Abstract
Background
Patient engagement is a cornerstone of safe healthcare delivery. Understanding the factors that influence patients’ willingness to participate in safety practices is essential for developing effective patient-centered safety interventions. This study explores the determinants influencing patients’ intentions to engage in safety practices, using the Theory of Planned Behavior (TPB).
Objective
To assess the impact of attitudes, subjective norms, perceived behavioral control, and risk perception on patients’ behavioral intentions to remind healthcare providers about hand hygiene and report missing identification bracelets.
Methods
A single-center cross-sectional correlational study was conducted at King Saud Medical City, Riyadh. Using convenience sampling, a structured Arabic questionnaire based on TPB was administered to 465 hospitalized patients. Data were analyzed using SPSS v24 with descriptive, Spearman correlation, and multiple linear regression analyses.
Results
Perceived behavioral control was the strongest predictor of behavioral intention for both hand hygiene (β = 0.612, p < 0.001) and identification-related practices (β = 0.563, p < 0.001). For hand hygiene, subjective norms (β = 0.277, p < 0.001) and attitude (β = 0.162, p = 0.001) were positively associated with intention, whereas risk perception showed a small negative association (β = −0.114, p = 0.014). For identification, risk perception (β = 0.252, p < 0.001) and attitude (β = 0.105, p < 0.001) were positively associated with intention; subjective norms were not significant. The models explained 81.1% and 84.3% of the variance, respectively.
Conclusion
TPB-related factors were strongly associated with patients’ behavioral intentions to engage in the two safety practices studied. Higher perceived behavioral control showed the most consistent association with intention. These findings may inform the development and future testing of patient empowerment, education, and communication interventions; however, the cross-sectional design does not establish that such interventions improve actual patient behavior.
Keywords: patient engagement, patient safety, theory of planned behavior, perceived behavioral control, hand hygiene, patient identification
Plain Language Summary
What is Already Known on this Topic
Patient engagement is increasingly recognized as a key component of safehealthcare delivery. Previous studies have shown that patients cancontribute to preventing healthcare-associated harm, particularlywhen they are encouraged to speak up about safety concerns. However,limited research has focused on the psychosocial factors thatinfluence patients’ willingness to participate in safetypractices—especially in the context of hand hygiene and patientidentification—and most existing evidence originates from Westernhealthcare settings. Evidence from Middle Eastern healthcare settingsremains particularly limited.
What this Study Adds
This study applies the Theory of Planned Behavior (TPB) to examine howattitudes, subjective norms, perceived behavioral control, and riskperception influence patients’ intentions to engage in safetypractices. The findings reveal that perceived behavioral control isthe strongest predictor of patients’ willingness to remindproviders about hand hygiene and report missing identificationbracelets. The study also highlights differing impacts of riskperception depending on the safety behavior examined. The findingsfurther demonstrate the usefulness of TPB in explaining patientengagement behaviors within a Saudi healthcare context.
How this Study Might Affect Research, Practice, or Policy
These findings support the development of targeted patient empowermentinterventions to enhance perceived control and normalize patientinvolvement in safety practices. The study may inform healthcarepolicies that integrate structured communication strategies, stafftraining, and educational campaigns to foster a culture of safetypartnership. It also opens new directions for research exploringbehavioral determinants of patient engagement across culturalcontexts.
Introduction
Patient engagement is increasingly recognized as a vital element of safe, people-centered healthcare. Global campaigns such as the WHO’s “Patients for Patient Safety” have emphasized the role patients can play in improving safety outcomes. Consequently, healthcare systems worldwide have introduced programs focused on education, innovation, and safety culture development.1 The World Health Organization (WHO) defines patient safety as the prevention and reduction of risks, errors, and harm associated with healthcare delivery.2˒3 Achieving this requires structured organizational support, including teamwork, clear protocols, and effective use of health information technology.4
Recent studies advocate for active patient involvement in safety initiatives such as hand hygiene and identification verification.5 Engaging patients as partners fosters shared responsibility for safer care. However, despite global emphasis, many patients remain unaware of their role in preventing medical errors.6˒7 Saudi evidence also indicates a need to strengthen patient participation: a multi-hospital study of 1569 inpatients found that approximately 5% reported witnessing one patient-safety event and 2.3% reported witnessing two or three events.8 In a Saudi public hospital, patient-identification improvement work also documented recurring misidentification incidents and demonstrated that identification remains a practical safety priority.9 These findings underscore the importance of examining how patients can be supported to participate in safety practices in the Saudi context.
