ABSTRACT
Background and Aims
Alcohol consumption during pregnancy poses notable risks to maternal and foetal health, yet its prevalence and impact in Nigeria remain understudied. This narrative review aims to initiate conversations around the current state of alcohol intake by expectant mothers in Nigeria and Fetal Alcohol Spectrum Disorder (FASD), while providing recommendations to address this public health issue.
Methods
Drawing on existing literature, we highlight the prevalence of alcohol intake by expectant mothers in Nigeria and explore the socio‐cultural factors influencing drinking behaviors during pregnancy. Further to this, we initiate discussions around the impact of maternal alcohol intake with respect to FASD.
Results
Despite limited empirical evidence, available studies suggest that alcohol consumption during pregnancy is not uncommon in Nigeria, although reported prevalence estimates vary across studies and settings. Alcohol use during pregnancy may be influenced by factors such as social norms, lack of awareness, and limited access to prenatal care and education.
Conclusions
Key recommendations include implementing public health campaigns to raise awareness concerning the dangers of alcohol use by expectant mothers, integrating alcohol screening and counseling into routine prenatal care services, strengthening regulations on alcohol advertising and availability, and providing support services for women struggling with alcohol use disorders during pregnancy. By addressing the gaps in knowledge and practice surrounding alcohol consumption during pregnancy, Nigeria can take meaningful steps towards promoting maternal and child health and preventing the lifelong consequences of FASD and related conditions.
Keywords: alcohol drinking, fetal alcohol spectrum disorders, maternal health, pregnancy, prenatal alcohol exposure
1. Introduction
Alcohol consumption during pregnancy remains a major cause of adverse maternal and child health outcomes worldwide, including Fetal Alcohol Spectrum Disorders (FASD) [1]. Understanding global patterns of prenatal alcohol exposure provides essential context for interpreting the Nigerian situation. This article presents a narrative overview of selected evidence on alcohol use during pregnancy and FASD, and discusses practical public health strategies that may be implemented within existing healthcare and community systems in Nigeria. Given the dearth of research on this topic in Nigeria, the current article is positioned to initiate discussions in this area. The article is organized thematically and follows previous narrative reviews in this field [2, 3, 4].
2. Global Outlook on Alcohol Consumption During Pregnancy
Globally, assessing the rate of alcohol consumption by expectant mothers is challenging for several reasons. Some of the reasons include the absence of precise records documenting drinking habits during pregnancy, inaccuracies in self‐report data, and stigmatization [5, 6]. Nevertheless, studies have aimed to evaluate alcohol consumption in pregnancy, and a systematic review of these in 2017 found that nearly 10% of pregnant people used alcohol during pregnancy globally [7]. Although the studies reveal alcohol consumption patterns across different contexts, they primarily relied on self‐reported data and experimental designs susceptible to recall bias, selection bias, and attrition. Gilligan and colleagues suggest designing questionnaires with standardized beverage measurements to assess alcohol consumption rates, rather than relying on participants' self‐reported estimates [8]. However, methods that depend on participants' recall may be prone to selection bias. Although research has explored biomarkers such as hair analysis for detecting alcohol intake [9, 10], these are not routinely applied in clinical practice for prenatal alcohol exposure. Consequently, most studies rely on self‐reported alcohol use [11, 12, 13], which may underestimate true consumption.
Alcohol consumption during pregnancy has been associated with various sociodemographic factors, although findings are not always consistent across settings [11, 12, 13, 14]. Cannon and colleagues [11] reported higher rates among women who were older, unemployed, unmarried, from non‐Hispanic ethnic minority groups, and had lower educational attainment, findings that align with other studies [12, 13]. In contrast, a British cohort study found alcohol consumption during pregnancy to be more common among women with university‐level education and more affluent backgrounds [14]. These differences suggest that alcohol consumption during pregnancy is not confined to a single socioeconomic group and may be influenced by social, cultural, and contextual factors that vary across populations. Notably, these findings represent associations rather than causal relationships and highlight the need to avoid assumptions or stereotypes regarding alcohol use during pregnancy among particular demographic groups.
Rodriguez and his colleagues found a different social reaction in two Nordic countries that have contrasting societal policies regarding alcohol consumption by expectant mothers, particularly in the context of social adversity [15]. Finnish individuals tend to consume more significant amounts of alcohol when experiencing social adversity, even in light of Finland's conservative stance on alcohol. In contrast, Danish individuals, in comparable situations, consumed less alcohol despite Denmark's permissive stance on drinking. Additionally, research indicates that stressful life events are associated with alcohol consumption [16, 17]. These findings highlight the role of national policies and cultural norms in shaping alcohol consumption, emphasizing the need to consider local context when designing interventions in Nigeria. However, international guidance indicates that no level of alcohol consumption is considered safe during pregnancy, and complete abstinence is recommended to prevent prenatal alcohol exposure [18].
3. Alcohol Consumption During Pregnancy in Africa
Africa is an extensive continent with a population exceeding one billion individuals across 54 countries [19]. According to the latest Global Alcohol and Health Status Report [20], people aged ≥ 15 years in the WHO African Region (excluding Tunisia, Egypt, Morocco, Djibouti, Libya, Somalia, and Sudan, classified under the Eastern Mediterranean Region) consume 6.0 L of pure alcohol annually (4.2 L recorded; 1.8 L unrecorded), equivalent to 16.4 mL per day. This consumption corresponds to approximately 13 g/day of ethanol, roughly equivalent to one standard drink per day based on the commonly cited 10 g of ethanol per standard drink; however, definitions of a standard drink vary by country [21].
The World Health Organization (WHO) reports that women in Uganda, Burundi, Rwanda, Gabon, Namibia, and Nigeria are among the highest consumers of pure alcohol per capita (4.4–6.2 L annually) [20]. In contrast, some of the lowest levels of alcohol consumption are reported in Northern Africa, where long‐term abstinence rates exceed 88% [20]. Chad, Namibia, Uganda, and Ethiopia also report high female alcohol consumption (17.7–24.5 L per capita annually), among the highest globally [20].
A systematic review by Popova and colleagues estimated a pooled prevalence of alcohol consumption during pregnancy of 3.4% to 20.5% in Eastern Africa, 6.6% to 14.8% in Western Africa, 2.2% to 12.6% in Central Africa, ranging from 5.7% to 14.2% in Southern Africa, and 4.3% in Northern Africa [22]. Addila and colleagues, using a systematic review, reported a pooled prevalence estimate of alcohol use by expectant mothers in Sub‐Saharan Africa to be 20.8% [23].
