Skip to main content
BMC Public Health logoLink to BMC Public Health
. 2026 Jun 19;26:2793. doi: 10.1186/s12889-026-28109-2

Interventions involving community health workers and their effect on cervical cancer screening uptake in sub-Saharan Africa: a systematic review

Sophie Hilda Lemoupa Makajio 1,2,3,✉, Micol Murtas 3, Bruno Kenfack 4, Pierre Vassilakos 5, Nicole C Schmidt 3,6, Patrick Petignat 3, Ania Wisniak 1,3
PMCID: PMC13637286  PMID: 42321728

Abstract

Background

Sub-Saharan Africa (SSA) has the highest incidence and mortality rates of cervical cancer (CC), largely due to limited screening coverage. Community health workers (CHWs) are lay health providers who strengthen healthcare delivery; however, their influence on cervical cancer screening (CCS) uptake remains insufficiently explored. This systematic review evaluates the impact of CHW-involved interventions on CCS uptake in SSA.

Methods

A systematic search of MEDLINE, EMBASE, and Cochrane databases was conducted in June 2023 and updated in May 2025. Studies were included if they: (1) were conducted in SSA among females eligible for CCS and published between January 2003 and May 2025; (2) compared CHW-based interventions with standard or non-CHW approaches; and (3) reported CCS uptake, linkage to triage and/or treatment after primary screening or attendance to follow-up visits. Only studies using a controlled design were included. A descriptive analysis was performed. PROSPERO registration: CRD42024495220.

Results

Six studies met the inclusion criteria. Despite methodological limitations, all studies involved CHWs in health education and counseling. CHWs conducted home visits to recruit participants for CCS, rescheduled follow-up appointments, facilitated access to care, and provided childcare during screening attendance. Interventions involving CHWs significantly increased CCS uptake in three of the five studies assessing it as the primary outcome and improved follow-up attendance in the single study examining this indicator.

Conclusion

The effectiveness of CHW-based interventions varies by type and context but shows potential to enhance CCS uptake in SSA.

Keywords: Cervical cancer screening, Community health workers, Sub-Saharan Africa

Introduction

Cervical cancer (CC) is the fourth most common cancer among women worldwide, with an estimated 660,000 new cases and 350,000 deaths reported in 2022 [1]. CC results from persistent infection with oncogenic human papilloma virus (HPV) [2], and sub-Saharan Africa (SSA) continues to experience the highest incidence and mortality rates [1]. To accelerate CC elimination, the World Health Organization (WHO) established 2030 targets: 90% of girls should be fully vaccinated against HPV before age 15 years, 70% of females screened with a high-performance test at ages 35 and 45 years, and 90% of those diagnosed with cervical disease receiving treatment [3].

Screening is fundamental to CC prevention because the disease progresses slowly. Early detection of precancerous lesions enables treatment before invasive cancer develops, reducing the need for resource-intensive care [4]. However, cervical cancer screening (CCS) uptake averages 19% in low-income countries compared with 63% in high-income countries [5]. A systematic review and meta-analysis of CCS coverage in SSA reported a pooled uptake of 12.9%, with considerable variation across countries [6]. Major barriers include limited access to screening services, low awareness and knowledge of CC, and socio-cultural constraints [7]. From the provider perspective, insufficient skills, inadequate equipment, and staff shortages impede effective CCS delivery [7]. The COVID-19 pandemic further reduced attendance at hospital-based screening units [8], highlighting the urgency of community-based strategies to improve coverage.

Community health workers (CHWs) are healthcare providers who reside within the communities they serve and generally possess less formal education and training than professional healthcare staff such as nurses and physicians [9]. In SSA, CHWs have been instrumental in strengthening the heath care workforce and improving access and outcomes across programs addressing immunization [10, 11], malaria [12] and HIV [13]. Nevertheless, evidence on the influence of CHWs on CCS uptake remains limited. This systematic review aimed to assess the effect of CHWs involvement on CCS uptake in SSA and related outcomes. Specifically, this review assessed whether CHW-led or CHW-supported interventions improve screening participation compared to standard care, identify which CHW activities are associated with increased uptake, and examine contextual factors influencing their effectiveness. By synthesizing available evidence, this study sought to clarify the potential contribution of CHWs to enhancing the reach, equity and effectiveness of cervical cancer screening programs in SSA. The review follows the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) 2020 guidelines [14].

Methods

Search strategy

A systematic literature search was conducted in June 2023 and updated in May 2025 using MEDLINE, EMBASE, and the Cochrane Library (Cochrane Database of Systematic Reviews and Cochrane Central Register of Controlled Trials). Reference lists of eligible studies and relevant review articles were also screened for additional publications. Articles written in or translated into English or French and published between January 2003 and May 2025 were eligible. Unpublished studies were excluded.

