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. 1977 Nov;272(3):613–632. doi: 10.1113/jphysiol.1977.sp012063

A quantitative description of the pattern of breathing during steady-state CO2 inhalation in man, with special emphasis on expiration

D J C Cunningham, W N Gardner
PMCID: PMC1353645  PMID: 592205

Abstract

1. Quantitative data on the pattern of breathing in normal men and women (Gardner, 1977) have been used to derive expressions that are based on known physiological mechanisms.

2. The relations between the applied chemical drive to breathing (expressed as ΔPA, CO2 in high O2) and the several components of the volume—time patterns described in the companion paper were examined. Neither mean tidal volume (V̄T), nor mean inspiratory nor mean expiratory times (T̄I, T̄E) were uniquely related to the chemical drive across the breakpoint, which could be demonstrated in two and suspected in the third of these plots.

3. Mean inspiratory flow (V̄T/T̄I) was linearly related to PA, CO2 over the whole range and, like minute ventilation (V̇̄), showed no breakpoint. The mean relation was V̄T/T̄I = 0·11 (PA, CO2 — 35·2). V̄T/T̄I was highly correlated with V̇̄; in individuals with healthy lungs and under relatively stable conditions of compliance and resistance it may be accepted as a wholly inspiratory alternative to V̇̄ as an index, on the efferent side, of the total prevailing chemical drive.

4. The description of the relation between T̄I and V̄T was essentially the same as that of Clark & Euler (1972): in range 1, T̄I = either 1·29 - 0·07 V̄T or the constant 1·24 sec, and in range 2, T̄I = 0·65/(V̄T — 0·88) + 0·59.

5. Expiration was described by an equation based on the inverse linkage between T̄E and chemical drive and the direct link between both mean and breath-by-breath values of TI and TE: T̄E = pT̄I + q/(drive — r) in which p was 0·64 ± 0·09, q was 11·1 ± 2·64 sec. (torr CO2)-1 and r was -2·73 ± 1·09 torr CO2. All three parameters were necessary for an adequate description.