Identified risk factors include poor social support and depression [24, 25]. Alcohol use is 1.6 times higher among expectant mothers with depression [23]. Alcohol use is twice as common in unplanned pregnancies [26, 27, 28]. According to these studies, alcohol use during pregnancy was encouraged by peers or friends who also drank. Pregnant individuals who knew that alcohol consumption negatively affects birth outcomes, however, were 64% less likely to drink during their pregnancy than their peers [23].
Despite the WHO global strategy to reduce harmful alcohol use, adopted at the 63rd World Health Assembly and emphasizing prevention among pregnant women and women of reproductive age [29], research across African countries remains limited. Existing studies rely largely on self‐reported data, lack biomarker validation, and inconsistently use validated tools. Consequently, there is a possibility of underreporting, recall bias, or social desirability responses. Additionally, most systematic reviews included only English‐language studies, potentially excluding French publications and introducing reporting bias.
4. Alcohol Consumption During Pregnancy in Nigeria: Patterns, Predictors, and Socio‐Cultural Factors
Alcohol consumption during pregnancy is significant in Nigeria, posing potential risks to both parents and unborn children [30]. Ordinioha and Brisibe employed a descriptive cross‐sectional design with an interviewer‐administered questionnaire to evaluate alcohol consumption among 221 pregnant women at the University of Port Harcourt Teaching Hospital in Nigeria. The study assessed the knowledge of women's attitude towards alcohol use and actual alcohol consumption and found that 59.3% consumed alcohol during the index pregnancy [30]. Onwuka and his colleagues, using a cross‐sectional design, determined the rate of alcohol consumption to be 22.6% among 380 pregnant women at the University of Nigeria Teaching Hospital in Nigeria [31]. Martinez and colleagues, using World Health Survey data from adult women across African countries, reported heavy drinking among 38% of current female drinkers in Nigeria [32]. Ordinioha and Brisibe reported high levels of alcohol consumption during pregnancy, with 37.4% of those who consumed alcohol classified as regular drinkers and 25.8% of the total study sample meeting the study definition of binge drinking [30]. Adeoye reported a prevalence of alcohol consumption during pregnancy of 12.7% in the Ibadan Pregnancy Cohort Study [33]. Popova and his colleagues' meta‐analysis combined the results of seven studies to arrive at an overall prevalence of consumption of alcohol during pregnancy of 8.1% (2.5%─15.4%) for Nigeria [22].
Definitions and measurement of alcohol exposure varied across the studies reviewed. Ordinioha and Brisibe defined alcohol consumption as intake of any alcoholic beverage during the index pregnancy, including alcohol consumed as part of native herbal preparations, and defined binge drinking as four or more standard units on a single occasion; one standard drink contained approximately 13 g of ethanol [30]. Onwuka et al. similarly defined alcohol consumption as intake of any alcoholic beverage during the index pregnancy and used approximately 13 g of ethanol per standard drink, but defined binge drinking as four or more standard units on a single occasion within 2 h [31]. Adeoye assessed current alcohol consumption by self‐report and beverage consumption during the preceding 6 weeks; however, the study did not quantitatively measure alcohol consumption and therefore could not assess binge drinking [33]. In contrast, Martinez et al., whose sample comprised adult women rather than specifically pregnant women, defined current drinking as at least one standard drink in the previous 7 days, heavy drinking as 15 or more standard drinks during the previous 7 days, and risky single‐occasion drinking as five or more standard drinks on at least 1 day during that period; standard drinks contained 8–13 g of ethanol depending on the country [32]. These differences in exposure definitions, standard‐drink quantities, recall periods, study populations, and measurement approaches limit direct comparison of prevalence estimates across studies.
Reported prevalence of alcohol consumption during pregnancy varies across Nigerian settings, with lower rates reported in some northern settings and higher rates in some southern settings [30, 33]. These regional differences may reflect interacting cultural, religious, social, economic, healthcare‐related, and environmental influences rather than any single population characteristic. Methodological differences between studies, including differences in study populations, sampling approaches, and measurement of alcohol consumption, may also contribute to apparent regional variation. The available evidence should therefore be interpreted as reflecting contextual associations rather than inherent differences between religious or demographic groups. Alcohol use during pregnancy in Nigeria is best understood within a biopsychosocial and structural framework in which individual behaviors interact with interpersonal, community, economic, healthcare, cultural, and policy environments [30]. Alcohol regulation and availability vary across Nigerian regions, reflecting differences in local laws, cultural and religious norms, and the social acceptability of alcohol, with some jurisdictions imposing restrictions or prohibitions on alcohol sales [33]. Alcohol is also available through informal outlets, including local drinking establishments and market stalls, where alcoholic beverages may be sold at relatively low prices [30]. Alcohol may also be provided free of charge at social and community events, while widespread alcohol advertising may contribute to environments in which drinking is socially normalized [30]. These factors illustrate how regulatory, commercial, cultural, and community environments may interact with individual circumstances to shape alcohol consumption during pregnancy. Emotional states experienced by pregnant women, ranging from excitement to anxiety, have been associated with drinking behaviors [34]. Psychological factors, including intimate partner violence, may also contribute to alcohol use during pregnancy in Nigeria [35, 36, 37]. Marital distress and lower levels of marital satisfaction have also been associated with alcohol use [33, 34, 38].