The search strategy combined exploded MeSH and Emtree terms with free‑text synonyms for “cervical cancer” and “community health workers”; complete Boolean search strings for each database are provided in the Appendix 1. Eligible studies employed controlled designs evaluating CHW-based interventions, including randomized trials, cohort studies, before-after studies, and cross-sectional or case-control studies with a comparison group. Reviews, meta-analyses, commentaries, qualitative studies without quantitative components, study protocols, conference papers and abstracts were excluded.

Eligibility criteria

Studies were eligible if participants were females living in SSA who met the criteria for CCS. Those involving females with a history of total hysterectomy or prior diagnosis were excluded. Interventions conducted at any level of the health care system – primary, secondary, tertiary- or within the community level, were eligible. Only studies conducted in SSA were included, based on the country information provided in the publication or its supplementary materials. Countries in SSA were defined according to the World Bank classification. The full list of countries is provided in Appendix 2.

CHWs were identified using the WHO definition. Equivalent designations, such as health auxiliaries, field workers, outreach workers, village health workers, lay health workers, community health aides or community promoters were accepted when descriptions aligned with the WHO definition.

Interventions involving CHWs were defined as activities led or supported by CHWs at any stage of CCS procedures, including population sensitization, recruitment of eligible females, specimen collection, screening test administration, and follow-up. Multifaceted strategies were eligible if CHWs participated in at least one component.

Comparators were CCS strategies that did not involve CHWs, including standard facility-based approaches or study interventions delivered without CHW participation.

The following outcomes were extracted for each study: the primary outcome was CCS uptake, defined as the proportion of eligible females who underwent screening during the study-defined period. Secondary outcomes included linkage to triage or treatment after initial screening, attendance at follow-up visits, and self-reported intention to undergo CCS.

Study selection

Two reviewers (SLM and AW) independently screened article titles and abstracts using Covidence software (www.covidence.org) to identify studies meeting the eligibility criteria. Discrepancies in judgement were resolved through discussion with a third reviewer (MM).

Risk of bias assessment

Risk of bias was assessed using the Cochrane Risk of Bias 2 (Rob2) tool for randomized controlled trials and the Risk of Bias in Non-randomized Studies of Interventions (Robins-I) tool for non-randomized studies. The Rob2 tool evaluates five domains: (1) bias arising from the randomization process; (2) bias due to deviations from the intended interventions; (3) bias due to missing outcome data; (4) bias in outcome measurement; and (5) bias in selection of the reported result. Each domain was rated as “low risk,” “some concerns,” or “high risk.” The (ROBINS-I) tool assesses seven domains: (1) bias due to confounding; (2) bias in participant selection; (3) bias in classification of interventions; (4) bias due to deviations from intended interventions; (5) bias due to missing data; (6) bias in outcome measurement; and (7) bias in selection of the reported result. Each domain was judged as “low risk,” “moderate risk,” “serious risk,” “critical risk,” or “no information.” Two reviewers (SLM and MM) independently evaluated each study, with a third reviewer (AW) resolving any disagreement.

Data extraction

The following data were extracted from eligible studies: title, first author, publication year, study design, study period, country, setting (urban vs. rural setting; community- or facility-based, study population (age group), number of participants in intervention and control groups, type of intervention, comparator, number of females screened (primary outcome), and number followed up (secondary outcome).

Data extraction was undertaken independently by two reviewers. Discrepancies were resolved through discussion with a third reviewer. The final dataset was exported from Covidence in Excel format. Missing data were recorded and reported as such.

Strategy for data synthesis

A narrative synthesis was conducted to summarize the findings of included studies. The synthesis was organized according to study characteristics: (1) type of intervention (e.g., door-to-door recruitment, community events), and (2) study outcomes (e.g., screening uptake, linkage to triage and/or treatment among screen-positive females).

Review registration

The review protocol was retrospectively registered with the International Prospective Register of Systematic Reviews (PROSPERO) on 26 January 2024, CRD42024495220. At the time of submission, formal literature searches had begun; however, screening of search results against the inclusion criteria had not yet been performed.

Results

No additional studies meeting the inclusion criteria were published between June 2023 and May 2025. The initial search through electronic databases identified 726 records. After Covidence automatically removed 398 duplicates, 315 records were excluded during title and abstract screening because they did not meet the eligibility criteria. The remaining 13 records underwent full-text review, of which nine were excluded for the following reasons: study protocol (n = 2), poster abstract (n = 1), inappropriate outcomes (n = 1), unsuitable comparators (n = 1), irrelevant intervention (n = 1), incomplete data (n = 2), and duplicate data (n = 1). Manual reference searching identified four additional records, two of which were excluded after screening. In total, six studies met all inclusion criteria and were included in this review. The study selection process is illustrated in the PRISMA flow diagram (Fig. 1).

