [Google Scholar]
  4. Gabrielsson N., Granqvist S., Ohlsén H., Sundelin P. Malignancy of colonic polyps. Diagnosis and management. Acta Radiol Diagn (Stockh) 1978;19(3):479–495. doi: 10.1177/028418517801900309. [DOI] [PubMed] [Google Scholar]
  5. Heald R. J., Bussey H. J. Clinical experiences at St. Mark's Hospital with multiple synchronous cancers of the colon and rectum. Dis Colon Rectum. 1975 Jan-Feb;18(1):6–10. doi: 10.1007/BF02587230. [DOI] [PubMed] [Google Scholar]
  6. Morson B. President's address. The polyp-cancer sequence in the large bowel. Proc R Soc Med. 1974 Jun;67(6 Pt 1):451–457. doi: 10.1177/00359157740676P115. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Muto T., Bussey H. J., Morson B. C. The evolution of cancer of the colon and rectum. Cancer. 1975 Dec;36(6):2251–2270. doi: 10.1002/cncr.2820360944. [DOI] [PubMed] [Google Scholar]
  8. Nilsson E., Bolin S., Sjödahl R. Carcinoma of the colon and rectum. Delay in diagnosis. Acta Chir Scand. 1982;148(7):617–622. [PubMed] [Google Scholar]
  9. Silverberg S. G. Focally malignant adenomatous polyps of the colon and rectum. Surg Gynecol Obstet. 1970 Jul;131(1):103–114. [PubMed] [Google Scholar]
  10. Steel G. G., Lamerton L. F. The growth rate of human tumours. Br J Cancer. 1966 Mar;20(1):74–86. doi: 10.1038/bjc.1966.9. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. WELIN S., YOUKER J., SPRATT J. S., Jr THE RATES AND PATTERNS OF GROWTH OF 375 TUMORS OF THE LARGE INTESTINE AND RECTUM OBSERVED SERIALLY BY DOUBLE CONTRAST ENEMA STUDY (MALMOE TECHNIQUE). Am J Roentgenol Radium Ther Nucl Med. 1963 Oct;90:673–687. [PubMed] [Google Scholar]
  12. Welch J. P. Multiple colorectal tumors. An appraisal of natural history and therapeutic options. Am J Surg. 1981 Aug;142(2):274–280. doi: 10.1016/0002-9610(81)90292-0. [DOI] [PubMed] [Google Scholar]

Articles from Annals of Surgery are provided here courtesy of Lippincott, Williams, and Wilkins

RESOURCES