Sociodemographic factors such as age, educational attainment, marital status, and household income have been associated with alcohol consumption during pregnancy in Nigeria [33]. In Nigeria, individuals between 26 and 34 years old show the highest prevalence of alcohol consumption during pregnancy, while binge drinking is more common among those aged 18 to 25 [39]. Younger individuals, particularly teenagers, tend to be more involved in prenatal alcohol use, potentially due to unplanned pregnancies and associated stressors [40]. Prepregnancy alcohol use emerges as a significant predictor of alcohol consumption during pregnancy, highlighting the significance of early intervention and support for individuals with a record of alcohol use [33]. According to Onwuka and colleagues, individuals with less than a tertiary education were significantly more prone to consume alcohol while pregnant. They suggested that limited knowledge or inadequate education might contribute to this behavior, as those with lower education levels may be less knowledgeable about the dangers of consuming alcohol while pregnant. Specifically, 31.1% of individuals with below secondary education reportedly consume alcohol during pregnancy, compared with 19.3% of those with tertiary education [31]. These associations may also reflect broader barriers, including differences in health literacy and access to healthcare services. Similarly, Adeoye reported that the prevalence of alcohol consumption during pregnancy was 16.33% among individuals with primary education, 12.9% among those with secondary education, and 12.46% among those with tertiary education [33]. Taken together, the available evidence suggests that alcohol consumption during pregnancy in Nigeria cannot be adequately explained by a single cultural, religious, or demographic characteristic. Rather, drinking behaviors appear to occur within interacting individual, interpersonal, social, healthcare, economic, cultural, and regulatory contexts. Prepregnancy alcohol use, psychological and relationship circumstances, socioeconomic conditions, health literacy, access to healthcare and information, alcohol availability and affordability, regulatory environments, and prevailing social and cultural norms may collectively shape alcohol use during pregnancy.
5. Effects of Alcohol Consumption on Pregnancy
Alcohol, recognized as a teratogen, can adversely affect foetal development when consumed during pregnancy [1, 41, 42]. It may result in a range of developmental, physical, and health‐related challenges [43, 44, 45, 46]. The severity and complexity of these effects depend upon the dosage, frequency, and timing of alcohol exposure [47, 48, 49]. For instance, alcohol exposure can affect the brain at any stage of pregnancy. However, significant structural changes, such as structural brain changes and characteristic facial differences, are more likely during the first trimester compared with developmental changes later [50, 51, 52], although such physical features are relatively uncommon in clinical practice.
In addition to the quantity and timing of alcohol exposure, there is a wide range of factors that may influence developmental outcomes, such as maternal nutrition [45, 53], smoking [54], and genetic predisposition of the mother and foetus [55]. Furthermore, it is often difficult to distinguish the effects of prenatal alcohol exposure from those associated with adverse childhood experiences, genetics, trauma, family history, and other environmental influences, which may interact to influence developmental outcomes. Therefore, developmental outcomes following prenatal alcohol exposure should be understood as multifactorial and heterogeneous, reflecting the potential interaction of prenatal alcohol exposure with biological, maternal, genetic, social, and environmental factors. Consequently, developmental difficulties among alcohol‐exposed children should not automatically be attributed solely to prenatal alcohol exposure. This finding suggests that the exact levels of alcohol necessary to cause harm are unknown and vary from individual to individual. Because of this variability in susceptibility to risk, epidemiological studies sometimes do not detect harm at low/moderate levels of alcohol consumption. Systematic reviews investigating the outcome of low to mid‐level alcohol use during pregnancy have found that the evidence to confirm either harm or benefit at this level is inconclusive, although some studies included in the reviews reported birth complications [56, 57, 58] and identified specific fatty acid concentrations (essential for foetal neural development) in individuals who consumed alcohol during pregnancy compared with control groups, enhancing the understanding of alcohol's effects on neural development in those whose intake varied from ‘moderate to heavy' amounts. Due to the potentially severe consequences of prenatal alcohol exposure and the unknown risk for each individual, current expert advice is abstinence from alcohol during pregnancy. However, outcomes may be improved by protective factors such as stable caregiving environments, early identification, and access to appropriate support services.
6. Overview of FASD
FASD encompasses various disorders resulting from prenatal alcohol exposure [59]. The spectrum includes four closely related conditions: Alcohol‐related neurodevelopmental disorder (ARND), fetal alcohol syndrome (FAS), Alcohol‐Related Birth Defects (ARBD), and Partial Fetal Alcohol Syndrome (PFAS) [60]. FAS is the most commonly identifiable form in the spectrum [61], although the four conditions described exhibit different degrees of associated impairments. The sentinel facial features associated with FAS are relatively uncommon and are influenced by the timing, frequency, and level of prenatal alcohol exposure. Globally, a systematic review and meta‐analysis estimate that FASD affects more than 7 out of every 1000 births [62]. Over half of the countries analyzed in the study showed an elevated FASD prevalence exceeding 1%, with South Africa reporting the highest (exceeding 100 cases per 1000 births), as corroborated by the meta‐analysis conducted by Roozen and colleagues [63]. In the UK, Lange and colleagues reported an FASD rate of 3.24% through a meta‐analysis [62], while McQuire and colleagues, employing a screening algorithm within a UK birth cohort, identified FASD prevalence of 17% for singly imputed data and 7.2% in complete‐case analysis [64]. Based on an annual cohort of close to 4 million live births in the United States, we can anticipate approximately 144,000 newly diagnosed FASD cases annually, averaging approximately 394 cases per day, based on a midpoint prevalence rate of 3.6% [65]. A recent case ascertainment study using a cross‐sectional design among 6639 children in the United States reported a prevalence rate of 1.1% to 5.0% [66]. An increasing body of evidence from different settings highlights the substantial economic consequences of FASD. For example, a systematic review estimates that the annual expenses associated with caring for individuals diagnosed with FASD in Canada range between CAD$300 million and CAD$6 billion, and in the United States, between USD$150 million and USD$9 billion [67]. In the United Kingdom, FASD also exerts a significant economic burden, as parents of children with FASD are unable to work and claim additional benefits [68]. Moreover, it is estimated that educating these children in care will cost GDP£100 million, with support expenses exceeding GDP£3000 per week [68]. These estimates encompass medical, diagnostic, social services, and correctional costs. Nonetheless, these expenses are underestimated due to the prevalence of undiagnosed or misdiagnosed FASD cases, along with a range of unconsidered factors that contribute to overall FASD‐related costs [69]. The financial strain that FASD places on society may be alleviated by recognizing the specific needs of individuals affected by FASD and by implementing timely interventions and appropriate social policies [70, 71].