Fig. 1.

Fig. 1

Study flow chart. The article selection process is illustrated according to the PRISMA 2020 flow. The literature search identified 726 records by electronic databases, and 4 records were identified by manual reference screening, yielding a total of 730 records. Six studies met the inclusion criteria and were retained for analysis

Study characteristics

The six included studies involved 9,192 participants, with individual sample sizes ranging from 88 to 5,772 participants. The studies were published between 2003 and 2023. Two were conducted in South- Africa (33.3%), one in Central Africa: (Cameroon, 16.7%), one in West Africa (Nigeria, 16.7%), and two in East Africa (Tanzania and Kenya, 16.7% each). Five studies were community based, and one was facility based. Settings included urban (n = 1, 16.7%), rural settings (n = 2, 33.3%), peri-urban settings (n = 2, 33.3%) and mixed urban-rural settings (n = 1, 16.7%). Two studies (33.3%) used before-after designs, two were randomized controlled trials (33.3%) and two were prospective cohort studies (33.3.%). Participants were females aged 20–65 years (Table  1).

Table 1.

Profile of included studies and key findings

Author, Country, Year, Study design, setting, study duration, sample size Population Intervention (I) /Comparator (C) Outcome/Results
Goldhaber-Fiebert et al., South-Africa (2009) [15]

Prospective cohort study

Community-based

Peri-urban

Duration: 2 years

Sample size:

6 months: 1,003

12 months: 1,992

24 months: 1,969

36 months: 808

Females aged 35–65 years

I: Home visits to reschedule appointments and encourage attendance with CHW visits repeated until return is achieved, or further participation is declined.

C: Follow-up without CHWs’ visit

Outcome: Attendance of scheduled follow-up visits at 6, 12, 24 and 36 months.

Outcome ascertainment: through study appointments database and CHWs records

Results:

6 months:

I:907/1,003 (90%)

C:740/1,003 (74%)

12 months:

I: 1,739/1,992 (87%)

C: 1,096/1,992 (55%)

24 months:

I: 1,518/1,969 (77%)

C: 944/1,969 (48%)

36 months:

I:647/808 (80%)

C: 453/808 (56%)

Mbach u et al., Nigeria (2017) [16]

Before and after design Community-based in Anglican churches

Urban

Duration: unknown

Sample size: (n = 300)

Females aged 21 years I: Peer health education on CC attended during 3 to 6 sessions.

Outcome: CCS uptake.

Outcome ascertainment: through interview

Results:

Before: 30/285 (10.5%)

After: 49/283 (17.3%)

Significant increase in CC screening of + 6.8% (p = 0.02).

Mboineki et al., Tanzania (2022) [17]

Randomized controlled trial

Community-based

Urban

Duration: 6 months

Sample size:

I: 44

C: 44

Females aged 21–50

I: Health education by CHWs about CC and CCS; counselling for females who did not undergo screening, navigation support and childcare assistance for mothers attending screening.

C: Health education on CC and its prevention through the ongoing national CCS awareness campaign and other channels

Outcomes:

-CCS uptake at 6 months follow-up.

-CCS intention at 3- and 6-months follow-up

Outcome ascertainment: through interview

Results:

CCS uptake:

3 months follow-up:

I: 29/44 (65.9%)

C: 1/44 (2.3%)

6 months follow-up:

I: 32/44 (72.7%)

C: 1/44 (2.3%)

CCS intention score:

Baseline (T0): No significant difference in CCS intention between I (86.1 ± 17.4) and C (86.6 ± 0.23.5)

3 months follow-up (T1):

I: 141.7 ± 7.5

C: 86.6 ± 23.5

6 months follow-up (T2):

I:145.2 ± 5.3

C:86.6 ± 23.5

(p < 0.001)

Pham et al., Cameroon

(2022) [18]

Before and after design

Community-based

Rural

Duration:18 months

Sample size: (n = 1940)

Females aged 30–49 years

I: CHW-led: door-to-door sensitization, invitation vouchers for CCS given to eligible females

C: CIC led: radio announcement, street banners, flyers, posters in public places

Outcome: CCS uptake

Outcome ascertainment: screening centre records

Results:

I: 584/1,940 (30.1%)

C: 1356/1,940 (69.9%)

Proportion of screened females living in rural areas increased from 12.1% to 61.4% among all females screened in CIC-led and CHW-led respectively.

