Correction: Dual-Wavelength Photosensitive Nano-in-Micro Scaffold Regulates Innate and Adaptive Immune Responses for Osteogenesis

Correction to: Nano-Micro Letters (2021) 13:28 https://doi.org/10.1007/s40820-020-00540-z

Following publication of the original article [1], the authors identified several inadvertent errors in Figs. 1 and 3.

In Fig. 1c, due to an oversight during the final assembly of the figures, the authors mistakenly used a photograph from another group for the BCP-8W-CD146 panel. The original and correct photograph has now been provided. This error was purely layout-related; it does not affect the quantitative data, statistical analyses, or the scientific conclusions of the study.

In Fig. 3, three minor graphical errors occurred during the final typesetting and vector-formatting phase, which were unfortunately missed by the authors during proofreading. In Fig. 3i, the y-axis label for the β-TCP + DC2.4 group should read "1.5 K" instead of "1.5". In Fig. 3j, a minor column misalignment occurred in the BCP + 2.4 group. In Fig. 3l, the maximum value of the y-axis should be "20" instead of "25".

Fig. 3.

a Schematic diagram of biomaterial-mediated DC maturation and T cell activation. b FACS of all DCs (CD11c + , IA/IE +) and mature DCs (CD11c + , IA/IE + , CD86 +) recruitment at 2 weeks after biomaterials implantation in vivo. c Semiquantification of gating strategy cells in (B). n = 6, ****P < 0.0001. d IHC staining of CD11c—DC marker and CD83/CD40—mature DC markers at 4 weeks after biomaterials implantation in vivo. Red arrow, positive cell. Scale bar = 100 μm. M, material. e Semiquantification of positively stained cells in (d). n = 5, ****P < 0.0001. f Immunofluorescent (IF) staining of CD83 (red), CD40 (green) and nuclei (blue) after DCs seeded on the BCP or β-TCP for 24 h. Scale bar = 5 μm. g Semiquantification of positively stained cells in (f). n = 5, ****P < 0.0001, ns: not significant. h Relative mRNA expressions of DC maturation genes (MHC II, CD86, CD40, IL-12). n = 3, **P < 0.01, ***P < 0.001, ****P < 0.0001. i-l FACS of T cell proliferation (Ki67 +) and activation (IFN-γ) and semiquantification of positive cell rate. n = 6, ***P < 0.001, ****P < 0.0001, ns: not significant

The correct Figs. 1 and 3 have been provided in this Correction.

Fig. 1.

a Schematic diagram of BCP and β-TCP implantation and new bone formation. b Scheme, morphology and nanostructure of BCP and β-TCP observed by SEM. c Masson staining and IHC staining (CD146, Runx2 and Col1a1: MSC and osteoblast markers, red arrow) of implant area of BCP and β-TCP in vivo after 4 weeks (4 W) and 8 weeks (8 W) (the red dash line shows the new bone formation area; NB, new bone; M, material. Scale bar = 100 μm). d–f Semiquantification of new bone area and positively stained cells in (d). n = 5, ****P < 0.0001

The incorrect Fig. 1 is:

Fig. 1.

a Schematic diagram of BCP and β-TCP implantation and new bone formation. b Scheme, morphology and nanostructure of BCP and β-TCP observed by SEM. c Masson staining and IHC staining (CD146, Runx2 and Col1a1: MSC and osteoblast markers, red arrow) of implant area of BCP and β-TCP in vivo after 4 weeks (4 W) and 8 weeks (8 W) (the red dash line shows the new bone formation area; NB, new bone; M, material. Scale bar = 100 μm). d–f Semiquantification of new bone area and positively stained cells in (d). n = 5, ****P < 0.0001

The correct Fig. 1 is:

The incorrect Fig. 3 is:

Fig. 3.

a Schematic diagram of biomaterial-mediated DC maturation and T cell activation. b FACS of all DCs (CD11c + , IA/IE +) and mature DCs (CD11c + , IA/IE + , CD86 +) recruitment at 2 weeks after biomaterials implantation in vivo. c Semiquantification of gating strategy cells in (B). n = 6, ****P < 0.0001. d IHC staining of CD11c—DC marker and CD83/CD40—mature DC markers at 4 weeks after biomaterials implantation in vivo. Red arrow, positive cell. Scale bar = 100 μm. M, material. e Semiquantification of positively stained cells in (d). n = 5, ****P < 0.0001. f Immunofluorescent (IF) staining of CD83 (red), CD40 (green) and nuclei (blue) after DCs seeded on the BCP or β-TCP for 24 h. Scale bar = 5 μm. g Semiquantification of positively stained cells in (f). n = 5, ****P < 0.0001, ns: not significant. h Relative mRNA expressions of DC maturation genes (MHC II, CD86, CD40, IL-12). n = 3, **P < 0.01, ***P < 0.001, ****P < 0.0001. i-l FACS of T cell proliferation (Ki67 +) and activation (IFN-γ) and semiquantification of positive cell rate. n = 6, ***P < 0.001, ****P < 0.0001, ns: not significant

The correct Fig. 3 is:

The original article [1] has been corrected.