7. Prevalence of FASD in Africa and Nigeria
The prevalence of FASD in Africa, including in Nigeria, remains understudied, with limited literature available. South Africa stands as an exception, with most research publications on FASD originating from this region. There is a significant knowledge gap regarding the prevalence of this condition across the continent, despite evidence of substantial alcohol use among expectant mothers in Africa [7]. In South Africa, May and colleagues reported an FASD prevalence of approximately 310 per 1000 using population‐based, active case ascertainment among a school‐based cohort that included 213 controls: 2 with FAS, 64 with PFAS, 77 with ARND, and 95 with ARBD [72]. The prevalence of FASD in South Africa is as high as 290 per 1000 (or 29%) in the Winelands area, as reported by Olivier and colleagues, who employed active case ascertainment methods, including anthropometric screening, clinical evaluations, neurodevelopmental assessments of first‐graders, dysmorphology exams, and interviews to estimate alcohol consumption during pregnancy [73]. Epidemiological studies conducted in high‐risk communities in the Western Cape Province documented FASD rates of 17%–23%, with FAS rates among school‐age children ranging from 5.9% to 7.9% [74]. Moreover, a review of studies assessing grade 1 school learners in various South African towns reported FASD rates ranging from 2.9% to 29% [74].
Despite evidence of alcohol consumption during pregnancy in Nigeria, the prevalence and population‐level burden of FASD in the country remain uncertain because direct epidemiological evidence is limited. Modeling based on estimates of alcohol consumption has produced an estimated prevalence of FAS of 14.8 (95% CI: 8.9–21.5) per 10,000 in Africa [7]. However, this modeled African estimate should not be interpreted as a direct estimate of FAS or FASD prevalence in Nigeria. Similarly, prevalence estimates from South Africa provide important regional context but cannot be directly extrapolated to Nigeria because of differences in alcohol exposure patterns, population characteristics, socioeconomic and cultural contexts, healthcare access, diagnostic capacity, and study methods. Therefore, the available evidence indicates a need for further investigation but is insufficient to determine the prevalence or population‐level burden of FASD in Nigeria. Population‐based Nigerian studies using standardized measures of prenatal alcohol exposure and validated approaches to FASD ascertainment are needed to establish prevalence and examine geographical variation.
8. Impact of Lack of Knowledge About Alcohol Consumption During Pregnancy on the Health Sector in Nigeria
Despite the well‐documented dangers of prenatal alcohol exposure, there remains a lack of awareness among the Nigerian population, particularly among pregnant women and women of reproductive age. For example, a study by Ordinioha and Brisibe found that only 51.58% of respondents were aware of the harmful effects of alcohol on the foetus. Among those who were informed, the majority (62.29%) cited health professionals as their source of information, while others relied on the internet (18.42%), mass media (7.89%), or friends and spouses (11.40%) [30]. Similarly, Onwuka and colleagues reported that 35.5% of respondents recognized the risks of alcohol consumption during pregnancy, whereas 64.5% were unaware. Sources of awareness in this group included print media (33.3%), health professionals (30.4%), electronic media such as the internet (28.9%), and friends or colleagues (6.7%) [31]. Limited awareness of the risks associated with alcohol consumption during pregnancy may have implications for prevention, early intervention, and maternal and child health services in Nigeria. It poses significant risks to maternal and foetal health, leading to adverse birth outcomes and long‐term developmental impairments [75]. These consequences may result in increased demand for healthcare services related to pregnancy complications and developmental disorders, placing additional pressure on healthcare and necessitating increased resources for prenatal care, neonatal intensive care, and long‐term interventions for affected individuals [76, 77]. The lack of awareness among healthcare providers regarding the hazards linked to alcohol consumption during pregnancy results in missed chances for timely intervention and prevention [78]. Insufficient knowledge and training among healthcare professionals may lead to inadequate screening of alcohol use by expectant mothers or the provision of suitable counseling and support. These deficiencies perpetuate a cycle of negative maternal and foetal consequences, exacerbating the strain on Nigeria's already burdened healthcare system [78].
Moreover, there is a transgenerational effect of prenatal alcohol exposure, with each episode of drinking during pregnancy exposing multiple generations to its hazardous effects [79]. Prenatal alcohol exposure has been correlated with elevated mortality rates among individuals diagnosed with FASD and their siblings, presenting a considerable burden on the healthcare system [80, 81]. Individuals affected by FASD frequently need medical care for physical impairments and mental disorders, along with rehabilitation services, specialized education, and social support [78]. Furthermore, studies highlight the increased risks associated with prenatal alcohol exposure, such as cognitive and behavioral deficits, sudden infant death syndrome, neonatal death, prenatal and postnatal growth deficiencies, spontaneous abortion, stillbirth, as well as preterm delivery [82, 83, 84]. All these impacts may be detrimental to the Nigerian health sector.
9. Conclusion and Recommendations
Available studies indicate that alcohol consumption during pregnancy occurs in Nigeria, with some studies reporting relatively high levels in particular settings, including 59.3% reporting alcohol consumption during the index pregnancy and 25.8% meeting the study definition of binge drinking in one southern Nigerian study [30]. However, reported prevalence of prenatal alcohol exposure varies across studies and settings, and evidence of prenatal alcohol exposure should not be interpreted as equivalent to evidence of FASD prevalence. Although studies from other countries and modeled estimates provide important context, direct epidemiological evidence from Nigeria remains limited, and the available evidence is insufficient to reliably estimate the national prevalence or population‐level burden of FASD. Therefore, robust population‐based Nigerian studies using standardized exposure measures and validated FASD ascertainment methods are needed to establish the prevalence and population‐level burden of FASD in Nigeria.
Key recommendations for addressing alcohol consumption during pregnancy in Nigeria encompass a multifaceted approach aimed at raising awareness, enhancing healthcare services, and strengthening regulatory measures. One critical recommendation is the implementation of public health campaigns designed to increase awareness about the risks associated with alcohol intake during pregnancy. These campaigns should be strategically designed to reach women of childbearing age, their families, healthcare providers, and the broader community. By leveraging various communication channels such as community outreach programmes, social media, television, and radio, these campaigns can disseminate accurate information about the consequences of prenatal alcohol exposure and promote the adoption of healthier behaviors. Additionally, ensuring universal access to reliable contraception, particularly hormonal methods, is crucial and aligns with global strategies aimed at reducing unintended pregnancies and preventing prenatal alcohol exposure. This universal access to reliable contraception is especially important because a significant proportion of pregnancies are unplanned. Hormonal contraceptives offer a more consistent means of preventing unintended pregnancies compared with methods depending on behavioral changes, such as condoms or abstinence, thus reducing the risk of FASD.
Furthermore, the incorporation of alcohol screening and counseling into routine prenatal care services is vital for early detection and intervention. Healthcare professionals are pivotal in recognizing women who might be susceptible to alcohol consumption during pregnancy and delivering suitable assistance and counseling. By incorporating standardized screening tools and counseling protocols into prenatal care visits, healthcare professionals can effectively assess alcohol consumption patterns, educate pregnant women about the risks, and offer interventions to reduce or abstain from alcohol use during pregnancy.
