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. 1991 Feb;213(2):137–142. doi: 10.1097/00000658-199102000-00008

The role of calcium ions and calcium channel entry blockers in experimental ischemia-reperfusion-induced liver injury.

R J Nauta 1, E Tsimoyiannis 1, M Uribe 1, D B Walsh 1, D Miller 1, A Butterfield 1
PMCID: PMC1358386  PMID: 1992940

Abstract

Verapamil administered before treatment, but not after treatment, had a beneficial effect on a 90-minute warm ischemia-reperfusion rat liver injury model. The possible activation of proteases converting the xanthine dehydrogenase to xanthine oxidase, the significant mitochondrial calcium loading during the ischemic period, and the potentiation of calcium and oxygen-derived free radicals to promote injury to mitochondria are mechanisms supported by this study, based on both histologic observations and on the pattern of enzyme leak after the acute ischemic event.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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