Rosser et al., Kenya (2015) [19]

Randomized controlled trial

Facility-based

Rural

Duration: 5 months

Sample size:

I: 207

C: 212

Females aged ≥ 23 years

I: 30-minute interactive talk about CC by CHWs

C: No health talk

Outcome: CCS uptake

Outcome ascertainment: through interview and health facilities records

Results:

I: 122/207 (58.9%)

C: 129/212 (60.9%)

No statistically significant difference between the two groups

Tum et al., South-Africa (2013) [20]

Before and after design, Community-based

Urban

Duration: 8 months

Sample size: 673

Females aged ≥ 20 years I: Community health education on CC and breast cancer, home visits and encouraging uptake of CC screening

Outcome: CCS uptake

Outcome ascertainment: records of the Cancer Nursing Community of Practice and available statistics

Result:

Before: 1.3%

After: 21/673 (3.1%)

CC Cervical Cancer, CCS Cervical Cancer Screening, CHWs Community Health Workers, CIC Communication Information Channels, I Intervention, C Control, PNLav Peer-Led Navigation

Type of interventions carried out by CHWs

Across all included studies, CHWs participated in health education and counselling [15–20]. In four studies, CHWs performed visits aiming to recruit participants [18, 20], to reschedule follow-up [15], assist with navigation to healthcare facilities [17] or provide childcare while mothers attended screening sessions [17].

Study outcomes

Five studies [16–20] assessed the effect of CHW interventions on CCS uptake as the primary outcome, and one [15] evaluated attendance at scheduled follow-ups. CHW involvement improved CCS uptake from 10.5% to 17.3% in Nigeria [16], and from 12.1% to 61.4% of females in rural Cameroon [18]. In Tanzania, 73% of females who received a peer-led navigation (PLNav) intervention underwent CCS compared with 2.3% in the control group [17]. In contrast, CHWs interventions in Kenya [19] and South Africa [20] showed no significant difference in CCS uptake. In another study in South Africa [15], 74%, 55%, 48%, and 56% of females attended their scheduled 6-, 12-, 24-, and 36-months appointments without CHWs’ contact, versus 90%, 83%, 74%, and 77% respectively after two CHW’s visits.

The Tanzanian study also reported a PLNav intervention’s effect on CCS intention as a secondary outcome. Screening intention was determined by composite scores of CCS attitude, subjective norms, and perceived behavioral control. At baseline, intention did not differ between groups; however at 3 and 6 months after the PLNav, the intervention group showed significantly higher intention scores (T0 = 86.1 ± 17.4, T1 = 141±7.5, and T2 = 145.2 ± 5.3) compared with the control group intention score (T0 = 85.4 ± 23.9, T1 = 86.8 ± 23.5, and T2 = 86.6 ± 23.5) [F(1,43) = 106.6, p < 0.01] [17].

Quality assessment of the studies

Among the non-randomized studies, one demonstrated an overall critical risk of bias, two showed an overall serious risk, and one presented a moderate risk of bias ( Fig. 2).

Fig. 2.

Fig. 2

Analysis of risk of bias among the included studies using the ROBINS-I tool

The randomized controlled trial conducted in Tanzania exhibited an overall moderate risk of bias, whereas the trial performed in Kenya demonstrated a low risk of bias (Table 2).

Table 2.

Quality assessment of included studies using the RoB 2 tool

Cochrane Risk of Bias 2
Randomization process Deviations from the intended interventions Missing out come data Outcome measurement Selection of the reported result Overall risk of bias assessment
Mboineki et al., 2022 Low Low Low High Some concerns Moderate
Rosser et al., 2015 Low Low Low Low Some concerns Low

Discussion

This systematic review examined the effects of CHW interventions on CCS uptake in SSA. Six studies met the inclusion criteria. All studies involved CHWs in health education and counseling [15–20]. Other activities included: home visits [18, 20], navigation to care [17], invitation for screening [18] and follow-up [15]. Interventions involving CHWs significantly increased CCS uptake in three of the five studies assessing it as the primary outcome [16–18] and improved follow-up attendance in the single study examining this indicator [15].

The included studies were implemented either as standalone or multi-component strategies. In all studies, CHWs delivered health education on CC and screening across diverse settings, including health facilities [19], churches [16] and within homes or communities [15, 17, 18, 20]. The outcomes of these interventions varied by context. Health education, alone or combined with other strategies, effectively increased CCS uptake in urban Nigeria [16], Tanzania [17], and rural Cameroon [18]. However, a 30-minute interactive education session in rural Kenya did not yield a statistically significant improvement [19]. In Iran, CHW-led education interventions based on protection motivation theory enhanced Pap test use [21], and in the United States, a CHW-led intervention among Hispanic females increased Pap screening rates, knowledge, and self-efficacy [22]. These findings indicate that CHW-led education effectiveness may depend on geographic, infrastructural, individual, or cultural factors.