Recent research has highlighted the growing importance of patient involvement in promoting healthcare safety. Patients who feel informed, supported, and encouraged to participate are more likely to engage in behaviors that contribute to safer care. Previous studies have shown that patient participation can enhance communication with healthcare professionals and strengthen safety-related practices.6˒10 However, active involvement is often influenced by psychological and social factors. For example, Buregyeya et al reported that some patients were reluctant to remind healthcare workers about hand hygiene because they feared negative reactions or damaging their relationship with providers.11 These findings suggest that understanding the factors that influence patients’ willingness to participate is essential for developing effective strategies that promote patient engagement in safety practices.
This study addresses that gap by applying the Theory of Planned Behavior (TPB), which posits that intention is shaped by attitudes, subjective norms, and perceived behavioral control.12 Risk perception was included as an additional construct because perceived susceptibility or severity can influence motivation to undertake protective health behavior and has been incorporated into extended TPB models.13 The two target behaviors—reminding providers to perform hand hygiene and notifying staff when an identification bracelet is missing—were selected because they are observable, patient-initiated safety actions represented in the validated instrument adapted for this study.6 We hypothesized that more favorable attitudes, stronger subjective norms, greater perceived behavioral control, and higher risk perception would be associated with stronger behavioral intentions to engage in these safety practices.
Methodology
This study was conducted at King Saud Medical City (R1), a major tertiary care hospital located in Riyadh, Saudi Arabia. The setting provided access to a diverse population of inpatients, allowing for the assessment of patient intention to engage in safety-related practices within a real-world clinical environment.
A convenience sampling method was used to recruit eligible participants from various inpatient units. This pragmatic approach was selected to enable recruitment of hospitalized patients who were clinically available and able to complete the questionnaire during the study period; however, it may introduce selection bias because participants who were available and willing to respond may differ from other inpatients. Participants were recruited from different inpatient departments to obtain demographic and clinical diversity. Participants were included if they were hospitalized patients of either gender who were able to understand and respond to the questionnaire. A total of 465 eligible patients completed the study questionnaire.
Patient and Public Involvement
Patients and the public were not involved in the design, conduct, reporting, or dissemination plans of this research.
Ethical Considerations
This study was reviewed and approved by the Institutional Review Board of King Saud Medical City (Approval Number: H1R1-20-FEB-25-2). The study was conducted in accordance with the principles of the Declaration of Helsinki. Written informed consent was obtained from all participants prior to data collection. For participants younger than 18 years of age, written informed consent was obtained from their parents or legal guardians before participation. Participation was voluntary, and individuals were informed of their right to withdraw from the study at any time without penalty. All collected data were treated with strict confidentiality and used solely for research purposes.
Data Collection
Data were collected using a structured questionnaire adapted from a validated instrument originally developed by Davis et al (2012) to assess patients’ readiness to engage in safety practices based on the Theory of Planned Behavior (TPB).6 Permission to use and adapt the instrument was obtained from the original authors.
The questionnaire consisted of five constructs: attitude toward safety practices, subjective norms, perceived behavioral control, risk perception, and behavioral intention. To ensure linguistic and cultural appropriateness, the questionnaire was translated into Arabic using a forward–backward translation process conducted by bilingual experts. The translated version was pilot-tested for clarity, relevance, and comprehensibility, and feedback was used to refine the wording of several items. All items were rated on a 5-point Likert scale ranging from 1 (“Strongly disagree”) to 5 (“Strongly agree”). The Arabic version demonstrated acceptable internal consistency, with Cronbach’s alpha coefficients exceeding 0.70 for all subscales.
Data were analyzed using the Statistical Package for the Social Sciences (SPSS), version 24. Descriptive statistics, including means, standard deviations, frequencies, and percentages, summarized participant characteristics and study variables. Spearman’s rho was used to examine associations because the study variables were derived from Likert-scale responses and a rank-based measure was considered appropriate for the correlation analysis. Multiple linear regression analyses were then used to identify predictors of behavioral intention for hand hygiene and patient-identification practices.
