Skip to main content
NCBI home page
Annals of Surgery logoLink to Annals of Surgery
. 1991 Mar;213(3):222–226. doi: 10.1097/00000658-199103000-00007

The potential role of postoperative hepatic artery chemotherapy in patients with high-risk hepatomas.

T Nonami 1, K Isshiki 1, H Katoh 1, W Kishimoto 1, A Harada 1, A Nakao 1, H Takagi 1
PMCID: PMC1358331  PMID: 1847795

Abstract

The relationship between operative findings of hepatoma and the postoperative prognosis was studied to clarify indications for adjuvant hepatic arterial chemotherapy after hepatectomy. The results of adjuvant hepatic arterial chemotherapy using 0.4 mg/kg of doxorubicin and 0.12 mg/kg of mitomycin C and infusion of 5-fluorouracil were reported. One hundred sixty patients who had undergone hepatectomy for hepatoma were studied. In the operative findings of hepatoma, with a surgical margin of less than 10 mm, intrahepatic metastasis, tumor embolus in the second or more proximal branch of the portal vein, or lack of capsule formation related to the prognosis were the risk factors for recurrence. In 132 patients with these risk factors the survival rate of 19 patients with adjuvant arterial chemotherapy was significantly higher than for the 113 patients without it. Adjuvant hepatic arterial chemotherapy thus may be an effective therapy and should be studied prospectively in patients undergoing hepatectomy for high-risk hepatoma.

Full text

PDF
222

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Chlebowski R. T., Chan K. K., Tong M. J., Weiner J. M., Ryden V. M., Bateman J. R. Adriamycin and methyl-CCNU combination therapy in hepatocellular carcinoma: clinical and pharmacokinetic aspects. Cancer. 1981 Sep 1;48(5):1088–1095. doi: 10.1002/1097-0142(19810901)48:5<1088::aid-cncr2820480507>3.0.co;2-w. [DOI] [PubMed] [Google Scholar]
  2. Ekberg H., Tranberg K. G., Andersson R., Jeppsson B., Bengmark S. Major liver resection: perioperative course and management. Surgery. 1986 Jul;100(1):1–8. [PubMed] [Google Scholar]
  3. Falkson G., Coetzer B. J. Application and results of different chemotherapy regimens in primary liver malignancies. Recent Results Cancer Res. 1986;100:103–111. doi: 10.1007/978-3-642-82635-1_13. [DOI] [PubMed] [Google Scholar]
  4. Hwang T. L., Chen M. F., Lee T. Y., Chen T. J., Lin D. Y., Liaw Y. F. Resection of hepatocellular carcinoma after transcatheter arterial embolization. Reevaluation of the advantages and disadvantages of preoperative embolization. Arch Surg. 1987 Jul;122(7):756–759. doi: 10.1001/archsurg.1987.01400190022004. [DOI] [PubMed] [Google Scholar]
  5. Kanematsu T., Matsumata T., Takenaka K., Yoshida Y., Higashi H., Sugimachi K. Clinical management of recurrent hepatocellular carcinoma after primary resection. Br J Surg. 1988 Mar;75(3):203–206. doi: 10.1002/bjs.1800750305. [DOI] [PubMed] [Google Scholar]
  6. Konno T., Maeda H., Iwai K., Maki S., Tashiro S., Uchida M., Miyauchi Y. Selective targeting of anti-cancer drug and simultaneous image enhancement in solid tumors by arterially administered lipid contrast medium. Cancer. 1984 Dec 1;54(11):2367–2374. doi: 10.1002/1097-0142(19841201)54:11<2367::aid-cncr2820541111>3.0.co;2-f. [DOI] [PubMed] [Google Scholar]
  7. Lin T. Y., Lee C. S., Chen K. M., Chen C. C. Role of surgery in the treatment of primary carcinoma of the liver: a 31-year experience. Br J Surg. 1987 Sep;74(9):839–842. doi: 10.1002/bjs.1800740931. [DOI] [PubMed] [Google Scholar]
  8. Nagao T., Inoue S., Goto S., Mizuta T., Omori Y., Kawano N., Morioka Y. Hepatic resection for hepatocellular carcinoma. Clinical features and long-term prognosis. Ann Surg. 1987 Jan;205(1):33–40. doi: 10.1097/00000658-198701000-00006. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Nonami T. [Systemic hemodynamics and oxygen metabolism after hepatectomy--effect of hyperdynamic systemic circulatory support on postoperative prognosis]. Nihon Geka Gakkai Zasshi. 1985 Feb;86(2):148–159. [PubMed] [Google Scholar]
  10. Okamoto E., Tanaka N., Yamanaka N., Toyosaka A. Results of surgical treatments of primary hepatocellular carcinoma: some aspects to improve long-term survival. World J Surg. 1984 Jun;8(3):360–366. doi: 10.1007/BF01655077. [DOI] [PubMed] [Google Scholar]
  11. Reed M. L., Vaitkevicius V. K., Al-Sarraf M., Vaughn C. B., Singhakowinta A., Sexon-Porte M., Izbicki R., Baker L., Straatsma G. W. The practicality of chronic hepatic artery infusion therapy of primary and metastatic hepatic malignancies: ten-year results of 124 patients in a prospective protocol. Cancer. 1981 Jan 15;47(2):402–409. doi: 10.1002/1097-0142(19810115)47:2<402::aid-cncr2820470231>3.0.co;2-b. [DOI] [PubMed] [Google Scholar]
  12. Sesto M. E., Vogt D. P., Hermann R. E. Hepatic resection in 128 patients: a 24-year experience. Surgery. 1987 Nov;102(5):846–851. [PubMed] [Google Scholar]
  13. Sheen M. C., Huang T. J., Sheen P. C., Ho Y. H., Sheu H. M., Ou S. C., Chen C. Y., Wu C. C. Continuous intra-arterial infusion chemotherapy of hepatoma. Taiwan Yi Xue Hui Za Zhi. 1983 Mar;82(3):389–398. [PubMed] [Google Scholar]
  14. Shibata J., Fujiyama S., Sato T., Kishimoto S., Fukushima S., Nakano M. Hepatic arterial injection chemotherapy with cisplatin suspended in an oily lymphographic agent for hepatocellular carcinoma. Cancer. 1989 Oct 15;64(8):1586–1594. doi: 10.1002/1097-0142(19891015)64:8<1586::aid-cncr2820640805>3.0.co;2-e. [DOI] [PubMed] [Google Scholar]
  15. Takayasu K., Muramatsu Y., Moriyama N., Yamada T., Hasegawa H., Okazaki N., Hirohashi S., Tsugane S. [Clinico-radiological evaluation of recurrence in the residual liver following hepatectomy in 97 patients with hepatocellular carcinoma]. Nihon Shokakibyo Gakkai Zasshi. 1987 Jul;84(7):1424–1432. [PubMed] [Google Scholar]

Articles from Annals of Surgery are provided here courtesy of Lippincott, Williams, and Wilkins

RESOURCES