Skip to main content
PMC home page
Annals of Surgery logoLink to Annals of Surgery
. 1991 Sep;214(3):328–338. doi: 10.1097/00000658-199109000-00015

The role of multimodality therapy in soft-tissue sarcoma.

M F Brennan 1, E S Casper 1, L B Harrison 1, M H Shiu 1, J Gaynor 1, S I Hajdu 1
PMCID: PMC1358657  PMID: 1929613

Abstract

Soft-tissue sarcomas are uncommon malignancies. The development during a period of 8 years, in one institution, of a prospective data base incorporating more than 1600 patients with these tumors is described. The most common sites for occurrence are the extremities, but they can occur in any of the soft tissues of the body. Liposarcoma and leiomyosarcoma are the most common histopathologic conditions identified. Prognostic factors for both recurrence and survival include site, histopathology, size, grade, and adequacy of resection. A prospective randomized trial of the use of adjuvant radiation by the brachytherapy technique in extremity lesions has shown a decrease in local recurrence, but no impact on survival. Eligible patients not randomized to the trial show no difference in local recurrence or survival, regardless of whether they received adjuvant radiation.

Full text

PDF
328

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Arbeit J. M., Hilaris B. S., Brennan M. F. Wound complications in the multimodality treatment of extremity and superficial truncal sarcomas. J Clin Oncol. 1987 Mar;5(3):480–488. doi: 10.1200/JCO.1987.5.3.480. [DOI] [PubMed] [Google Scholar]
  2. Brennan M. F., Hilaris B., Shiu M. H., Lane J., Magill G., Friedrich C., Hajdu S. I. Local recurrence in adult soft-tissue sarcoma. A randomized trial of brachytherapy. Arch Surg. 1987 Nov;122(11):1289–1293. doi: 10.1001/archsurg.1987.01400230075014. [DOI] [PubMed] [Google Scholar]
  3. Cance W. G., Brennan M. F., Dudas M. E., Huang C. M., Cordon-Cardo C. Altered expression of the retinoblastoma gene product in human sarcomas. N Engl J Med. 1990 Nov 22;323(21):1457–1462. doi: 10.1056/NEJM199011223232105. [DOI] [PubMed] [Google Scholar]
  4. Chang H. R., Gaynor J., Tan C., Hajdu S. I., Brennan M. F. Multifactorial analysis of survival in primary extremity liposarcoma. World J Surg. 1990 Sep-Oct;14(5):610–618. doi: 10.1007/BF01658804. [DOI] [PubMed] [Google Scholar]
  5. Collin C. F., Friedrich C., Godbold J., Hajdu S., Brennan M. F. Prognostic factors for local recurrence and survival in patients with localized extremity soft-tissue sarcoma. Semin Surg Oncol. 1988;4(1):30–37. doi: 10.1002/ssu.2980040108. [DOI] [PubMed] [Google Scholar]
  6. Collin C., Godbold J., Hajdu S., Brennan M. Localized extremity soft tissue sarcoma: an analysis of factors affecting survival. J Clin Oncol. 1987 Apr;5(4):601–612. doi: 10.1200/JCO.1987.5.4.601. [DOI] [PubMed] [Google Scholar]
  7. Collin C., Hadju S. I., Godbold J., Shiu M. H., Hilaris B. I., Brennan M. F. Localized, operable soft tissue sarcoma of the lower extremity. Arch Surg. 1986 Dec;121(12):1425–1433. doi: 10.1001/archsurg.1986.01400120075013. [DOI] [PubMed] [Google Scholar]
  8. Collin C., Hajdu S. I., Godbold J., Friedrich C., Brennan M. F. Localized operable soft tissue sarcoma of the upper extremity. Presentation, management, and factors affecting local recurrence in 108 patients. Ann Surg. 1987 Apr;205(4):331–339. doi: 10.1097/00000658-198704000-00001. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Devereux D. F., Kent H., Brennan M. F. Time dependent effects of adriamycin and x-ray therapy on wound healing in the rat. Cancer. 1980 Jun 1;45(11):2805–2810. doi: 10.1002/1097-0142(19800601)45:11<2805::aid-cncr2820451115>3.0.co;2-#. [DOI] [PubMed] [Google Scholar]
  10. Donohue J. H., Collin C., Friedrich C., Godbold J., Hajdu S. I., Brennan M. F. Low-grade soft tissue sarcomas of the extremities. Analysis of risk factors for metastasis. Cancer. 1988 Jul 1;62(1):184–193. doi: 10.1002/1097-0142(19880701)62:1<184::aid-cncr2820620128>3.0.co;2-c. [DOI] [PubMed] [Google Scholar]
  11. Fletcher J. A., Kozakewich H. P., Hoffer F. A., Lage J. M., Weidner N., Tepper R., Pinkus G. S., Morton C. C., Corson J. M. Diagnostic relevance of clonal cytogenetic aberrations in malignant soft-tissue tumors. N Engl J Med. 1991 Feb 14;324(7):436–442. doi: 10.1056/NEJM199102143240702. [DOI] [PubMed] [Google Scholar]
  12. Kilman J. W., Clatworthy H. W., Jr, Newton W. A., Jr, Grosfeld J. L. Reasonable surgery for rhabdomyosarcoma: a study of 67 cases. Ann Surg. 1973 Sep;178(3):346–351. doi: 10.1097/00000658-197309000-00014. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Malpas J. S., Freeman J. E., Paxton A., Smith J. W., Stansfeld A. G., Wood C. B. Radiotherapy and adjuvant combination chemotherapy for childhood rhabdomyosarcoma. Br Med J. 1976 Jan 31;1(6004):247–249. doi: 10.1136/bmj.1.6004.247. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Ormsby M. V., Hilaris B. S., Nori D., Brennan M. F. Wound complications of adjuvant radiation therapy in patients with soft-tissue sarcomas. Ann Surg. 1989 Jul;210(1):93–99. doi: 10.1097/00000658-198907000-00014. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Russell W. O., Cohen J., Enzinger F., Hajdu S. I., Heise H., Martin R. G., Meissner W., Miller W. T., Schmitz R. L., Suit H. D. A clinical and pathological staging system for soft tissue sarcomas. Cancer. 1977 Oct;40(4):1562–1570. doi: 10.1002/1097-0142(197710)40:4<1562::aid-cncr2820400428>3.0.co;2-6. [DOI] [PubMed] [Google Scholar]
  16. Wunder J. S., Czitrom A. A., Kandel R., Andrulis I. L. Analysis of alterations in the retinoblastoma gene and tumor grade in bone and soft-tissue sarcomas. J Natl Cancer Inst. 1991 Feb 6;83(3):194–200. doi: 10.1093/jnci/83.3.194. [DOI] [PubMed] [Google Scholar]

Articles from Annals of Surgery are provided here courtesy of Lippincott, Williams, and Wilkins

RESOURCES