Fig. 2.

Alterations of mRNA gene expression of the neuroinflammatory signaling pathways NF-κB (A), IκBα (B), COX-2 (C), iNOS (D), TLR2 (E) and NLRP3 (F), caused by icv injections of QA and GA in the cerebral cortex of WT and Gcdh^−/− mice on PND8. Data are presented as mean ± standard deviation (SD), with n = 3–5 animals per group. Statistical analysis was performed using two-way ANOVA followed by the Tukey’s post hoc test (*P < 0.05, **P < 0.01, ***P < 0.001, differences from PBS + PBS + PBS; ^#P < 0.05, ^##P < 0.01, ^###P < 0.001, differences from PBS + PBS + GA; ^$$$P < 0.001 differences from PBS + QA + GA; ^@P < 0.05, ^@@@P < 0.001 differences from genotype)