In addition to healthcare interventions, strengthening regulations on alcohol advertising and availability is paramount in curbing the prevalence of alcohol intake by expectant mothers. Nigeria should enact and enforce strict regulations to restrict the marketing, promotion, and sale of alcoholic beverages, particularly targeting pregnant women and young adults of childbearing age. This approach may involve implementing restrictions on alcohol advertising in media channels frequented by pregnant women, such as health‐related magazines, prenatal clinics, and maternal health websites.
Women who are pregnant and who are known to be struggling with alcohol addiction should be given targeted specialist support to reduce alcohol consumption. Support services should be made available. These may include counseling, substance abuse treatment programmes, and peer support groups tailored to the unique needs of pregnant women. By offering accessible and culturally sensitive support services, Nigeria can empower women to seek help, address their alcohol use disorders, and make healthier choices for themselves and their babies.
In conclusion, addressing the gaps in knowledge and practice surrounding alcohol consumption during pregnancy in Nigeria requires a comprehensive and coordinated effort from various stakeholders, including healthcare providers, civil society, community organizations, and government agencies. However, the current capacity of the health system to provide multidisciplinary FASD assessments may be limited, particularly in resource‐constrained settings, which could restrict formal diagnosis rates. Strengthening clinician training may represent more feasible initial steps. Furthermore, we recommend conducting prevalence studies that include surveys of pregnant women and, where feasible, biomarker testing such as hair or meconium analysis. While biomarker approaches are not routinely implemented in most international health systems and may pose logistical and cost challenges, they may offer additional research value in selected settings. These efforts may strengthen understanding of prenatal alcohol exposure patterns and, when combined with validated approaches to FASD ascertainment, contribute to more reliable estimates of FASD prevalence and population‐level burden. However, support for children with developmental needs should be guided by individual strengths and needs and should not depend solely on confirmation of prenatal alcohol exposure or a formal FASD diagnosis. By implementing the key recommendations outlined above, Nigeria can take meaningful steps to promote maternal and child health, prevent the lifelong consequences of FASD, and ensure a healthier future for its population.
Author Contributions
Stephen I. Azumara: conceptualization, writing – original draft, writing – review and editing, resources. Elijah C. Arodiogbu: conceptualization, resources, writing – review and editing, writing – original draft. Penny A. Cook: conceptualization, writing – original draft, writing – review and editing, resources. Raja A. S. Mukherjee: conceptualization, writing – original draft, writing – review and editing, resources. David J. Gilbert: conceptualization, writing – original draft, writing – review and editing, resources.
Funding
The authors have nothing to report.
Ethics Statement
Ethical approval was not required for this study as it is a narrative review. No study participants were involved, and the review solely relies on publicly available literature without direct interaction or data collection from individuals.
Conflicts of Interest
The authors declare no conflicts of interest.
Transparency Statement
Stephen I. Azumara affirms that this manuscript is an honest, accurate, and transparent account of the study being reported; that no important aspects of the study have been omitted.
Acknowledgments
The authors declare that there are no external contributions or support to acknowledge for this review article.
Contributor Information
Stephen I. Azumara, Email: stephenazumara@gmail.com.
David J. Gilbert, Email: d.j.gilbert1@salford.ac.uk.
Data Availability Statement
This research did not generate or analyze new data; the concept of data sharing does not apply to this article.
References
- 1. Chung D. D., Pinson M. R., Bhenderu L. S., Lai M. S., Patel R. A., and Miranda R. C., “Toxic and Teratogenic Effects of Prenatal Alcohol Exposure on Fetal Development, Adolescence, and Adulthood,” International Journal of Molecular Sciences 22 (2021): 8785. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 2. Suttie M., Kable J., Mahnke A. H., and Bandoli G., “Machine Learning Approaches to the Identification of Children Affected by Prenatal Alcohol Exposure: A Narrative Review,” Alcohol, Clinical and Experimental Research 48 (2024): 585–595. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 3. Yousefi N. and Chaufan C., “Think Before You Drink': Challenging Narratives on Foetal Alcohol Spectrum Disorder and Indigeneity in Canada,” Health: An Interdisciplinary Journal for the Social Study of Health, Illness and Medicine 26 (2022): 622–642. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 4. Stewart M., “Fictions of Prevention: Fetal Alcohol Spectrum Disorder and Narratives of Responsibility,” North American Dialogue 19 (2016): 55–66. [Google Scholar]
- 5. Binder A., Preiser C., Hanke S., et al., “Researching Alcohol Consumption During Pregnancy. Opportunities and Challenges With Two Methods of Data Acquisition,” Qualitative Health Research 32 (2022): 1809–1827. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 6. Williams P. P., Mathews C., Jordaan E., Washio Y., Terplan M., and Parry C. D., “Validation of Simple Dichotomous Self‐Report on Prenatal Alcohol and Other Drug Use in Women Attending Midwife Obstetric Units in the Cape Metropole, South Africa,” Clinical Ethics 15 (2020): 181–186. [Google Scholar]
- 7. Popova S., Lange S., Probst C., Gmel G., and Rehm J., “Estimation of National, Regional, and Global Prevalence of Alcohol Use During Pregnancy and Fetal Alcohol Syndrome: A Systematic Review and Meta‐Analysis,” Lancet Global Health 5 (2017): e290–e299. [DOI] [PubMed] [Google Scholar]
