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. 1960 Feb;150(2):306–318. doi: 10.1113/jphysiol.1960.sp006389

The effects of γ-aminobutyrio acid and other compounds on structures of the mammalian nervous system which are inhibited by Factor I

A J Honour, H McLennan
PMCID: PMC1363166  PMID: 14402968

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Adrian E. D. The spread of activity in the cerebral cortex. J Physiol. 1936 Nov 6;88(2):127–161. doi: 10.1113/jphysiol.1936.sp003427. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. BASEMORE A. W., ELLIOT K. A., FLOREY E. Isolation of factor I. J Neurochem. 1957;1(4):334–339. doi: 10.1111/j.1471-4159.1957.tb12090.x. [DOI] [PubMed] [Google Scholar]
  3. BROWN G. L., PASCOE J. W. Conduction through the inferior mesenteric ganglion of the rabbit. J Physiol. 1952 Sep;118(1):113–123. doi: 10.1113/jphysiol.1952.sp004777. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. CURTIS D. R., PHILLIS J. W., WATKINS J. C. The depression of spinal neurones by gamma-amino-n-butyric acid and beta-alanine. J Physiol. 1959 Apr 23;146(1):185–203. doi: 10.1113/jphysiol.1959.sp006188. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. ELLIOTT K. A., FLOREY E. Factor I--inhibitory factor from brain; assay; conditions in brain; simulating and antagonizing substances. J Neurochem. 1956 Dec;1(2):181–192. doi: 10.1111/j.1471-4159.1956.tb12071.x. [DOI] [PubMed] [Google Scholar]
  6. ELLIOTT K. A., JASPER H. H. Gammaaminobutyric acid. Physiol Rev. 1959 Apr;39(2):383–406. doi: 10.1152/physrev.1959.39.2.383. [DOI] [PubMed] [Google Scholar]
  7. FLOREY E. An inhibitory and an excitatory factor of mammalian central nervous system, and their action of a single sensory neuron. Arch Int Physiol. 1954 Feb;62(1):33–53. doi: 10.3109/13813455409145367. [DOI] [PubMed] [Google Scholar]
  8. FLOREY E., MCLENNAN H. Effects of an inhibitory factor (factor I) from brain on central synaptic transmission. J Physiol. 1955 Nov 28;130(2):446–455. doi: 10.1113/jphysiol.1955.sp005418. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. FLOREY E., MCLENNAN H. The release of an inhibitory substance from mammalian brain, and its effect on peripheral synaptic transmission. J Physiol. 1955 Aug 29;129(2):384–392. doi: 10.1113/jphysiol.1955.sp005361. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. HAYASHI T. The inhibitory action of beta-hydroxy-gamma-aminobutyric acid upon the seizure following stimulation of the motor cortex of the dog. J Physiol. 1959 Mar 12;145(3):570–578. doi: 10.1113/jphysiol.1959.sp006163. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. IWAMA K., JASPER H. H. The action of gamma aminobutyric acid upon cortical electrical activity in the cat. J Physiol. 1957 Oct 30;138(3):365–380. doi: 10.1113/jphysiol.1957.sp005856. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. KUFFLER S. W., EDWARDS C. Mechanism of gamma aminobutyric acid (GABA) action and its relation to synaptic inhibition. J Neurophysiol. 1958 Nov;21(6):589–610. doi: 10.1152/jn.1958.21.6.589. [DOI] [PubMed] [Google Scholar]
  13. KURIAKI K., YAKUSHIJI T., NORO T., SHIMIZU T., SAJI S. gamma-Aminobutyrylcholine. Nature. 1958 May 10;181(4619):1336–1337. doi: 10.1038/1811336a0. [DOI] [PubMed] [Google Scholar]
  14. McLENNAN H. A comparison of some physiological properties of an inhibitory factor from brain (factor I) and of gamma-aminobutyric acid and related compounds. J Physiol. 1957 Nov 14;139(1):79–86. doi: 10.1113/jphysiol.1957.sp005876. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. McLENNAN H. Absence of gamma-aminobutyric acid from brain extracts containing factor I. Nature. 1958 Jun 28;181(4626):1807–1807. doi: 10.1038/1811807a0. [DOI] [PubMed] [Google Scholar]
  16. McLENNAN H. The identification of one active component from brain extracts containing factor I. J Physiol. 1959 May 19;146(2):358–368. doi: 10.1113/jphysiol.1959.sp006197. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. PURPURA D. P., GIRADO M., SMITH T. G., CALLAN D. A., GRUNDFEST H. Structure-activity determinants of pharmacological effects of amino acids and related compounds on central synapses. J Neurochem. 1959 Jan;3(3):238–268. doi: 10.1111/j.1471-4159.1959.tb12630.x. [DOI] [PubMed] [Google Scholar]
  18. TAKAHASHI H., NAGASHIMA A., KOSHINO C. Effect of gamma-aminobutyryl-choline upon the electrical activity of the cerebral cortex. Nature. 1958 Nov 22;182(4647):1443–1444. doi: 10.1038/1821443a0. [DOI] [PubMed] [Google Scholar]

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