Abstract
1. The influence of repeatedly raising the body temperature by radiant heat to a level at which acclimatization to heat is normally acquired was investigated in two series of experiments, the first without the subjects sweating, the second with sweating.
2. In a second investigation local sweat-gland activity was induced by drug injections on successive days without raising the body temperature.
3. These experiments show that the increased sweating capacity characteristic of acclimatization to heat is a result of sweat-gland activity and does not appear to be induced by or to depend on an elevated body temperature.
4. Secretory activity results in a loss of glycogen from sweat-gland cells on the first day of heat exposure but not after the glands have been `trained' by acclimatization to heat.
5. The state of acclimatization has no influence on the threshold concentration of acetylcholine required to elicit sweating when injected intradermally.
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Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- BENZINGER T. H. Peripheral cold- and central warm-reception, main origins of human thermal discomfort. Proc Natl Acad Sci U S A. 1963 Jun;49:832–839. doi: 10.1073/pnas.49.6.832. [DOI] [PMC free article] [PubMed] [Google Scholar]
- BENZINGER T. H. The diminution of thermoregulatory sweating during cold-reception at the skin. Proc Natl Acad Sci U S A. 1961 Oct 15;47:1683–1688. doi: 10.1073/pnas.47.10.1683. [DOI] [PMC free article] [PubMed] [Google Scholar]
- CHALMERS T. M., KEELE C. A. The nervous and chemical control of sweating. Br J Dermatol. 1952 Feb;64(2):43–54. doi: 10.1111/j.1365-2133.1952.tb16160.x. [DOI] [PubMed] [Google Scholar]
- DOBSON R. L. The effect of repeated episodes of profuse sweating on the human eccrine sweat glands. J Invest Dermatol. 1960 Sep;35:195–198. [PubMed] [Google Scholar]
- FOX R. H., GOLDSMITH R., HAMPTON I. F., LEWIS H. E. THE NATURE OF THE INCREASE IN SWEATING CAPACITY PRODUCED BY HEAT ACCLIMATIZATION. J Physiol. 1964 Jun;171:368–376. doi: 10.1113/jphysiol.1964.sp007382. [DOI] [PMC free article] [PubMed] [Google Scholar]
- FOX R. H., GOLDSMITH R., KIDD D. J., LEWIS H. E. Blood flow and other thermoregulatory changes with acclimatization to heat. J Physiol. 1963 May;166:548–562. doi: 10.1113/jphysiol.1963.sp007122. [DOI] [PMC free article] [PubMed] [Google Scholar]
- SCHWARTZ I. L., THAYSEN J. H. Excretion of sodium and potassium in human sweat. J Clin Invest. 1956 Jan;35(1):114–120. doi: 10.1172/JCI103245. [DOI] [PMC free article] [PubMed] [Google Scholar]
- URBACH F., SHELLEY W. B. A rapid and simple method for obtaining punch biopsies without anesthesia. J Invest Dermatol. 1951 Sep;17(3):131–134. doi: 10.1038/jid.1951.72. [DOI] [PubMed] [Google Scholar]
- WEINER J. S., VAN HEYNINGEN R. E. Observations on lactate content of sweat. J Appl Physiol. 1952 Mar;4(9):734–744. doi: 10.1152/jappl.1952.4.9.734. [DOI] [PubMed] [Google Scholar]