- 8. Gilligan C., Anderson K. G., Ladd B. O., Yong Y. M., and David M., “Inaccuracies in Survey Reporting of Alcohol Consumption,” BMC Public Health 19 (2019): 1639. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 9. Pragst F. and Balikova M. A., “State of the Art in Hair Analysis for Detection of Drug and Alcohol Abuse,” Clinica Chimica Acta 370 (2006): 17–49. [DOI] [PubMed] [Google Scholar]
- 10. Cappelle D., Lai F. Y., Covaci A., et al., “Assessment of Ethyl Sulphate in Hair as a Marker for Alcohol Consumption Using Liquid Chromatography–Tandem Mass Spectrometry,” Drug Testing and Analysis 10 (2018): 1566–1572. [DOI] [PubMed] [Google Scholar]
- 11. Cannon M. J., Dominique Y., O'Leary L. A., Sniezek J. E., and Floyd R. L., “Characteristics and Behaviors of Mothers Who Have a Child With Fetal Alcohol Syndrome,” Neurotoxicology and Teratology 34 (2012): 90–95. [DOI] [PubMed] [Google Scholar]
- 12. McDonald S. W., Hicks M., Rasmussen C., Nagulesapillai T., Cook J., and Tough S. C., “Characteristics of Women Who Consume Alcohol Before and After Pregnancy Recognition in a Canadian Sample: A Prospective Cohort Study,” Alcoholism: Clinical and Experimental Research 38 (2014): 3008–3016. [DOI] [PubMed] [Google Scholar]
- 13. Roberts S. C. M., Mericle A. A., Subbaraman M. S., et al., “State Policies Targeting Alcohol Use During Pregnancy and Alcohol Use Among Pregnant Women 1985–2016: Evidence From the Behavioral Risk Factor Surveillance System,” Women's Health Issues 29 (2019): 213–221. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 14. Nykjaer C., Alwan N. A., Greenwood D. C., et al., “Maternal Alcohol Intake Prior to and During Pregnancy and Risk of Adverse Birth Outcomes: Evidence From a British Cohort,” Journal of Epidemiology and Community Health 68 (2014): 542–549. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 15. Rodriguez A., Olsen J., Kotimaa A. J., et al., “Is Prenatal Alcohol Exposure Related to Inattention and Hyperactivity Symptoms in Children? Disentangling the Effects of Social Adversity,” Journal of Child Psychology and Psychiatry 50 (2009): 1073–1083. [DOI] [PubMed] [Google Scholar]
- 16. Beijers C., Ormel J., Meijer J. L., Verbeek T., Bockting C. L. H., and Burger H., “Stressful Events and Continued Smoking and Continued Alcohol Consumption During Mid‐Pregnancy,” PLoS One 9 (2014): e86359. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 17. Esper L. H. and Furtado E. F., “Stressful Life Events and Alcohol Consumption in Pregnant Women: A Cross‐Sectional Survey,” Midwifery 71 (2019): 27–32. [DOI] [PubMed] [Google Scholar]
- 18. World Health Organization , “WHO Public Hearing on Harmful Use of Alcohol (Vol. IV): Alcohol Industry, Trade and Agriculture,” accessed February 2, 2026, https://cdn.who.int/media/docs/default-source/alcohol/public-hearing-on-harmful-use-of-alcohol/volume-iv-alcohol-industry-trade-and-agriculture.pdf?sfvrsn=eca37a0f_2.
- 19. World Bank Group Africa , “Africa Overview: Development News, Research, Data,” 2023, https://www.worldbank.org/en/region/afr.
- 20. World Health Organization , Global Information System on Alcohol and Health (GISAH) (WHO, 2014), http://apps.who.int/gho/data/?showonly=GISAH&theme=main.
- 21. World Health Organization , Global Status Report on Alcohol and Health 2018 (World Health Organization, 2018), https://iris.who.int/handle/10665/274603.
- 22. Popova S., Lange S., Probst C., et al., “Actual and Predicted Prevalence of Alcohol Consumption During Pregnancy in the Who African Region,” Tropical Medicine & International Health 21 (2016): 1209–1239. [DOI] [PubMed] [Google Scholar]
- 23. Addila A. E., Bisetegn T. A., Gete Y. K., et al., “Alcohol Consumption and Its Associated Factors Among Pregnant Women in Sub‐Saharan Africa: A Systematic Review and Meta‐Analysis,” Substance Abuse Treatment, Prevention, and Policy 15 (2020): 29. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 24. Wubetu A. D., Habte S., and Dagne K., “Prevalence of Risky Alcohol Use Behavior and Associated Factors in Pregnant Antenatal Care Attendees in Debre Berhan, Ethiopia, 2018,” BMC Psychiatry 19 (2019): 250. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 25. Takelle G. M., Nakie G., Rtbey G., and Melkam M., “Depressive Symptoms and Associated Factors Among Pregnant Women Attending Antenatal Care at Comprehensive Specialized Hospitals in Northwest Ethiopia, 2022: An Institution‐Based Cross‐Sectional Study,” Frontiers in Psychiatry 14 (2023): 1148638. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 26. Anteab K., Demtsu B., and Megra M., “Assessment of Prevalence and Associated Factors of Alcohol Use During Pregnancy Among the Dwellers of Bahir‐Dar City, Northwest Ethiopia,” International Journal of Pharmacy and Pharmaceutical Sciences 5 (2014): 939–946. [Google Scholar]
- 27. Mekuriaw B., Belayneh Z., Shemelise T., and Hussen R., “Alcohol Use and Associated Factors Among Women Attending Antenatal Care in Southern Ethiopia: A Facility Based Cross Sectional Study,” BMC Research Notes 12 (2019): 690. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 28. Mpelo M., Kibusi S. M., Moshi F., Nyundo A., Ntwenya J. E., and Mpondo B. C. T., “Prevalence and Factors Influencing Alcohol Use in Pregnancy Among Women Attending Antenatal Care in Dodoma Region, Tanzania: A Cross‐Sectional Study,” Journal of Pregnancy 2018 (2018): 8580318. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 29. Chick J., “The WHO Global Strategy to Reduce the Harmful Use of Alcohol,” Alcohol and Alcoholism 46 (2011): 223. [DOI] [PubMed] [Google Scholar]
- 30. Ordinioha B. and Brisibe S., “Alcohol Consumption Among Pregnant Women Attending the Ante‐Natal Clinic of a Tertiary Hospital in South‐South Nigeria,” Nigerian Journal of Clinical Practice 18 (2015): 13–17. [DOI] [PubMed] [Google Scholar]
- 31. Onwuka C. I., Ugwu E. O., Dim C. C., et al., “Prevalence and Predictors of Alcohol Consumption During Pregnancy in South‐Eastern Nigeria,” Journal of Clinical and Diagnostic Research 10 (2016): QC10. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 32. Martinez P., Røislien J., Naidoo N., and Clausen T., “Alcohol Abstinence and Drinking Among African Women: Data From the World Health Surveys,” BMC Public Health 11 (2011): 160. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 33. Adeoye I. A., “Alcohol Consumption and Tobacco Exposure Among Pregnant Women in Ibadan, Nigeria,” BMC Psychiatry 22 (2022): 570. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 34. Effiong J. E., Umoh O. O., Ogunleye A. J., Effiong J. E., and O Umoh O., “Marital Satisfaction, Age and Alcohol Use During Pregnancy: An Empirical Study Of Pregnant Women in Uyo Metropolis, Nigeria,” European Scientific Journal 12 (2016): 241. [Google Scholar]