6. It is argued that the first term of the TE equation represents influences related to lung volume exerted through the vagus, and that the second represents the effects of over-all chemical stimulation exerted through other pathways.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bartoli A., Bystrzycka E., Guz A., Jain S. K., Noble M. I., Trenchard D. Studies of the pulmonary vagal control of central respiratory rhythm in the absence of breathing movements. J Physiol. 1973 Apr;230(2):449–465. doi: 10.1113/jphysiol.1973.sp010197. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Bartoli A., Cross B. A., Guz A., Huszczuk A., Jeffries R. The effect of varying tidal volume on the associated phrenic motoneurone output:studies of vagal and chemical feedback. Respir Physiol. 1975 Nov;25(2):135–155. doi: 10.1016/0034-5687(75)90093-6. [DOI] [PubMed] [Google Scholar]
  3. Bartoli A., Cross B. A., Guz A., Jain S. K., Noble M. I., Trenchard D. W. The effect of carbon dioxide in the airways and alveoli on ventilation; a vagal reflex studied in the dog. J Physiol. 1974 Jul;240(1):91–109. doi: 10.1113/jphysiol.1974.sp010601. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Bradley G. W., Noble M. I., Trenchard D. The direct effect on pulmonary stretch receptor discharge produced by changing lung carbon dioxide concentration in dogs on cardiopulmonary bypass and its action on breathing. J Physiol. 1976 Oct;261(2):359–373. doi: 10.1113/jphysiol.1976.sp011563. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Bradley G. W., von Euler C., Marttila I., Roos B. A model of the central and reflex inhibition of inspiration in the cat. Biol Cybern. 1975 Aug 8;19(2):105–116. doi: 10.1007/BF00364107. [DOI] [PubMed] [Google Scholar]
  6. Callanan D., Dixon M., Widdicombe J. G. The acute effects of SO2 on pulmonary mechanics, breathing patterns and pulmonary vagal afferent receptors in the rabbit. J Physiol. 1975 May;247(1):23P–24P. [PubMed] [Google Scholar]
  7. Clark F. J., von Euler C. On the regulation of depth and rate of breathing. J Physiol. 1972 Apr;222(2):267–295. doi: 10.1113/jphysiol.1972.sp009797. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Cunningham D. J., Drysdale D. B., Gardner W. N., Jensen J. I., Petersen E. S., Whipp B. J. Very small, very short-latency changes in human breathing induced by step changes of alveolar gas composition. J Physiol. 1977 Apr;266(2):411–421. doi: 10.1113/jphysiol.1977.sp011774. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Davis J. N., Stagg D. Interrelationships of the volume and time components of individual breaths in resting man. J Physiol. 1975 Feb;245(2):481–498. doi: 10.1113/jphysiol.1975.sp010857. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Drysdale D. B., Ward S. A. The reflex latency of inspiratory and expiratory responses to an alternate-breath oscillation of alveolar PCO2 in man [proceedings]. J Physiol. 1976 Sep;260(2):41P–42P. [PubMed] [Google Scholar]
  11. Gardner W. N. Proceedings: The pattern of breathing following step changes of alveolar PCO2 in man. J Physiol. 1974 Oct;242(2):75P–76P. [PubMed] [Google Scholar]
  12. Gardner W. N. The relation between tidal volume and inspiratory and expiratory times during steady-state carbon dioxide inhalation in man. J Physiol. 1977 Nov;272(3):591–611. doi: 10.1113/jphysiol.1977.sp012062. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Gautier H., Remmers J. E., Bartlett D., Jr Control of the duration of expiration. Respir Physiol. 1973 Jul;18(2):205–221. doi: 10.1016/0034-5687(73)90051-0. [DOI] [PubMed] [Google Scholar]
  14. Grunstein M. M., Younes M., Milic-Emili J. Control of tidal volume and respiratory frequency in anesthetized cats. J Appl Physiol. 1973 Oct;35(4):463–476. doi: 10.1152/jappl.1973.35.4.463. [DOI] [PubMed] [Google Scholar]
  15. Hey E. N., Lloyd B. B., Cunningham D. J., Jukes M. G., Bolton D. P. Effects of various respiratory stimuli on the depth and frequency of breathing in man. Respir Physiol. 1966;1(2):193–205. doi: 10.1016/0034-5687(66)90016-8. [DOI] [PubMed] [Google Scholar]
  16. Kay J. D., Petersen E. S., Vejby-Christensen H. Mean and breath-by-breath pattern of breathing in man during steady-state exercise. J Physiol. 1975 Oct;251(3):657–669. doi: 10.1113/jphysiol.1975.sp011114. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Knox C. K. Characteristics of inflation and deflation reflexes during expiration of the cat. J Neurophysiol. 1973 Mar;36(2):284–295. doi: 10.1152/jn.1973.36.2.284. [DOI] [PubMed] [Google Scholar]
  18. Matthews A. W., Howell J. B. The rate of isometric inspiratory pressure development as a measure of responsiveness to carbon dioxide in man. Clin Sci Mol Med. 1975 Jul;49(1):57–68. doi: 10.1042/cs0490057. [DOI] [PubMed] [Google Scholar]
  19. Milic-Emili J., Grunstein M. M. Drive and timing components of ventilation. Chest. 1976 Jul;70(1 Suppl):131–133. doi: 10.1378/chest.70.1_supplement.131. [DOI] [PubMed] [Google Scholar]
  20. NIELSEN M., SMITH H. Studies on the regulation of respiration in acute hypoxia; with a appendix on respiratory control during prolonged hypoxia. Acta Physiol Scand. 1952 Feb 12;24(4):293–313. doi: 10.1111/j.1748-1716.1952.tb00847.x. [DOI] [PubMed] [Google Scholar]
  21. Patrick J. M., Howard A. The influence of age, sex, body size and lung size on the control and pattern of breathing during CO 2 inhalation in Caucasians. Respir Physiol. 1972 Dec;16(3):337–350. doi: 10.1016/0034-5687(72)90063-1. [DOI] [PubMed] [Google Scholar]
  22. Remmers J. E. Analysis of ventilatory response. Chest. 1976 Jul;70(1 Suppl):134–137. doi: 10.1378/chest.70.1_supplement.134. [DOI] [PubMed] [Google Scholar]
  23. Ward S. A., Cunningham D. J. Separation of the inspiratory and expiratory reflex effects of alternate-breath oscillation of PACO2 during hypoxia. Respir Physiol. 1977 May;29(3):379–390. doi: 10.1016/0034-5687(77)90011-1. [DOI] [PubMed] [Google Scholar]
  24. von Euler C., Wexler I., Herrero F. Control mechanisms determining rate and depth of respiratory movements. Respir Physiol. 1970 Jul;10(1):93–108. doi: 10.1016/0034-5687(70)90030-7. [DOI] [PubMed] [Google Scholar]

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