Skip to main content
NCBI home page
Annals of Surgery logoLink to Annals of Surgery
. 1984 Jan;199(1):75–78. doi: 10.1097/00000658-198401000-00013

Renal allograft survival in patients with positive B cell crossmatch to their donor.

C E Morrow, D E Sutherland, D S Fryd, H Noreen, M Segall, F H Bach, J S Najarian
PMCID: PMC1353261  PMID: 6362583

Abstract

B cell crossmatches were performed at cold (4 C) and warm (22 C and 37 C) temperatures on 193 renal allograft recipients with negative T cell crossmatches to their donor; 152 of the patients were also tested for autoantibody to autologous B cells. Fifty-six (29%) had a positive B cell crossmatch (21 cold, 35 warm); 14 were autoantibody positive, 23 autoantibody negative, and 19 were not tested for autoantibody. There were no differences in HLA-A, B, C, or DR antigen disparity between the B cell positive (14, 0 DR mismatch; 25, 1 DR mismatch; 9, 0 DR mismatch) and the B cell negative group (40, 0 DR mismatch; 57, 1 DR mismatch; 13, 2 DR mismatch). Similarly, age, diabetic status, and number and type of pretransplant blood transfusions were comparable between B cell positive and negative groups. Although there were no hyperacute rejections, 2-year actuarial graft survival was significantly lower in the B cell positive group, regardless of donor source, graft number, or temperature of reaction. Patients with a positive B cell crossmatch, presumably due to demonstrable autoantibody, may have better graft survival rates than patients with a positive B cell crossmatch and no autoantibody.

Full text

PDF
75

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Ahern A. T., Artruc S. B., DellaPelle P., Cosimi A. B., Russell P. S., Colvin R. B., Fuller T. C. Hyperacute rejection of HLA-AB-identical renal allografts associated with B lymphocyte and endothelial reactive antibodies. Transplantation. 1982 Jan;33(1):103–106. doi: 10.1097/00007890-198201000-00023. [DOI] [PubMed] [Google Scholar]
  2. Ayoub G., Park M. S., Terasaki P. I., Iwaki Y., Opelz G. B cell antibodies and crossmatching. Transplantation. 1980 Mar;29(3):227–229. doi: 10.1097/00007890-198003000-00013. [DOI] [PubMed] [Google Scholar]
  3. Ayoub G., Terasaki P. HLA-DR matching in multicenter, single-typing laboratory data. Transplantation. 1982 May;33(5):515–517. doi: 10.1097/00007890-198205000-00010. [DOI] [PubMed] [Google Scholar]
  4. B-cell cross-match in renal transplantation. Lancet. 1977 Jul 30;2(8031):241–242. [PubMed] [Google Scholar]
  5. Coxe-Gilliland R., Cross D. E. Warm B-cell antibodies and DRw matching: their influence on transplant outcome at a single center. Transplant Proc. 1981 Mar;13(1 Pt 2):945–948. [PubMed] [Google Scholar]
  6. Ettenger R. B., Uittenbogaart C. H., Pennisi A. J., Malekzadeh M. H., Fine R. N. Long-term cadaver allograft survival in the recipient with a positive B lymphocyte crossmatch. Transplantation. 1979 May;27(5):315–318. doi: 10.1097/00007890-197905000-00005. [DOI] [PubMed] [Google Scholar]
  7. GEHAN E. A. A GENERALIZED WILCOXON TEST FOR COMPARING ARBITRARILY SINGLY-CENSORED SAMPLES. Biometrika. 1965 Jun;52:203–223. [PubMed] [Google Scholar]
  8. Lobo P. I., Wertervelt F. B., Jr, Rudolf L. E. Kidney transplantatability across a positive cross-match. Cross-match assays and distribution of B lymphocytes in donor tissues. Lancet. 1977 Apr 30;1(8018):925–928. doi: 10.1016/s0140-6736(77)92223-1. [DOI] [PubMed] [Google Scholar]
  9. Morris P. J., Ting A., Oliver D. Renal transplantation in the presence of a positive crossmatch. Transplant Proc. 1978 Jun;10(2):467–469. [PubMed] [Google Scholar]
  10. Myburgh J. A., Smit J. A. B-cell antibodies and clinical kidney transplantation. Transplant Proc. 1978 Sep;10(3):599–601. [PubMed] [Google Scholar]
  11. Soulillou J. P., de Mouzon A., Peyrat M. A., Guenel J. Role of anti-donor B lymphocyte antibodies in definitive allograft rejection. Transplant Proc. 1979 Mar;11(1):770–775. [PubMed] [Google Scholar]
  12. Ting A., Morris P. J. Positive crossmatch transplants--safe or not? Transplant Proc. 1981 Sep;13(3):1544–1546. [PubMed] [Google Scholar]
  13. d'Apice A. J., Tait B. D. Improved survival and function of renal transplants with positive B cell crossmatches. Transplantation. 1979 May;27(5):324–328. doi: 10.1097/00007890-197905000-00007. [DOI] [PubMed] [Google Scholar]

Articles from Annals of Surgery are provided here courtesy of Lippincott, Williams, and Wilkins

RESOURCES