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. 1977 Nov;272(3):769–778. doi: 10.1113/jphysiol.1977.sp012072

Fatigue of long duration in human skeletal muscle after exercise.

R H Edwards, D K Hill, D A Jones, P A Merton
PMCID: PMC1353654  PMID: 592214

Abstract

1. After severe muscular contraction in man recovery of force is largely complete in a few minutes, but is not wholly so for many hours. The long-lasting element of fatigue is found to occur primarily for low frequencies of stimulation (e.g. 20/sec), and is much less pronounced, or absent, at high frequencies (80/sec). The twitch force is an unreliable measure of the state of fatigue. 2. The long-lasting element of fatigue is not due to depletion of high-energy phosphate nor is it due to failure of electrical activity as recorded from surface electrodes. It is probably the result of an impairment of the process of excitation-contraction coupling. Its practical importance for man could be significant as an explanation of the subjective feelings of weakness following exercise.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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