Results
The study sample consisted of 465 participants. The largest age group was 31–50 years (37.6%), followed by participants aged 18–30 years (26.9%). Participants aged 51–70 years represented 20.9%, while those under 18 and over 70 years accounted for 7.1% and 7.5%, respectively. Regarding gender, 52.3% of respondents were male and 47.7% were female. In terms of educational attainment, the largest proportion had completed high school (24.9%), followed by those with bachelor’s degrees (18.5%) and those reporting other educational qualifications (20.2%). Illiterate participants accounted for 10.3% of the sample.
Most participants were married (65.8%), whereas 26.0%were single, 3.4%divorced, and 4.7%widowed. Regarding employment status, 37.0%were employed, 25.8%unemployed, 10.3%retired, and 26.9%selected “other”. In terms of job type, the highest proportion worked in the private sector (33.3%), followed by the government sector (24.5%), freelance work (21.9%), and part-time employment (20.2%). The demographic characteristics of the study participants are presented in Table 1.
Table 1.
Demographic Characteristics of the Study Sample (N = 465)
| Age | Frequency | Percent |
| Under 18 | 33 | 7.1 |
| 18–30 | 125 | 26.9 |
| 31–50 | 175 | 37.6 |
| 51–70 | 97 | 20.9 |
| Over 70 | 35 | 7.5 |
| Total | 465 | 100 |
| Gender | Frequency | Percent |
| Male | 243 | 52.3 |
| Female | 222 | 47.7 |
| Total | 465 | 100 |
| Qualification | Frequency | Percent |
| Illiterate | 48 | 10.3 |
| Intermediate school | 57 | 12.3 |
| High school | 116 | 24.9 |
| Diploma | 64 | 13.8 |
| Bachelor | 86 | 18.5 |
| Others | 94 | 20.2 |
| Total | 465 | 100 |
| Marital Status | Frequency | Percent |
| Married | 306 | 65.8 |
| Single | 121 | 26 |
| Divorced | 16 | 3.4 |
| Widowed | 22 | 4.7 |
| Total | 465 | 100 |
| Employment Status | Frequency | Percent |
| Employed | 172 | 37 |
| Unemployed | 120 | 25.8 |
| Retired | 48 | 10.3 |
| Others | 125 | 26.9 |
| Total | 465 | 100 |
| Job | Frequency | Percent |
| Government | 114 | 24.5 |
| Private | 155 | 33.3 |
| Freelancer | 102 | 21.9 |
| Part time | 94 | 20.2 |
| Total | 465 | 100 |
As shown in Table 2, participants’ overall attitude toward patient safety practices had a moderate mean score (M = 3.10, SD = 1.44). Regarding specific safety behaviors, subjective norms toward hand hygiene were relatively low (M = 2.93, SD = 1.51), whereas subjective norms toward identification bracelet use were higher (M = 3.59, SD = 1.48).
Table 2.
Descriptive Statistics for Study Variables (N = 465)
| Dimensions | N | Mean | SD |
|---|---|---|---|
| Attitude toward safety practices | 465 | 3.10 | 1.44 |
| Subjective Norms Toward Hand hygiene | 465 | 2.93 | 1.51 |
| Subjective Norms Toward Identification | 465 | 3.59 | 1.48 |
| Perceived Behavioral Control toward hand hygiene | 465 | 3.10 | 1.49 |
| Perceived Behavioral Control toward identification | 465 | 3.65 | 1.48 |
| Behavioral Intention toward hand hygiene | 465 | 2.96 | 1.58 |
| Behavioral Intention toward Identification | 465 | 3.64 | 1.48 |
| Risk Perception toward hand hygiene | 465 | 3.09 | 1.46 |
| Risk Perception toward Identification | 465 | 3.50 | 1.44 |
Similarly, perceived behavioral control was stronger for identification-related actions (M = 3.65, SD = 1.48) than for hand hygiene (M = 3.10, SD = 1.49). This pattern was also reflected in participants’ behavioral intentions, with the intention to ask healthcare providers about hand hygiene scoring lower (M = 2.96, SD = 1.58) than the intention to notify staff about identification bracelet issues (M = 3.64, SD = 1.48).
Risk perception followed a similar pattern. Participants perceived greater risk associated with misidentification (M = 3.50, SD = 1.44) than with hospital-acquired infections related to poor hand hygiene (M = 3.09, SD = 1.46). Overall, higher mean scores were consistently observed for identification-related practices compared with hand hygiene-related practices across most study variables. The between-behavior differences shown in Table 2 are descriptive; no inferential test was performed to compare hand-hygiene and identification-related mean scores because such a comparison was not a prespecified study objective.
