Skip to main content
NCBI home page
Annals of Surgery logoLink to Annals of Surgery
. 1983 Dec;198(6):736–742. doi: 10.1097/00000658-198312000-00012

Polymorphonuclear leukocyte migration abnormalities and their significance in seriously traumatized patients.

E G Maderazo, S D Albano, C L Woronick, A D Drezner, R Quercia
PMCID: PMC1353223  PMID: 6357117

Abstract

Polymorphonuclear leukocyte (PMN) locomotory responses were studied in 24 patients who sustained serious blunt trauma, mostly from motor vehicle accidents. The results showed the presence of a combined cell- and serum-associated locomotory abnormality. The serum abnormality was due to a cell-directed inhibitor, and was present for an average of 3 days. The cell-associated abnormality persisted for approximately 1 week in uninfected patients, and 2 weeks in the infected group. Both mature and immature forms of PMNs contribute to the PMN locomotory dysfunction observed. A significant correlation was observed between the degree of PMN locomotory abnormality or injury severity score and the infection rate. Eighteen infections (six suspected and 12 definite) were observed in 11 of the 24 patients. Twelve (67%) infections involved the lungs. Nine patients (82%) showed evidence of infection by day 6. PMN dysfunction in trauma is associated with increased infection rate and is not due solely to increased numbers of immature forms of PMNs.

Full text

PDF
736

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Alexander J. W., Hegg M., Altemeier W. A. Neutrophil function in selected surgical disorders. Ann Surg. 1968 Sep;168(3):447–458. doi: 10.1097/00000658-196809000-00012. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. BIRKE G., DUNER H., LILJEDAHL S. O., PERNOW B., PLANTIN L. O., TROELL L. Histamine, catechol amines and adrenocortical steroids in burns. Acta Chir Scand. 1958 Jan 31;114(2):87–98. [PubMed] [Google Scholar]
  3. Baker S. P., O'Neill B., Haddon W., Jr, Long W. B. The injury severity score: a method for describing patients with multiple injuries and evaluating emergency care. J Trauma. 1974 Mar;14(3):187–196. [PubMed] [Google Scholar]
  4. Christou N. V., McLean A. P., Meakins J. L. Host defense in blunt trauma: interrelationships of kinetics of anergy and depressed neutrophil function, nutritional status, and sepsis. J Trauma. 1980 Oct;20(10):833–841. doi: 10.1097/00005373-198010000-00003. [DOI] [PubMed] [Google Scholar]
  5. Christou N. V., Meakins J. L. Neutrophil function in surgical patients: two inhibitors of granulocyte chemotaxis associated with sepsis. J Surg Res. 1979 Apr;26(4):355–364. doi: 10.1016/0022-4804(79)90020-9. [DOI] [PubMed] [Google Scholar]
  6. Esmann V. The diabetic leukocyte. Enzyme. 1972;13(1):32–55. [PubMed] [Google Scholar]
  7. Finley P. R., Williams R. J., Lichti D. A., Thies A. C. Evaluation of a new multichannel analyzer, "Astra-8". Clin Chem. 1978 Dec;24(12):2125–2131. [PubMed] [Google Scholar]
  8. Hill H. R., Estensen R. D., Hogan N. A., Quie P. G. Severe staphylococcal disease associated with allergic manifestations, hyperimmunoglobulinemia E, and defective neutrophil chemotaxis. J Lab Clin Med. 1976 Nov;88(5):796–806. [PubMed] [Google Scholar]
  9. Maderazo D. G., Ward P. A., Woronick C. L., Quintiliani R. Partial characterization of a cell-directed inhibitor of leukotaxis in human serum. J Lab Clin Med. 1977 Jan;89(1):190–199. [PubMed] [Google Scholar]
  10. Maderazo E. G., Anton T. F., Ward P. A. Serum-associated inhibition of leukotaxis in humans with cancer. Clin Immunol Immunopathol. 1978 Feb;9(2):166–176. doi: 10.1016/0090-1229(78)90068-5. [DOI] [PubMed] [Google Scholar]
  11. Maderazo E. G., Woronick C. L. Micropore filter assay of human granulocyte locomotion: problems and solutions. Clin Immunol Immunopathol. 1978 Oct;11(2):196–211. doi: 10.1016/0090-1229(78)90044-2. [DOI] [PubMed] [Google Scholar]
  12. Maderazo E. G., Woronick C. L., Ward P. A. Leukokinesis-enhancing factor in human serum: partial characterization and relationship to disorders of leukocyte migration. Clin Immunol Immunopathol. 1979 Apr;12(4):382–395. doi: 10.1016/0090-1229(79)90043-6. [DOI] [PubMed] [Google Scholar]
  13. Schimpff S. C., Miller R. M., Polkavetz S., Hornick R. B. Infection in the severely traumatized patient. Ann Surg. 1974 Mar;179(3):352–357. doi: 10.1097/00000658-197403000-00017. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Van Epps D. E., Strickland R. G., Williams R. C., Jr Inhibitors of leukocyte chemotaxis in alcoholic liver disease. Am J Med. 1975 Aug;59(2):200–207. doi: 10.1016/0002-9343(75)90354-x. [DOI] [PubMed] [Google Scholar]
  15. Woolfson A. M., Heatley R. V., Allison S. P. Insulin to inhibit protein catabolism after injury. N Engl J Med. 1979 Jan 4;300(1):14–17. doi: 10.1056/NEJM197901043000104. [DOI] [PubMed] [Google Scholar]
  16. Woronick C. L., Malnick J., Maderazo E. G. Cell-directed inhibitor of human leukocyte locomotion. Identification of immunoglobulin G as a cell-directed inhibitor in normal human serum. J Lab Clin Med. 1981 Jul;98(1):58–67. [PubMed] [Google Scholar]
  17. Zigmond S. H. A modified millipore filter method for assaying polymorphonuclear leukocyte locomotion and chemotaxis. Antibiot Chemother (1971) 1974;19:126–145. doi: 10.1159/000395428. [DOI] [PubMed] [Google Scholar]

Articles from Annals of Surgery are provided here courtesy of Lippincott, Williams, and Wilkins

RESOURCES