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. 1990 Oct;212(4):551–558. doi: 10.1097/00000658-199010000-00017

Surgical aspects of sclerosing cholangitis. Results in 178 patients.

F M Martin 1, R L Rossi 1, F W Nugent 1, F J Scholz 1, R L Jenkins 1, W D Lewis 1, M Gagner 1, E Foley 1, J W Braasch 1
PMCID: PMC1358296  PMID: 2222020

Abstract

Of 178 patients with sclerosing cholangitis treated since 1950, 88 patients had associated inflammatory bowel disease, 72 had no such history, and 18 had iatrogenic injury or stone disease. A total of 233 biliary operations were performed, with a 75% rate of temporary improvement after initial operation. Subsequent operations resulted in a lower success rate and a higher mortality rate. Radiologic findings included predominant extrahepatic, intrahepatic, and diffuse disease in 29%, 28%, and 43% of patients, respectively; no survival differences were noted. Seventy-five of one hundred three deaths (73%) were related to liver failure, bleeding, or sepsis. Of 14 patients undergoing portosystemic shunt, 13 died of surgical complications or related disease. Orthotopic liver transplantation was performed in 16 patients and resulted in eight deaths, mainly in patients who had previously undergone extensive surgical treatment. No survival differences were seen between the patients with inflammatory bowel disease, those without the condition, or those who had colectomy. Surgical treatment in patients with sclerosing cholangitis should be minimized. Orthotopic liver transplantation should be offered as the treatment of choice for patients with portal hypertension, refractory cholangitis, advanced cirrhosis, or progressive liver failure.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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