The association between knowledge and screening uptake is complex. High awareness does not always translate to participation. Among female health workers in Nigeria, 98% reported awareness, yet 19.8% had been screened, citing barriers such as fear of complications and high costs [23]. Similarly, among mothers attending antenatal and postnatal clinics, awareness was moderate (59.8%) but screening remained low (36.1%) [24]. Barriers to CC screening in SSA are well documented and include logistical, cultural, and systemic factors [7, 25]. To address these challenges, CHWs must possess not only biomedical knowledge but also strong communication and motivational skills. For instance, motivational interviewing- delivered face-to-face or by telephone- has improved screening uptake for breast and cervical cancers screening [26].

Although initial training is essential, continuous assessment and supervision are equally critical for maintaining CHW performance [27]. Studies in Nigeria [16] and Tanzania [17] did not specify whether CHW competencies were assessed before and after training, or describe supervision during implementation. Financial motivation also influences CHW performance [27, 28 ]. In Cameroon, CHWs were paid per recruited participant [18], whereas in Nigeria [16] and South-Africa [20], they received only transport reimbursement during training. Despite differing incentive structures, all three interventions improved screening uptake. This suggests that factors beyond financial incentives—such as training quality, community trust, supervision, and intrinsic motivation—may be crucial in driving CHW effectiveness [29]. The influence of incentives may also depend on the broader CHW financing and employment systems.

Home visits and community sensitization are increasingly used for CCS in SSA. CHWs often conduct door-to-door enumeration and education before screening campaigns [30–32], fostering trust and open communication. Home-visits allowed to effectively rescheduled appointments and encourage attendance among participants lost to follow-up [15], while PLNav improved CCS uptake [17]. In Cameroon, invitation vouchers distributed after door-to-door sensitization increased screening uptake among rural females [18]. In the EMA study in Argentina, home-based self-collection for HPV testing provided by CHWs during home visits produced a four-fold increase in CCS compared with invitation vouchers issued after health education sessions [33]. A multicomponent intervention comprising health education, monthly telephone follow-ups, and navigation assistance also improved CCS uptake among South-Asian women in Hong-Kong [34].

None of the included studies formally assessed CHW workload in CC prevention or reported whether the CC-related activities were integrated with other health programs. However, a time-and-motion study in Malawi demonstrated that integrating CC prevention activities with other health program responsibilities is feasible, when CHWs receive close supervision and effective time management support [35].

This review has several limitations. Despite identifying many articles, few met the inclusion criteria, limiting analysis to a descriptive synthesis. The risk-of-bias assessment revealed multiple methodological concerns. All the non-randomized studies included were judged to have serious to critical bias due to confounding which may have led to overestimation or underestimation of the true effect of the intervention [15, 16, 18, 20]. This is particularly important given the observational nature of these studies and the likelihood that key confounders were not fully accounted for. The two included randomized controlled trials were judged to have ‘some concerns’ regarding selection of the reported results, reflecting limited information on pre-specified outcomes and analyses [17, 19]. This raises the possibility of selective reporting, which may have influenced the results.

Nonetheless, a strength of this review is the inclusion of studies comparing CHW-led interventions to standard procedures or interventions without CHWs, allowing evaluation of their specific contributions. The findings underscore the need for robust comparative studies to clarify CHWs’ impact on CCS uptake in SSA.

While CHW-based interventions show potential to improve CCS [15–18], their effectiveness appears to depend on contextual factors including training, supervision, intrinsic motivation and health system [27, 29]. Task shifting to CHWs can therefore be a viable strategy for addressing health personnel shortage, but only when implemented with adequate resources and oversight. These results highlight the importance of developing well-structured community health workforce policies that ensure proper training, supervision, and integration of CHWs into formal health systems in SSA.

Conclusions

In SSA, CHWs primarily support CC screening through health education, home visits, invitation for screening, navigation to care, and follow-up. The effectiveness of these interventions varies by type and setting. While evidence suggests that CHWs can enhance screening uptake, further rigorous research is needed to confirm these effects and elucidate underlying mechanisms.

