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. 1974 Jun;179(6):889–895. doi: 10.1097/00000658-197406000-00012

Effect of Changes in Inspired Oxygen Tension on Wound Metabolism

Timo Vihersaari, Jaakko Kivisaari, Juha Niinikoski
PMCID: PMC1355920  PMID: 4835508

Abstract

This work was prompted by earlier findings of the beneficial effect of increased oxygen supply on wound healing. Enzyme activities in the limiting step of glycolysis, citric acid cycle and pentose phosphate cycle were determined in cellulose sponge implants of rats chronically, breathing 12% O2, air or 55% O2. Respiratory gas tensions and concentrations of pyruvate and lactate were measured in wound fluid aspirated from the implants. Significant portions of repair tissue exist in conditions of extremely low oxygen tension. Probably because all added oxygen is readily consumed, the wound fluid PO2 increased only slightly in hyperoxic environment. The wound PCO2 increased in parallel with the inspired PO2, probably due to enhanced production of carbon dioxide. Hyperoxia shifted the wound metabolism from anaerobic towards aerobic glycolysis. This occurred concurrently with activation of citric acid cycle. Succinic dehydrogenase, a linking enzyme between citric acid cycle and electron transfer chain, also increased with increasing oxygen tension. This oxygen-induced metabolical change has been previously observed in many other tissues.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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