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. 1977 Oct;271(2):549–565. doi: 10.1113/jphysiol.1977.sp012014

A quantitative study of C-mechanoreceptors in hairy skin of the cat.

A Iggo, H H Kornhuber
PMCID: PMC1353586  PMID: 926006

Abstract

1. Single C-mechanorecptor afferent units were examined by recording from fibres dissected from the saphenous nerves of cats anaesthetized with chloralose. The receptive fields, averaging 4 X 3 mm when 10-50 X threshold stimuli were used, were in the hairy skin of the leg and foot. 2. The extent and excitability of receptor terminals was tested by two-and three-point field studies. The excitability of terminals in one part of the field of a unit could be depressed without affecting the excitability of terminals elsewhere in the field. 3. The afferent units could be excited by both inward and outward movement of the stimulus probe, in appropriate conditions; that is, there was non-directional sensitivity. 4. After-discharge was found to depend on restorative movements of the skin, not on a persistence of the response of the receptor to the original movement. 5. The response to mechanical stimulation was slowly adapting with two time constants and the stimulus-response relationship was exactly described by a power function, with exponents ranging from 0-6 to 1-3. 6. The C-mechanoreceptors could be depressed by rapidly repeated or prolonged mechanical stimulation and the effect was confined to the excited terminals.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Beck P. W., Handwerker H. O., Zimmermann M. Nervous outflow from the cat's foot during noxious radiant heat stimulation. Brain Res. 1974 Mar 8;67(3):373–386. doi: 10.1016/0006-8993(74)90488-0. [DOI] [PubMed] [Google Scholar]
  2. Bessou P., Burgess P. R., Perl E. R., Taylor C. B. Dynamic properties of mechanoreceptors with unmyelinated (C) fibers. J Neurophysiol. 1971 Jan;34(1):116–131. doi: 10.1152/jn.1971.34.1.116. [DOI] [PubMed] [Google Scholar]
  3. Bessou P., Perl E. R. Response of cutaneous sensory units with unmyelinated fibers to noxious stimuli. J Neurophysiol. 1969 Nov;32(6):1025–1043. doi: 10.1152/jn.1969.32.6.1025. [DOI] [PubMed] [Google Scholar]
  4. Brown A. G., Iggo A. A quantitative study of cutaneous receptors and afferent fibres in the cat and rabbit. J Physiol. 1967 Dec;193(3):707–733. doi: 10.1113/jphysiol.1967.sp008390. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Cauna N. The fine morphology of the sensory receptor organs in the auricle of the rat. J Comp Neurol. 1969 May;136(1):81–98. doi: 10.1002/cne.901360106. [DOI] [PubMed] [Google Scholar]
  6. Cauna N. The free penicillate nerve endings of the human hairy skin. J Anat. 1973 Jul;115(Pt 2):277–288. [PMC free article] [PubMed] [Google Scholar]
  7. Chambers M. R., Andres K. H., von Duering M., Iggo A. The structure and function of the slowly adapting type II mechanoreceptor in hairy skin. Q J Exp Physiol Cogn Med Sci. 1972 Oct;57(4):417–445. doi: 10.1113/expphysiol.1972.sp002177. [DOI] [PubMed] [Google Scholar]
  8. DOUGLAS W. W., RITCHIE J. M. Nonmedullated fibres in the saphenous nerve which signal touch. J Physiol. 1957 Dec 31;139(3):385–399. doi: 10.1113/jphysiol.1957.sp005899. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. DOUGLAS W. W., RITCHIE J. M., STRAUB R. W. The role of nonmyelinated fibres in signalling cooling of the skin. J Physiol. 1960 Feb;150:266–283. doi: 10.1113/jphysiol.1960.sp006386. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Franz D. N., Iggo A. Conduction failure in myelinated and non-myelinated axons at low temperatures. J Physiol. 1968 Dec;199(2):319–345. doi: 10.1113/jphysiol.1968.sp008656. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. HENSEL H., IGGO A., WITT I. A quantitative study of sensitive cutaneous thermoreceptors with C afferent fibres. J Physiol. 1960 Aug;153:113–126. doi: 10.1113/jphysiol.1960.sp006522. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Hahn J. F. Thermal-mechanical stimulus interactions in low-threshold C-fiber mechanoreceptors of cat. Exp Neurol. 1971 Dec;33(3):607–617. doi: 10.1016/0014-4886(71)90131-2. [DOI] [PubMed] [Google Scholar]
  13. Handwerker H. O., Neher K. D. Characteristics of C-fibre receptors in the cat's foot responding to stepwise increase of skin temperature ot noxious levels. Pflugers Arch. 1976 Sep 30;365(2-3):221–229. doi: 10.1007/BF01067022. [DOI] [PubMed] [Google Scholar]
  14. Hensel H., Iggo A. Analysis of cutaneous warm and cold fibres in primates. Pflugers Arch. 1971;329(1):1–8. doi: 10.1007/BF00586896. [DOI] [PubMed] [Google Scholar]
  15. IGGO A. Cutaneous heat and cold receptors with slowly conducting (C) afferent fibres. Q J Exp Physiol Cogn Med Sci. 1959 Oct;44:362–370. doi: 10.1113/expphysiol.1959.sp001417. [DOI] [PubMed] [Google Scholar]
  16. IGGO A. Cutaneous mechanoreceptors with afferent C fibres. J Physiol. 1960 Jul;152:337–353. doi: 10.1113/jphysiol.1960.sp006491. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. IGGO A. The electrophysiological identification of single nerve fibres, with particular reference to the slowest-conducting vagal afferent fibres in the cat. J Physiol. 1958 Jun 18;142(1):110–126. doi: 10.1113/jphysiol.1958.sp006002. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Iggo A. Cutaneous thermoreceptors in primates and sub-primates. J Physiol. 1969 Feb;200(2):403–430. doi: 10.1113/jphysiol.1969.sp008701. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Iggo A., Muir A. R. The structure and function of a slowly adapting touch corpuscle in hairy skin. J Physiol. 1969 Feb;200(3):763–796. doi: 10.1113/jphysiol.1969.sp008721. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Iggo A., Ogawa H. Primate cutaneous thermal nociceptors. J Physiol. 1971 Jul;216(2):77P–78P. [PubMed] [Google Scholar]
  21. WITT I., GRIFFIN J. P. Afferent cutaneous C-fibre reactivity to repeated thermal stimuli. Nature. 1962 May 26;194:776–777. doi: 10.1038/194776a0. [DOI] [PubMed] [Google Scholar]
  22. Zotterman Y. Touch, pain and tickling: an electro-physiological investigation on cutaneous sensory nerves. J Physiol. 1939 Feb 14;95(1):1–28. doi: 10.1113/jphysiol.1939.sp003707. [DOI] [PMC free article] [PubMed] [Google Scholar]

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