Skip to main content
NCBI home page
Immunology logoLink to Immunology
. 1997 May;91(1):109–113. doi: 10.1046/j.1365-2567.1997.00201.x

A role for interferon-gamma and transforming growth factor-beta in erythroid cell-mediated regulation of nitric oxide production in macrophages.

G V Seledtsova 1, V I Seledtsov 1, V Y Taraban 1, D M Samarin 1, V A Kozlov 1
PMCID: PMC1364042  PMID: 9203973

Abstract

Interferon-gamma (IFN-gamma) and transforming growth factor-beta (TGF-beta) are known to be a potent inducer and inhibitor for macrophage (Mo) activation process, respectively. In the present study we established that the nucleated erythroid cells (NEC) separated from the spleens of adult (CBA x C57BL/6)F1 (CBF, H-2k/H-2d) mice following phenylhydrazine treatment are potentially capable of inducing nitric oxide (NO) production in thioglycollate broth-elicited peritoneal macrophages (Mo). The stimulating effect of both NEC and their culture supernatant on NO secretion by Mo was most apparent in the presence of bacterial lipopolysaccharide (LPS) and neutralizing antibodies (Abs) to TGF-beta and was largely reversed by the addition to the culture of neutralizing Abs to IFN-gamma. Collectively these results suggest that NEC, through production of IFN-gamma and TGF-beta, may exert a regulatory influence on development and functionality of cells pertaining to monocyte (Mc)/Mo lineage.