The results presented in Table 3 showed statistically significant positive correlations (p < 0.01) between all predictor variables and patients’ behavioral intentions to engage in both hand hygiene and identification-related safety practices.
Table 3.
Spearman’s Correlation Between Predictor Variables and Behavioral Intentions Toward Patient Safety Practices (N = 465)
| Predictor Variables | Behavioral Intention | |||
|---|---|---|---|---|
| Hand Hygiene | Identification | |||
| r | P | r | P | |
| Attitude toward safety practices | 0.814 | < 0.01 | 0.732 | < 0.01 |
| Subjective Norms Toward Hand hygiene | 0.808 | < 0.01 | 0.635 | < 0.01 |
| Subjective Norms Toward Identification | 0.598 | < 0.01 | 0.833 | < 0.01 |
| Perceived Behavioral Control toward hand hygiene | 0.877 | < 0.01 | 0.73 | < 0.01 |
| Perceived Behavioral Control toward identification | 0.606 | < 0.01 | 0.87 | < 0.01 |
| Risk Perception toward hand hygiene | 0.756 | < 0.01 | 0.705 | < 0.01 |
| Risk Perception toward Identification | 0.665 | < 0.01 | 0.811 | < 0.01 |
For hand hygiene-related behaviors, there was a strong positive correlation between attitude toward safety practices and behavioral intention (r = 0.814, p < 0.01). Similarly, a significant correlation was found with subjective norms toward hand hygiene (r = 0.808, p < 0.01). Notably, perceived behavioral control demonstrated the strongest correlation with behavioral intention (r = 0.877, p < 0.01), followed by risk perception toward hand hygiene (r = 0.756, p < 0.01).
For identification-related practices, subjective norms (r = 0.833, p < 0.01), perceived behavioral control (r = 0.870, p < 0.01), and risk perception (r = 0.811, p < 0.01) were all strongly and significantly correlated with behavioral intention. Attitude toward safety practices was also positively associated (r = 0.732, p < 0.01).
Overall, all predictor variables demonstrated significant positive correlations with behavioral intentions across both safety practices, with perceived behavioral control showing the strongest associations.
According to Table 4, the results revealed statistically significant and strong positive correlations among the predictor variables themselves. For subjective norms, there was a strong positive correlation with perceived behavioral control toward both hand hygiene (r = 0.806, p < 0.01) and patient identification (r = 0.907, p < 0.01).
Table 4.
Spearman’s Correlations Among Predictor Variables (N = 465)
| Predictor (1) | Predictor (2) | r | p | N |
|---|---|---|---|---|
| Perceived Behavioral Control (Hand Hygiene) | Subjective Norms (Hand Hygiene) | 0.806** | < 0.01 | 465 |
| Perceived Behavioral Control (Identification) | Subjective Norms (Identification) | 0.907** | < 0.01 | 465 |
| Risk Perception (Hand Hygiene) | Attitude toward Safety Practices | 0.876** | < 0.01 | 465 |
| Risk Perception (Identification) | Attitude toward Safety Practices | 0.750** | < 0.01 | 465 |
Note: ** Correlation is significant at p < 0.01 (two-tailed).
In addition, risk perception was strongly correlated with attitude toward safety practices for both hand hygiene (r = 0.876, p < 0.01) and patient identification (r = 0.750, p < 0.01). Overall, the findings indicate substantial positive associations among the predictor variables, suggesting that these constructs are closely related within the study population.
A multiple linear regression analysis was conducted to assess the predictive value of attitude toward safety practices, subjective norms, perceived behavioral control, and risk perception on patients’ behavioral intention to ask healthcare providers about hand hygiene. The model was statistically significant, F(4, 460) = 492.210, p < 0.001, and accounted for 81.1% of the variance in behavioral intention (R2 = 0.811, Adjusted R2 = 0.809).
Among the predictors, perceived behavioral control demonstrated the strongest standardized effect (β = 0.612, p < 0.001), followed by subjective norms (β = 0.277, p < 0.001) and attitude toward safety practices (β = 0.162, p = 0.001). Risk perception was also a significant predictor but showed a small negative association with hand-hygiene intention (β = −0.114, p = 0.014), despite its positive bivariate correlation with intention. This change in direction after simultaneous adjustment suggests that shared variance among correlated predictors may influence the regression coefficient and warrants cautious interpretation.