- 35. Nelson E.‐U., “Alcohol Use, Intimate Partner Violence and Family Well Being: A Qualitative Study in Oron, Nigeria,” African Journal of Drug and Alcohol Studies 14 (2015): 105–113. [Google Scholar]
- 36. Oladeji B. D., Bello T., Ayinde O., Idowu P., and Gureje O., “Prevalence and Correlates of Depression Among Pregnant Adolescents in Primary Maternal Care in Nigeria,” Archives of Women's Mental Health 25 (2022): 441–450. [DOI] [PubMed] [Google Scholar]
- 37. Soyemi A. O., Sowunmi O. A., Amosu S. M., and Babalola E. O., “Depression and Quality of Life Among Pregnant Women in First and Third Trimesters in Abeokuta: A Comparative Study,” South African Journal of Psychiatry 28 (2022): 1779. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 38. Ifeoma Odinka J., Nwoke M., Chukwuorji J. C., et al., “Dependent Personality, Mindful Awareness, and Marital Satisfaction and Their Association With Postpartum Psychological Distress in Two Tertiary Hospitals, Southeast Nigeria,” Journal of Health Care for the Poor and Underserved 31 (2020): 920–938. [DOI] [PubMed] [Google Scholar]
- 39. Centers for Disease Control and Prevention , “Alcohol Use Among Pregnant and Nonpregnant Women of Childbearing Age‐United States, 1991–2005,” MMWR. Morbidity and Mortality Weekly Report 58 (2009): 529–532. [PubMed] [Google Scholar]
- 40. Meschke L. L., Holl J., and Messelt S., “Older Not Wiser: Risk of Prenatal Alcohol Use by Maternal Age,” Maternal and Child Health Journal 17 (2012): 147–155. [DOI] [PubMed] [Google Scholar]
- 41. Aiton N., “How Does Alcohol Affect the Developing Fetus?” in Prevention, Recognition and Management of Fetal Alcohol Spectrum Disorders, ed. Mukherjee R. A. S. and Aiton N. (Springer, 2021), 35–53. [Google Scholar]
- 42. DeJong K., Olyaei A., and Lo J. O., “Alcohol Use in Pregnancy,” Clinical Obstetrics & Gynecology 62 (2019): 142–155. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 43. Guerri C. and Pascual M., “Effects of Alcohol on Embryo/Fetal Development” in Reproductive Toxicology, ed. Gupta R. C. (2022), 379–394. [Google Scholar]
- 44. Bhatia S., Drake D. M., Miller L., Wells P. G., et al., “Oxidative Stress and DNA Damage in the Mechanism of Fetal Alcohol Spectrum Disorders,” Birth Defects Research 111 (2019): 714–748. [DOI] [PubMed] [Google Scholar]
- 45. Sulik K. K., “Fetal Alcohol Spectrum Disorder: Pathogenesis and Mechanisms,” Handbook of Clinical Neurology 125 (2014): 463–475. [DOI] [PubMed] [Google Scholar]
- 46. Lipinski R. J., Hammond P., O'Leary‐Moore S. K., et al., “Ethanol‐Induced Face‐Brain Dysmorphology Patterns Are Correlative and Exposure‐Stage Dependent,” PLoS One 7 (2012): e43067. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 47. De La Monte S. M. and Kril J. J., “Human Alcohol‐Related Neuropathology,” Acta Neuropathologica 127 (2014): 71–90. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 48. Simet S., “Alcohol's Effects on Lung Health and Immunity,” Alcohol Research: Current Reviews 37 (2015): 199. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 49. Ungerer M., “In Utero Alcohol Exposure, Epigenetic Changes, and Their Consequences,” Alcohol Research: Current Reviews 35 (2013): 37. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 50. Fan J., Jacobson S. W., Taylor P. A., et al., “White Matter Deficits Mediate Effects of Prenatal Alcohol Exposure on Cognitive Development in Childhood,” Human Brain Mapping 37 (2016): 2943–2958. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 51. Donald K. A., Fouche J. P., Roos A., et al., “Alcohol Exposure in Utero Is Associated With Decreased Gray Matter Volume in Neonates,” Metabolic Brain Disease 31 (2015): 81–91. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 52. Meombe Mbolle A., Thapa S., Bukiya A. N., and Jiang H., “High‐Resolution Imaging in Studies of Alcohol Effect on Prenatal Development,” Advances in Drug and Alcohol Research 3 (2023): 10790. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 53. Eberhart J. K. and Parnell S. E., “The Genetics of Fetal Alcohol Spectrum Disorders,” Alcoholism: Clinical and Experimental Research 40 (2016): 1154–1165. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 54. Wojtyła A., Kapka‐Skrzypczak L., Diatczyk J., Fronczak A., and Paprzycki P., “Alcohol‐Related Developmental Origin of Adult Health–Population Studies in Poland Among Mothers and Newborns (2010‐2012),” Annals of Agricultural and Environmental Medicine 19 (2012): 365–377. [PubMed] [Google Scholar]
- 55. Bandoli G., Coles C. D., Kable J. A., et al., “Patterns of Prenatal Alcohol Use That Predict Infant Growth and Development,” Pediatrics 143 (2019): e20182399. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 56. O'Keeffe L. M., Kearney P. M., Greene R. A., and Kenny L. C., “Alcohol Use During Pregnancy,” Obstetrics, Gynaecology & Reproductive Medicine 26 (2016): 188–189. [Google Scholar]
- 57. Mamluk L., Edwards H. B., Savović J., et al., “Low Alcohol Consumption and Pregnancy and Childhood Outcomes: Time to Change Guidelines Indicating Apparently ‘Safe’ levels of Alcohol During Pregnancy? A Systematic Review and Meta‐Analyses,” BMJ Open 7 (2017): 015410. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 58. Sowell K., Holt R., Uriu‐Adams J., et al., “Alcohol Consumption and Smoking During Pregnancy Alters Maternal Plasma Fatty Acid Composition: Association With Fetal Alcohol Spectrum Disorders (P11‐028‐19),” Current Developments in Nutrition 3 (2019). [DOI] [PMC free article] [PubMed] [Google Scholar]
- 59. BMA Board of Science , Fetal Alcohol Spectrum Disorders, a Guide for Healthcare Practitioners Update (British Medical Association, 2016). [Google Scholar]
- 60. Hoyme H. E., Kalberg W. O., Elliott A. J., et al., “Updated Clinical Guidelines for Diagnosing Fetal Alcohol Spectrum Disorders,” Pediatrics 138 (2016): e20154256. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 61. Suttie M. F., Image‐Based Detection of Neuro‐Facial Differences in Foetal Alcohol Spectrum Disorders (University College London, 2018).