Full text

PDF
109

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Adams L. B., Franzblau S. G., Vavrin Z., Hibbs J. B., Jr, Krahenbuhl J. L. L-arginine-dependent macrophage effector functions inhibit metabolic activity of Mycobacterium leprae. J Immunol. 1991 Sep 1;147(5):1642–1646. [PubMed] [Google Scholar]
  2. Bogdan C., Vodovotz Y., Nathan C. Macrophage deactivation by interleukin 10. J Exp Med. 1991 Dec 1;174(6):1549–1555. doi: 10.1084/jem.174.6.1549. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Boutard V., Havouis R., Fouqueray B., Philippe C., Moulinoux J. P., Baud L. Transforming growth factor-beta stimulates arginase activity in macrophages. Implications for the regulation of macrophage cytotoxicity. J Immunol. 1995 Aug 15;155(4):2077–2084. [PubMed] [Google Scholar]
  4. Deng W., Thiel B., Tannenbaum C. S., Hamilton T. A., Stuehr D. J. Synergistic cooperation between T cell lymphokines for induction of the nitric oxide synthase gene in murine peritoneal macrophages. J Immunol. 1993 Jul 1;151(1):322–329. [PubMed] [Google Scholar]
  5. Ding A. H., Nathan C. F., Stuehr D. J. Release of reactive nitrogen intermediates and reactive oxygen intermediates from mouse peritoneal macrophages. Comparison of activating cytokines and evidence for independent production. J Immunol. 1988 Oct 1;141(7):2407–2412. [PubMed] [Google Scholar]
  6. Ding A., Nathan C. F., Graycar J., Derynck R., Stuehr D. J., Srimal S. Macrophage deactivating factor and transforming growth factors-beta 1 -beta 2 and -beta 3 inhibit induction of macrophage nitrogen oxide synthesis by IFN-gamma. J Immunol. 1990 Aug 1;145(3):940–944. [PubMed] [Google Scholar]
  7. Doyle A. G., Herbein G., Montaner L. J., Minty A. J., Caput D., Ferrara P., Gordon S. Interleukin-13 alters the activation state of murine macrophages in vitro: comparison with interleukin-4 and interferon-gamma. Eur J Immunol. 1994 Jun;24(6):1441–1445. doi: 10.1002/eji.1830240630. [DOI] [PubMed] [Google Scholar]
  8. Glimcher L. H., Kara C. J. Sequences and factors: a guide to MHC class-II transcription. Annu Rev Immunol. 1992;10:13–49. doi: 10.1146/annurev.iy.10.040192.000305. [DOI] [PubMed] [Google Scholar]
  9. Gollnick S. O., Cheng H. L., Grande C. C., Thompson D., Tomasi T. B. Effects of transforming growth factor-beta on bone marrow macrophage Ia expression induced by cytokines. J Interferon Cytokine Res. 1995 May;15(5):485–491. doi: 10.1089/jir.1995.15.485. [DOI] [PubMed] [Google Scholar]
  10. Hanspal M., Hanspal J. S. The association of erythroblasts with macrophages promotes erythroid proliferation and maturation: a 30-kD heparin-binding protein is involved in this contact. Blood. 1994 Nov 15;84(10):3494–3504. [PubMed] [Google Scholar]
  11. Hibbs J. B., Jr, Taintor R. R., Vavrin Z. Macrophage cytotoxicity: role for L-arginine deiminase and imino nitrogen oxidation to nitrite. Science. 1987 Jan 23;235(4787):473–476. doi: 10.1126/science.2432665. [DOI] [PubMed] [Google Scholar]
  12. Higuchi M., Higashi N., Taki H., Osawa T. Cytolytic mechanisms of activated macrophages. Tumor necrosis factor and L-arginine-dependent mechanisms act synergistically as the major cytolytic mechanisms of activated macrophages. J Immunol. 1990 Feb 15;144(4):1425–1431. [PubMed] [Google Scholar]
  13. Jadus M. R., Parkman R. The selective growth of murine newborn-derived suppressor cells and their probable mode of action. J Immunol. 1986 Feb 1;136(3):783–792. [PubMed] [Google Scholar]
  14. James S. L., Glaven J. Macrophage cytotoxicity against schistosomula of Schistosoma mansoni involves arginine-dependent production of reactive nitrogen intermediates. J Immunol. 1989 Dec 15;143(12):4208–4212. [PubMed] [Google Scholar]
  15. Johnson C. S., Pourbohloul S. C., Furmanski P. Negative regulators of in vivo erythropoiesis: interaction of IL-1 alpha and TNF-alpha and the lack of a strict requirement for T or NK cells for their activity. Exp Hematol. 1991 Feb;19(2):101–105. [PubMed] [Google Scholar]
  16. Langrehr J. M., Hoffman R. A., Lancaster J. R., Jr, Simmons R. L. Nitric oxide--a new endogenous immunomodulator. Transplantation. 1993 Jun;55(6):1205–1212. doi: 10.1097/00007890-199306000-00001. [DOI] [PubMed] [Google Scholar]
  17. Liew F. Y., Li Y., Severn A., Millott S., Schmidt J., Salter M., Moncada S. A possible novel pathway of regulation by murine T helper type-2 (Th2) cells of a Th1 cell activity via the modulation of the induction of nitric oxide synthase on macrophages. Eur J Immunol. 1991 Oct;21(10):2489–2494. doi: 10.1002/eji.1830211027. [DOI] [PubMed] [Google Scholar]
  18. Mitasov A. V., Tsyrlova I. G., Kiselev S. V., Kozlov V. V. Species-nonspecific action of soluble immunosuppressive factor produced by murine immature erythroid cells. Ann N Y Acad Sci. 1991;628:399–409. doi: 10.1111/j.1749-6632.1991.tb17276.x. [DOI] [PubMed] [Google Scholar]
  19. Moore S. C., Shaw M. A., Soderberg L. S. Transforming growth factor-beta is the major mediator of natural suppressor cells derived from normal bone marrow. J Leukoc Biol. 1992 Dec;52(6):596–601. doi: 10.1002/jlb.52.6.596. [DOI] [PubMed] [Google Scholar]
  20. Mosmann T. R., Sad S. The expanding universe of T-cell subsets: Th1, Th2 and more. Immunol Today. 1996 Mar;17(3):138–146. doi: 10.1016/0167-5699(96)80606-2. [DOI] [PubMed] [Google Scholar]
  21. Nathan C. Nitric oxide as a secretory product of mammalian cells. FASEB J. 1992 Sep;6(12):3051–3064. [PubMed] [Google Scholar]
  22. Ohls R. K., Li Y., Trautman M. S., Christensen R. D. Erythropoietin production by macrophages from preterm infants: implications regarding the cause of the anemia of prematurity. Pediatr Res. 1994 Feb;35(2):169–170. doi: 10.1203/00006450-199402000-00008. [DOI] [PubMed] [Google Scholar]
  23. Rosenfeld C. S. Transforming growth factor-beta 1 augments macrophage-colony stimulating factor activity on human marrow. Stem Cells. 1994 Sep;12(5):527–532. doi: 10.1002/stem.5530120509. [DOI] [PubMed] [Google Scholar]
  24. Seledtsov V. I., Avdeev I. V., Morenkov A. V., Seledtsova G. V., Kozlov V. A. Antiproliferative effect of bone marrow cells on leukemic cells. Immunobiology. 1995 Feb;192(3-4):205–217. doi: 10.1016/S0171-2985(11)80098-7. [DOI] [PubMed] [Google Scholar]
  25. Sennikov S. V., Eremina L. V., Samarin D. M., Avdeev I. V., Kozlov V. A. Cytokine gene expression in erythroid cells. Eur Cytokine Netw. 1996 Dec;7(4):771–774. [PubMed] [Google Scholar]
  26. Thiele D. L., Lipsky P. E. Regulation of cellular function by products of lysosomal enzyme activity: elimination of human natural killer cells by a dipeptide methyl ester generated from L-leucine methyl ester by monocytes or polymorphonuclear leukocytes. Proc Natl Acad Sci U S A. 1985 Apr;82(8):2468–2472. doi: 10.1073/pnas.82.8.2468. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Immunology are provided here courtesy of British Society for Immunology

RESOURCES