Abbreviations

CC

Cervical Cancer

CCS

Cervical Cancer Screening

CHW

Community Health Worker

PLNav

Peer Led Navigation

RoB

Risk of Bias

SSA

Sub-Saharan Africa

WHO

World Health Organization

PRISMA

Preferred Reporting Items for Systematic Reviews and Meta-Analysis

Appendix

Appendix 1

Search strategy

The following searches were conducted for the key terms “cervical cancer” and “community health workers” including their variations and equivalent MeSH terms.

MEDLINE:

  • ("uterine cervical neoplasms"[MeSH Terms] OR ("cervi*"[All Fields] AND "cancer"[All Fields]) OR ("cervi*"[All Fields] AND "neoplas*"[All Fields]) OR ("cervi*"[All Fields] AND "dysplas*"[All Fields]))

  • AND ("community health workers"[MeSH Terms] OR "community health worker*"[All Fields] OR "outreach worker*"[All Fields] OR "field worker*"[All Fields] OR “health auxiliar*”[All Fields])

EMBASE:

  • ('cervical cancer'/exp OR ('cervi*' AND 'cancer') OR ('cervi*' AND 'neoplas*') OR ('cervi*' AND 'dysplas*'))

  • AND ('community health worker*' OR 'outreach worker*' OR 'field worker*' OR 'health auxiliar*')

Cochrane Library:

  •  #1 MeSH descriptor: [Uterine Cervical Neoplasms] explode all trees

  • #2 MeSH descriptor: [Uterine Cervical Dysplasia] explode all trees

  • #3 (cervi* NEAR (cancer or neoplas* or dysplas*)) (Word variations have been searched)

  • #4 #1 OR #2 OR #3

  • #5 MeSH descriptor: [Community Health Workers] explode all trees

  • #6 (community NEXT health NEXT worker*) OR (community NEXT worker*) OR (outreach NEXT worker*) OR (health NEXT auxiliar*) OR (field NEXT worker*) (Word variations have been searched)

  • #7 #5 OR #6

  • #8 #4 AND #7 with Cochrane Library publication date Between Jan 2003 and May 2023

Appendix 2

Participants/population

Eligibility for this review was based on the World Bank list of countries classified as part of Sub-Saharan Africa. These include Angola, Benin, Botswana, Burkina Faso, Burundi, Cabo Verde, Cameroon, Central African Republic, Chad, Comoros, Congo, Democratic Republic of, Congo, Republic of Cote d'Ivoire, Equatorial Guinea, Eritrea, Eswatini (Formerly Known as Swaziland), Ethiopia, Gabon, Gambia, Ghana, Guinea, Guinea-Bissau, Kenya, Lesotho, Liberia, Madagascar, Malawi, Mali, Mauritania, Mauritius, Mozambique, Namibia, Niger, Nigeria, Rwanda, Sao Tome and Principe, Senegal, Seychelles, Sierra Leone, Somalia, South Africa, South Sudan, Sudan, Tanzania, Togo, Uganda, Zambia, Zimbabwe.

Authors’ contributions

PP, SLM and AW designed the study. PP and NS oversaw the study and its execution. SLM and AW were the two reviewers that assessed all the articles for inclusion criteria. SLM and MM did the risk of bias analysis and AW was the third reviewer called in case of disagreement between the two first reviewers. SLM did data analysis. All authors reviewed the manuscript.

Funding

The authors received no financial support for the research, authorship, or publication of this article. SLM is Scholar of GlobalP3HS fellowship program for PhD study in public health in Switzerland. Her PhD salary was also partially funded by “Commune de Cologny” and “Commission des Affaires Humanitaires des HUG”. AW salary is funded by “Maurice Chalumeau Center for Sexuality Studies (University of Geneva)”.

Data availability

Data is provided within the manuscript or supplementary information files.

Declarations

Ethics approval and consent to participate

Not applicable.

Consent for publication

Not applicable.

Competing interests

The authors declare no competing interests.

