Abstract
The role of bile salts and refluxed duodenal content in the pathogenesis of acute gastric ulcers in the shocked rat were examined. The addition of cholestyramine to duodenal contents inhibits their ulcerogenic action in the stomach of rats challenged by an acid load, (100 mEq/l Hcl) and subsequently bled to a mean blood pressure of 20 mm Hg. Also, bile duct ligation 2 days before the reflux procedure and subsequent shock also inhibited ulcer formation. An ex vivo rat gastric chamber was used to further demonstrate that the “barrier” breaking action of bovine sodium taurocholate and sodium lauryl sulphate could be prevented by cholestyramine. Cholestyramine also inhibited the usual rapid depression of the transmucosal potential difference (PD) produced by both of these agents. It is concluded that cholestyramine protects the gastric mucosa from ulceration by blocking the barrier breaking action of bile salts in duodenal chyme.
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- Black R. B., Rhodes J., Davies G. T., Gravelle H., Sweetnam P. A controlled clinical trial of cholestyramine in the treatment of gastric ulcer. Gastroenterology. 1971 Dec;61(6):821–825. [PubMed] [Google Scholar]
- Braun S. A., Samson R. H., Norton L., Eiseman B. Bile reflux in experimental stress ulcer. Surgery. 1973 Apr;73(4):521–524. [PubMed] [Google Scholar]
- Capper W. M. Factors in the pathogenesis of gastric ulcer. Hunterian lecture delivered at the Royal College of Surgeons of England on 18th January 1966. Ann R Coll Surg Engl. 1967 Jan;40(1):21–35. [PMC free article] [PubMed] [Google Scholar]
- Cotran R. S., Suter E. R., Majno G. The use of colloidal carbon as a tracer for vascular injury. A review. Vasc Dis. 1967 Apr;4(2):107–127. [PubMed] [Google Scholar]
- DUPLESSIS D. J. PATHOGENESIS OF GASTRIC ULCERATION. Lancet. 1965 May 8;1(7393):974–978. doi: 10.1016/s0140-6736(65)91214-6. [DOI] [PubMed] [Google Scholar]
- Davenport H. W. Destruction of the gastric mucosal barrier by detergents and urea. Gastroenterology. 1968 Feb;54(2):175–181. [PubMed] [Google Scholar]
- DenBesten L., Hamza K. N. Effect of bile salts on ionic permeability of canine gastric mucosa during experimental shock. Gastroenterology. 1972 Mar;62(3):417–424. [PubMed] [Google Scholar]
- Fisher R. S., Cohen S. Pyloric-sphincter dysfunction in patients with gastric ulcer. N Engl J Med. 1973 Feb 8;288(6):273–276. doi: 10.1056/NEJM197302082880601. [DOI] [PubMed] [Google Scholar]
- Geall M. G., Phillips S. F., Summerskill W. H. Profile of gastric potential difference in man. Effects of aspirin, alcohol, bile, and endogenous acid. Gastroenterology. 1970 Apr;58(4):437–443. [PubMed] [Google Scholar]
- Hamza K. N., DenBesten L. Bile salts producing stress ulcers during experimental shock. Surgery. 1972 Feb;71(2):161–167. [PubMed] [Google Scholar]
- Ivey K. J., DenBesten L., Clifton J. A. Effect of bile salts on ionic movement across the human gastric mucosa. Gastroenterology. 1970 Nov;59(5):683–690. [PubMed] [Google Scholar]
- Mersereau W. A., Hinchey E. J. Effect of gastric acidity on gastric ulceration induced by hemorrhage in the rat, utilizing a gastric chamber technique. Gastroenterology. 1973 Jun;64(6):1130–1135. [PubMed] [Google Scholar]
- Rhodes J., Barnardo D. E., Phillips S. F., Rovelstad R. A., Hofmann A. F. Increased reflux of bile into the stomach in patients with gastric ulcer. Gastroenterology. 1969 Sep;57(3):241–252. [PubMed] [Google Scholar]