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Molecular Cancer logoLink to Molecular Cancer
. 2026 Oct 1;25:228. doi: 10.1186/s12943-026-02804-5

Retraction Note: Circular RNA circNRIP1 acts as a microRNA-149-5p sponge to promote gastric cancer progression via the AKT1/mTOR pathway

Xing Zhang 1,#, Sen Wang 1,#, Haixiao Wang 4,#, Jiacheng Cao 1,#, Xiaoxu Huang 1, Zheng Chen 2, Penghui Xu 1, Guangli Sun 1, Jianghao Xu 1, Jialun Lv 1, Zekuan Xu 1,3,✉
PMCID: PMC13629132  PMID: 42816886

Retraction Note: Mol Cancer 18, 20 (2019)

https://doi.org/10.1186/s12943-018-0935-5

The Editor-in-Chief has retracted this article. After publication, concerns were raised regarding similarities between the data presented in this article and the authors’ other publications [1, 2]. Specifically:

  • Fig. 5B miR-149-5p images appear highly similar to Fig. 6B si-cNRIP1;

  • Fig. 5E circNRIP1 ov day 1 image appears highly similar to Fig. 2F mir-133a-3p mimic day 10 in [1];

  • Fig. 5E si circNRIP1 day 10 image appears highly similar to Fig. 2E si-Control Day 10 in [2];

  • Fig. 6A PFK and P62 blots appear highly similar.

Additionally, the authors used SGC-7901, BGC-823 and MGC-803 cell lines, which have been reported to be contaminated with HeLa cervical cancer cells, in Figs. 1E, 2B-D and 3B-E.

The authors have explained that the image duplications occurred due to similar experimental design and errors in figure preparation across the three articles, and stated that the images presented in Fig. 5E are correct for this study. However, due to the high number of concerns, the Editor-in-Chief no longer has confidence in the presented data.

The authors have not responded to any correspondence from the publisher about this retraction notice.

Footnotes

Xing Zhang, Sen Wang, Haixiao Wang and Jiacheng Cao contributed equally to this work.

References

  • 1.Zhang X, Li Z, Xuan Z, Xu P, Wang W, Chen Z, Wang S, Sun G, Xu J, & Xu Z. Novel role of miR-133a-3p in repressing gastric cancer growth and metastasis via blocking autophagy-mediated glutaminolysis. J Exp Clin Cancer Res. 2018;37(1):320. 10.1186/s13046-018-0993-y. (Retraction published J Exp Clin Cancer Res. 2024 Jul 18;43(1):197. doi: https://doi.org/10.1186/s13046-024-03123-7). [DOI] [PMC free article] [PubMed] [Retracted]
  • 2.Yang J, Zhang X, Cao J, Xu P, Chen Z, Wang S, Li B, Zhang L, Xie L, Fang L, & Xu Z. Circular RNA UBE2Q2 promotes malignant progression of gastric cancer by regulating signal transducer and activator of transcription 3-mediated autophagy and glycolysis. Cell death & Dis. 2021;12(10):910. 10.1038/s41419-021-04216-3. [DOI] [PMC free article] [PubMed]

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