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. 1966 May;184(2):418–432. doi: 10.1113/jphysiol.1966.sp007923

Concentration of radioiodide by the uterus of the rat and the relationship to blastocyst implantation

K Brown-Grant
PMCID: PMC1357569  PMID: 5921838

Abstract

1. When pregnant rats are ovariectomized early in pregnancy and treated with progesterone a raised uterus—plasma concentration ratio (U/P ratio) for radio-iodide is observed at the usual stage of pregnancy (days 3, 4 and 5) but is not followed by implantation. When delayed implantation is induced by the administration of oestradiol it is not preceded by a rise in the U/P ratio for 131I.

2. Similar findings are obtained when implantation is delayed by concurrent lactation in rats mated at the post-partum oestrus.

3. Ovariectomy early in pregnancy without progesterone treatment prevents the rise in U/P and oviduct—plasma (O/P) ratio for 131I that normally occurs.

4. Administration of progesterone to intact or ovariectomized non-pregnant rats produces a raised U/P and O/P ratio for 131I; oestrogen may inhibit this response. The simplest explanation of these results is a direct action of progesterone on the uterus.

5. By gross dissection it was possible to show that the region of high iodide concentration in the rat uterus is the endometrium.

6. No evidence of a concentration of iodide in the uterus or oviduct of the pregnant rabbit was obtained.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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