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. 1990 Feb;211(2):202–210. doi: 10.1097/00000658-199002000-00013

Immunologic effects of arginine supplementation in tumor-bearing and non-tumor-bearing hosts.

J V Reynolds 1, J M Daly 1, J Shou 1, R Sigal 1, M M Ziegler 1, A Naji 1
PMCID: PMC1357965  PMID: 2301998

Abstract

Supplemental dietary arginine has anti-tumor properties but the degree and mechanisms are unclear. In non-tumor-bearing CBA/J mice (n = 60), 1% arginine supplementation significantly enhanced thymic weight, spleen cell mitogenesis, and interferon-activated natural killer cell activity; no further enhancement was observed with 2% or 4% supplementation. Supplemental 1% arginine, when compared with 1.7% glycine, enhanced interferon-induced natural killer cell activity, lymphokine-activated killer cell generation, and macrophage cytotoxicity. In A/J mice (n = 420), bearing either a moderately immunogenic (C1300) or weakly immunogenic (TBJ) murine neuroblastoma, 1% arginine significantly (p less than 0.05) retarded tumor growth and prolonged median survival time compared with glycine or no supplementation. Dietary arginine enhanced T-cell function and significantly increased responsiveness to autologous C1300 tumor in a mixed lymphocyte tumor cell culture (MLTC). The immunomodulatory effects of arginine provide nutritional and immunologic support of the tumor-bearing host and may be helpful when given concommitant with immunotherapy.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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