- 62. Lange S., Probst C., Gmel G., Rehm J., Burd L., and Popova S., “Global Prevalence of Fetal Alcohol Spectrum Disorder Among Children and Youth: A Systematic Review and Meta‐Analysis,” JAMA Pediatrics 171 (2017): 948–956. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 63. Roozen S., Peters G.‐J. Y., Kok G., Townend D., Nijhuis J., and Curfs L., “Worldwide Prevalence of Fetal Alcohol Spectrum Disorders: A Systematic Literature Review Including Meta‐Analysis,” Alcoholism: Clinical and Experimental Research 40 (2016): 18–32. [DOI] [PubMed] [Google Scholar]
- 64. McQuire C., Mukherjee R., Hurt L., et al., “Screening Prevalence of Fetal Alcohol Spectrum Disorders in a Region of the United Kingdom: A Population‐Based Birth‐Cohort Study,” Preventive Medicine 118 (2019): 344–351. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 65. Martin J. A., Hamilton B. E., Osterman M. J. K., et al., Births: Final Data for 2018 (National Center for Health Statistics (US), 2019), https://stacks.cdc.gov/view/cdc/231883. [PubMed]
- 66. May P. A., Chambers C. D., Kalberg W. O., et al., “Prevalence of Fetal Alcohol Spectrum Disorders in 4 US Communities,” Journal of the American Medical Association 319 (2018): 474–482. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 67. Popova S., Lange S., Burd L., and Rehm J., “Cost Attributable to Fetal Alcohol Spectrum Disorder in the Canadian Correctional System,” International Journal of Law and Psychiatry 41 (2015): 76–81. [DOI] [PubMed] [Google Scholar]
- 68. Hasan N., Curran S., Jhass A., Poduval S., Legido‐Quigley H., and Crisp N., “The UK's Strong Contribution to Health Globally,” Lancet 386 (2015): 117–118. [DOI] [PubMed] [Google Scholar]
- 69. Popova S., Lange S., Burd L., et al., “Burden and Social Cost of Fetal Alcohol Spectrum Disorders,” in Oxford Handbook Topics in Psychology (Oxford University Press, 2016). [Google Scholar]
- 70. McLean S. and McDougall S., “Fetal Alcohol Spectrum Disorders: Current Issues in Awareness, Prevention and Intervention,” CFCA Paper (2014): 19. [Google Scholar]
- 71. Popova S., Dozet D., and Burd L., “Fetal Alcohol Spectrum Disorder: Can We Change the Future?,” Alcoholism: Clinical and Experimental Research 44 (2020): 815–819. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 72. May P. A., de Vries M. M., Marais A. S., et al., “The Prevalence of Fetal Alcohol Spectrum Disorders in Rural Communities in South Africa: A Third Regional Sample of Child Characteristics and Maternal Risk Factors,” Alcoholism: Clinical and Experimental Research 46 (2022): 1819–1836. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 73. Olivier L., Curfs L. M. G., and Viljoen D. L., “Fetal Alcohol Spectrum Disorders: Prevalence Rates in South Africa,” South African Medical Journal 106 (2016): 103–106. [DOI] [PubMed] [Google Scholar]
- 74. Adnams C. M., “Fetal Alcohol Spectrum Disorder in Africa,” Current Opinion in Psychiatry 30 (2017): 108–112. [DOI] [PubMed] [Google Scholar]
- 75. World Health Organization , “Maternal Health,” 2024, https://www.who.int/health-topics/maternal-health.
- 76. Skagerstróm J., Chang G., and Nilsen P., “Predictors of Drinking During Pregnancy: A Systematic Review,” Journal of Women's Health 20 (2011): 901–913. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 77. Liew H., “The Effects of Marital Status Transitions on Alcohol Use Trajectories,” Longit Life Course Stud 3 (2012): 332–345. [Google Scholar]
- 78. Brisibe S. and Ordinioha B., “Socio‐Demographic Characteristics of Alcohol Abusers in a Rural Ijaw Community in Bayelsa State, South‐South Nigeria,” Annals of African Medicine 10 (2011): 97. [DOI] [PubMed] [Google Scholar]
- 79. Nizhnikov M. E., Popoola D. O., and Cameron N. M., “Transgenerational Transmission of the Effect of Gestational Ethanol Exposure on Ethanol Use‐Related Behavior,” Alcoholism: Clinical and Experimental Research 40 (2016): 497–506. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 80. Thompson A., Hackman D., and Burd L., “Mortality in Fetal Alcohol Spectrum Disorders,” Open Journal of Pediatrics 04 (2014): 21–33. [Google Scholar]
- 81. Schwart M., Hart B., Weyrauch D., et al., “The Hidden Face of Fetal Alcohol Spectrum Disorder,” Current Women's Health Reviews 13 (2017): 96–102. [Google Scholar]
- 82. Popova S., Dozet D., Shield K., Rehm J., and Burd L., “Alcohol's Impact on the Fetus,” Nutrients 13 (2021): 3452. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 83. Gómez‐Roig M. D., Pascal R., Cahuana M. J., et al., “Environmental Exposure During Pregnancy: Influence on Prenatal Development and Early Life: A Comprehensive Review,” Fetal Diagnosis and Therapy 48 (2021): 245–257. [DOI] [PubMed] [Google Scholar]
- 84. O'Leary C., Nassar N., Kurinczuk J., and Bower C., “The Effect of Maternal Alcohol Consumption on Fetal Growth and Preterm Birth,” BJOG: An International Journal of Obstetrics & Gynaecology 116 (2009): 390–400. [DOI] [PubMed] [Google Scholar]
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