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. 1997 Dec;92(4):487–493. doi: 10.1046/j.1365-2567.1997.00369.x

The defective antigen-presenting activity of murine fetal macrophage cell lines.

H Khalili 1, R Deshpande 1, M Y Chang 1
PMCID: PMC1364154  PMID: 9497490

Abstract

We have previously reported that placental macrophages of fetal origin have a decreased ability to present antigen. To clarify the underlying mechanism for this deficiency, we have generated primary fetal macrophage cell lines. Our data show that despite their defective antigen-presenting ability, fetal macrophages do express all known accessory molecules, intracellular adhesion molecule-1, B7 and major histocompatibility complex class II molecules. However, fetal macrophages do not express detectable invariant chain mRNA which is known to have a major role in the class II-associated antigen-processing pathway. Since fetal macrophages can neither present antigenic peptides nor superantigen, the diminished invariant chain expression alone cannot account for the impaired antigen-presenting function of fetal macrophages.

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Selected References

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