Footnotes

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

References

  • 1.Bray F, Laversanne M, Sung H, Ferlay J, Siegel RL, Soerjomataram I, et al. Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA: A Cancer. J Clin. 2024;74(3):229–63. [DOI] [PubMed] [Google Scholar]
  • 2.Walboomers JMM, Jacobs MV, Manos MM, Bosch FX, Kummer JA, Shah KV, et al. Human papillomavirus is a necessary cause of invasive cervical cancer worldwide. J Pathol. 1999;189(1):12–9. [DOI] [PubMed] [Google Scholar]
  • 3.Global strategy to accelerate the elimination of cervical cancer as a public health problem. 1st ed. Geneva: World Health Organization; 2020. p. 1.
  • 4.Rodriguez NM. Participatory innovation for human papillomavirus screening to accelerate the elimination of cervical cancer. Lancet Global Health. 2021;9(5):e582–3. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 5.Gakidou E, Nordhagen S, Obermeyer Z. Coverage of cervical cancer screening in 57 countries: low average levels and large inequalities. PLOS Med. 2008;5(6):e132. [DOI] [PMC free article] [PubMed]
  • 6.Yimer NB, Mohammed MA, Solomon K, Tadese M, Grutzmacher S, Meikena HK, et al. Cervical cancer screening uptake in sub-Saharan Africa: a systematic review and meta-analysis. Public Health. 2021;1:195:105–11. [DOI] [PubMed]
  • 7.Mantula F, Toefy Y, Sewram V. Barriers to cervical cancer screening in Africa: a systematic review. BMC Public Health. 2024;24(1):525. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 8.Sormani J, Datchoua AM, Petignat P, Kenfack B, Schmidt NC. Effects of the COVID-19 pandemic on an urban cervical cancer screening program in West Cameroon. Int J Gynecol Cancer. 2021;31(9):1297–8. [DOI] [PMC free article] [PubMed]
  • 9.What do we know about community health. workers? A systematic review of existing reviews. Available from: https://www.who.int/publications/i/item/what-do-we-know-about-community-health-workers-a-systematic-review-of-existingreviews. [cited 2025 Apr 11]. Assessed 2025 Apr 11.
  • 10.Ogutu EA, Ellis AS, Hester KA, Rodriguez K, Sakas Z, Jaishwal C, et al. Success in vaccination programming through community health workers: a qualitative analysis of interviews and focus group discussions from Nepal, Senegal and Zambia. BMJ Open. 2024;14(4):e079358. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 11.Ouédraogo HS, Kabore YLB, Sawadogo AG, Bakouan M, Sawadogo N, Mano M et al. Task-shifting immunization activities to community health workers: A mixed-method cross-sectional study in Sahel Region, Burkina Faso. Glob Health Sci Pract. 2023;11(5). https://www.ghspjournal.org/content/11/5/e2300044. Accessed 2025. [DOI] [PMC free article] [PubMed]
  • 12.Smith Paintain LS, Willey B, Kedenge S, Sharkey A, Kim J, Buj V et al. Community health workers and stand-alone or integrated case management of malaria: A systematic literature review. Am J Trop Med Hyg. 2014;91(3):461–70. [DOI] [PMC free article] [PubMed]
  • 13.Abdullateef RO, Esanju DO, Akintola AA, Salako OO, Akin-Ajani O. Community health workers’ commitment to HIV/AIDS control in Africa. J Med Surg Public Health. 2024;2:100036. [Google Scholar]
  • 14.Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ. 2021;372:n71. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 15.Goldhaber-Fiebert JD, Denny LA, De Souza MD, Kuhn L, Goldie SJ. Program spending to increase adherence: South African cervical cancer screening. PLoS ONE. 2009;4(5):e5691. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 16.Mbachu C, Dim C, Ezeoke U. Effects of peer health education on perception and practice of screening for cervical cancer among urban residential women in south-east Nigeria: a before and after study. BMC Womens Health. 2017;17(1):41. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 17.Mboineki JF, Wang P, Dhakal K, Getu MA, Chen C. The effect of peer-led navigation approach as a form of task shifting in promoting cervical cancer screening knowledge, intention, and practices among urban women in Tanzania: A randomized controlled trial. Cancer Control. 2022;29:10732748221089480. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 18.Pham MA, Benkortbi K, Kenfack B, Tincho Foguem E, Sormani J, Wisniak A, et al. Recruitment strategies to promote uptake of cervical cancer screening in the West Region of Cameroon. BMC Public Health. 2022;22(1):548. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 19.Rosser JI, Njoroge B, Huchko MJ. Changing knowledge, attitudes, and behaviors regarding cervical cancer screening: the effects of an educational intervention in rural Kenya. Patient Educ Couns. 2015;98(7):884–9. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 20.Tum SJ, Maree JE, Clarke M. Creating awareness and facilitating cervical and breast cancer screening uptake through the use of a Community Health Worker: a pilot intervention study. Eur J Cancer Care(Engl). 2013;22(1):107–16. [DOI] [PubMed] [Google Scholar]