A multiple linear regression analysis was performed to examine the predictive effect of four variables—attitude toward safety practices, subjective norms toward identification, perceived behavioral control, and risk perception—on patients’ behavioral intention to notify staff when not wearing a hospital identification bracelet. The model was statistically significant, F(4, 460) = 619.186, p < 0.001, and explained 84.3% of the variance in behavioral intention (R2 = 0.843, Adjusted R2 = 0.842). The high explained variance should be interpreted cautiously because the predictors were strongly intercorrelated and all variables were obtained from the same self-report questionnaire.
Among the predictors, perceived behavioral control emerged as the strongest and most significant contributor (β = 0.563, p < 0.001), followed by risk perception (β = 0.252, p < 0.001) and attitude toward safety practices (β = 0.105, p < 0.001). However, subjective norms toward identification were not found to be a significant predictor of behavioral intention (β = 0.056, p = 0.266).
Overall, perceived behavioral control emerged as the strongest predictor of behavioral intention for both safety practices, whereas subjective norms were significant only for hand hygiene.
Discussion
The findings provide insight into factors associated with patients’ intentions to engage in safety-related behaviors in a hospital setting. Perceived behavioral control, attitude toward safety, and risk perception were associated with willingness to remind providers about hand hygiene or report missing identification bracelets. These associations are consistent with the TPB framework, but the cross-sectional design does not establish causal effects or actual patient engagement.
Participants reported stronger intentions for identification-related actions than for reminding providers about hand hygiene. Perceived behavioral control was the strongest predictor in both models, whereas subjective norms predicted hand-hygiene intention but not identification-related intention. This pattern suggests that perceived capability may be more consistently associated with intention than social approval across the two safety behaviors.
Additionally, patients perceived a higher level of risk associated with misidentification than with poor hand hygiene, which was reflected in stronger behavioral intentions toward identification-related practices. These findings highlight the central role of patients’ confidence and perceived capability in driving engagement in safety behaviors and suggest that interventions should prioritize enhancing perceived control and addressing patients’ risk perceptions.
The findings of this study support the theoretical assumptions of the Theory of Planned Behavior (TPB), highlighting the importance of psychosocial factors in shaping patients’ behavioral intentions toward safety practices. Perceived behavioral control (PBC) emerged as the most influential predictor of patients’ intention to act, both in reminding healthcare providers to perform hand hygiene and in reporting issues related to identification bracelets. Attitude toward safety and risk perception also played significant roles, although subjective norms demonstrated mixed effects across behaviors.
The strong impact of PBC is consistent with previous studies. Davis et al (2012) found that patients were more likely to act on safety concerns when they believed they had the capability to do so.6 Similarly, it was found that interventions designed to enhance patients’ sense of control and knowledge reduced adverse events and increased engagement.10 Furthermore, assertive patients were significantly more willing to speak up regarding hand hygiene, and familiarity with staff increased this willingness.14 In Uganda, Buregyeya et al (2024) emphasized the need for culturally sensitive empowerment strategies, as patients often perceive reminders as offensive or confrontational.11
Subjective norms were associated with hand-hygiene intention, consistent with Oliveira and Pinto (2018) and Stewardson et al (2013), who highlighted the role of staff–patient dynamics in patients’ willingness to speak up.15,16 In the Saudi hospital context, reminding a healthcare professional to clean their hands may be especially sensitive to interpersonal hierarchy, respect, and concern about being perceived as challenging the provider; therefore, visible staff endorsement and explicit invitations to speak up may strengthen normative support. By contrast, subjective norms were not a significant predictor of intention to report a missing identification bracelet. Identification checking may be viewed as a more procedural task with less dependence on interpersonal approval, which could reduce the influence of social norms. This interpretation should be considered exploratory because these cultural mechanisms were not directly measured. Previous studies also suggest that patients can play an active role in supporting healthcare providers’ hand hygiene practices, emphasizing the value of patient involvement in promoting safer care.17,18
Risk perception showed different adjusted associations across behaviors: positive for reporting identification problems but negative for reminding staff about hand hygiene. One possible explanation is that higher infection-risk awareness may coexist with greater concern about offending or confronting providers, which can suppress speaking-up intentions even when risk is recognized.14 Another possibility is statistical suppression arising from substantial overlap between risk perception and other TPB-related constructs. Because the study was cross-sectional and did not directly test these mechanisms, the negative coefficient should be interpreted cautiously rather than as evidence that greater risk perception reduces protective behavior.
