Skip to main content
PMC home page
The Journal of Physiology logoLink to The Journal of Physiology
. 1966 Mar;183(2):369–377. doi: 10.1113/jphysiol.1966.sp007871

The effect of inhibitors on intestinal transfer of glucose and fluid

Joan F Detheridge, J Matthews, D H Smyth
PMCID: PMC1357583  PMID: 5942817

Abstract

1. The effect of various experimental conditions has been studied on the transfer of hexoses and fluid by everted sacs of rat small intestine.

2. The existence of glucose-dependent and glucose-independent mechanisms has been confirmed; the energy for the former comes from the citric acid cycle, and for the latter from either the glycolytic or pentose cycle.

3. The energy for glucose transfer against a concentration gradient can come from metabolism of glucose by some route other than the citric acid cycle, or it may come from the citric acid cycle.

4. Two-stage transfer of glucose is discussed as a possible explanation of the results.

Full text

PDF
369

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BARRY B. A., MATTHEWS J., SMYTH D. H. Transfer of glucose and fluid by different parts of the small intestine of the rat. J Physiol. 1961 Jul;157:279–288. doi: 10.1113/jphysiol.1961.sp006721. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. BARRY R. J., DIKSTEIN S., MATTHEWS J., SMYTH D. H., WRIGHT E. M. ELECTRICAL POTENTIALS ASSOCIATED WITH INTESTINAL SUGAR TRANSFER. J Physiol. 1964 Jun;171:316–338. doi: 10.1113/jphysiol.1964.sp007379. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. DAHLQVIST A. Determination of maltase and isomaltase activities with a glucose-oxidase reagent. Biochem J. 1961 Sep;80:547–551. doi: 10.1042/bj0800547. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Dickens F., Weil-Malherbe H. Metabolism of normal and tumour tissue: A note on the metabolism of medulla of kidney. Biochem J. 1936 Apr;30(4):659–660. doi: 10.1042/bj0300659. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. HUGGETT A. S., NIXON D. A. Use of glucose oxidase, peroxidase, and O-dianisidine in determination of blood and urinary glucose. Lancet. 1957 Aug 24;273(6991):368–370. doi: 10.1016/s0140-6736(57)92595-3. [DOI] [PubMed] [Google Scholar]
  6. LEVIN R. J., SMYTH D. H. THE EFFECT OF THE THYROID GLAND ON INTESTINAL ABSORPTION OF HEXOSES. J Physiol. 1963 Dec;169:755–769. doi: 10.1113/jphysiol.1963.sp007294. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. NEWEY H., PARSONS B. J., SMYTH D. H. The site of action of phlorrhizin in inhibiting intestinal absorption of glucose. J Physiol. 1959 Oct;148:83–92. doi: 10.1113/jphysiol.1959.sp006274. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. SMYTH D. H., TAYLOR C. B. Transfer of water and solutes by an in vitro intestinal preparation. J Physiol. 1957 May 23;136(3):632–648. doi: 10.1113/jphysiol.1957.sp005788. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. WILSON T. H., WISEMAN G. The use of sacs of everted small intestine for the study of the transference of substances from the mucosal to the serosal surface. J Physiol. 1954 Jan;123(1):116–125. doi: 10.1113/jphysiol.1954.sp005036. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from The Journal of Physiology are provided here courtesy of The Physiological Society

RESOURCES