  • 21.Ghahremani L, Harami ZK, Kaveh MH, Keshavarzi S. Investigation of the role of training health volunteers in promoting Pap smear test use among Iranian women based on the protection motivation theory. Asian Pac J Cancer Prev. 2016;17(3):1157–62. [PubMed] [Google Scholar]
  • 22.O’Brien MJ, Halbert CH, Bixby R, Pimentel S, Shea JA. Community health worker intervention to decrease cervical cancer disparities in Hispanic women. J Gen Intern Med. 2010;25(11):1186–92. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 23.Enebe JT. The awareness and uptake of cervical cancer screening among female nurses in Enugu, South-East, Nigeria. TIJPH. 2020;8(2):154–64. [Google Scholar]
  • 24.Ike EU, Nlemuwa GN, Gbadamosi IA, Ndikom CM. Awareness and utilisation of cervical cancer screening among mothers attending antenatal and postnatal clinics at a state hospital in Nigeria. EMJ. 2025 Repro Health. 2025. https://www.emjreviews.com/reproductive-health/article/awareness-and-utilisation-of-cervical-cancer-screening-among-mothers-attending-antenatal-and-postnatal-clinics-at-a-state-hospital-in-nigeria/. Assessed 2025 Apr 21.
  • 25.Datchoua Moukam AM, Embolo Owono MS, Kenfack B, Vassilakos P, Petignat P, Sormani J, et al. Cervical cancer screening: awareness is not enough. Understanding barriers to screening among women in West Cameroon—a qualitative study using focus groups. Reprod Health. 2021;18(1):147. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 26.Chan DNS, So WKW. Effectiveness of motivational interviewing in enhancing cancer screening uptake amongst average-risk individuals: A systematic review. Int J Nurs Stud. 2021;113:103786. [DOI] [PubMed] [Google Scholar]
  • 27.Kok MC, Dieleman M, Taegtmeyer M, Broerse JEW, Kane SS, Ormel H, et al. Which intervention design factors influence performance of community health workers in low- and middle-income countries? A systematic review. Health Policy Plan. 2015;30:1207–27. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 28.Gadsden T, Sujarwoto S, Purwaningtyas N, Maharani A, Tampubolon G, Oceandy D, et al. Understanding community health worker employment preferences in Malang district, Indonesia, using a discrete choice experiment. BMJ Glob Health. 2022;7(8):e008936. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 29.Hämmerli P, Moukam AD, Wisniak A, Sormani J, Vassilakos P, Kenfack B, et al. My motivation was to save: a qualitative study exploring factors influencing motivation of community healthcare workers in a cervical cancer screening program in Dschang, Cameroon. Reprod Health. 2022;19:133. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 30.Jede F, Brandt T, Gedefaw M, Wubneh SB, Abebe T, Teka B, et al. Home-based HPV self-sampling assisted by a cloud-based electronic data system: lessons learnt from a pilot community cervical cancer screening campaign in rural Ethiopia. Papillomavirus Res. 2020;9:100198. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 31.Nakalembe M, Makanga P, Kambugu A, Laker-Oketta M, Huchko M, Martin J. A public health approach to cervical cancer screening in Africa through community-based self-administered HPV testing and mobile treatment provision. 2019.medRxiv Assessed 2025 Apr 21. p. 2019.12.19.19015446. https://www.medrxiv.org/content/10.1101/2019.12.19.19015446v1. [DOI] [PMC free article] [PubMed]
  • 32.Moses E, Pedersen HN, Mitchell SM, Sekikubo M, Mwesigwa D, Singer J, et al. Uptake of community-based, self-collected HPV testing vs. visual inspection with acetic acid for cervical cancer screening in Kampala, Uganda: preliminary results of a randomised controlled trial. Trop Med Int Health. 2015;20(10):1355–67. [DOI] [PubMed] [Google Scholar]
  • 33.Arrossi S, Thouyaret L, Herrero R, Campanera A, Magdaleno A, Cuberli M, et al. Effect of self-collection of HPV DNA offered by community health workers at home visits on uptake of screening for cervical cancer (the EMA study): a population-based cluster-randomised trial. Lancet Glob Health. 2015;3(2):e85–94. [DOI] [PubMed] [Google Scholar]
  • 34.Wong CL, Choi KC, Chen J, Law BMH, Chan DNS, So WKW. A community health worker–led multicomponent program to promote cervical cancer screening in South Asian women: A cluster RCT. Am J Prev Med. 2021;61:136–45. [DOI] [PubMed] [Google Scholar]
  • 35.Chinkhumba J, Low D, Ziphondo E, Msowoya L, Rao D, Smith JS, et al. Assessing community health workers’ time allocation for a cervical cancer screening and treatment intervention in Malawi: a time and motion study. BMC Health Serv Res. 2022;22:1196. [DOI] [PMC free article] [PubMed] [Google Scholar]

Associated Data

This section collects any data citations, data availability statements, or supplementary materials included in this article.

Data Availability Statement

Data is provided within the manuscript or supplementary information files.


Articles from BMC Public Health are provided here courtesy of BMC

RESOURCES