In the context of identification, Davis et al (2012) confirmed the predictive power of risk perception and normative beliefs in motivating patient action.6 However, studies from South Africa and surgical settings indicated that low awareness about the importance of ID bracelets may weaken the influence of perceived risk.19,20 These findings suggest that while patients may conceptually understand the value of safety behaviors, action is more likely when supported by adequate knowledge and explicit institutional support.
The high correlations among some predictor variables and the unusually large R2 values (81.1% and 84.3%) raise the possibility of construct overlap and common-method variance because predictors and outcomes were measured in the same self-report questionnaire. These features can inflate shared variance and make individual regression coefficients less stable. The models should therefore be interpreted as strong explanatory associations within this sample rather than as evidence of causal or independent effects.
Overall, this study contributes to the growing body of evidence emphasizing the role of psychological and contextual factors in patient safety engagement. The results affirm the utility of TPB in this domain and highlight the need for healthcare systems to empower patients through education, supportive culture, and clear communication strategies. Future interventions should focus on strengthening patients’ confidence and ability to participate in safety-related behaviors while fostering a healthcare environment that encourages patient involvement.
Study Limitations
This study has several limitations. First, the cross-sectional design precludes causal inference. Second, convenience sampling from a single tertiary hospital may introduce selection bias and limits generalizability. Third, all measures were self-reported, creating potential social-desirability and common-method bias. Fourth, several predictors were highly correlated and the two models explained more than 80% of the variance, raising concern about multicollinearity and construct overlap. Finally, the study measured behavioral intention rather than observed behavior; intention may not translate into actual speaking-up or reporting actions. Future studies should use multisite probability or consecutive sampling where feasible, report multicollinearity and common-method diagnostics, incorporate objective behavioral outcomes, and use longitudinal or intervention designs to examine whether changes in TPB-related factors precede changes in patient behavior.
Conclusion
Patients’ behavioral intentions to remind providers about hand hygiene and report missing identification bracelets were associated with perceived behavioral control, attitudes, and risk perception, with perceived behavioral control showing the strongest association across both behaviors. These findings support the TPB as a useful framework for developing and testing context-sensitive patient-safety interventions. Educational materials, visual prompts, and staff invitations to speak up may be reasonable intervention components to evaluate, but the present cross-sectional data do not show that empowerment interventions improve actual patient behavior or safety outcomes.
Further research is needed to examine how cultural norms and healthcare dynamics influence patient empowerment across different regions. Additionally, studies exploring the transition from intention to actual behavior, particularly through intervention trials, would offer valuable insights into enhancing patient participation in safety practices.
Acknowledgments
The authors of this study extend their appreciation to the Ongoing Research Funding Program (ORF-2026-1135), King Saud University, Riyadh, Saudi Arabia.
Funding Statement
This work was supported by the Ongoing Research Funding Program (ORF-2026-1135), King Saud University, Riyadh, Saudi Arabia.
Data Sharing Statement
The datasets generated and/or analyzed during the current study are available from the corresponding author upon reasonable request.
Ethics Approval and Consent to Participate
This study was reviewed and approved by the Institutional Review Board of King Saud Medical City (Approval Number: H1R1-20-FEB-25-2). The study was conducted in accordance with the principles of the Declaration of Helsinki. Written informed consent was obtained from all participants prior to data collection. For participants younger than 18 years of age, written informed consent was obtained from a parent or legal guardian before participation.
Author Contributions
All authors made a significant contribution to the work reported, whether that is in the conception, study design, execution, acquisition of data, analysis and interpretation, or in all these areas; took part in drafting, revising or critically reviewing the article; gave final approval of the version to be published; have agreed on the journal to which the article has been submitted; and agree to be accountable for all aspects of the work.
Disclosure
The authors declare that they have no competing interests.
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Associated Data
This section collects any data citations, data availability statements, or supplementary materials included in this article.
Data Availability Statement
The datasets generated and/or analyzed during the current study are available from the corresponding author upon reasonable request.