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. 1998 Jul;94(3):331–339. doi: 10.1046/j.1365-2567.1998.00519.x

Staphylococcal enterotoxin B-induced T-cell anergy is mediated by regulatory T cells.

Z Q Wang 1, T Orlikowsky 1, A Dudhane 1, V Trejo 1, G E Dannecker 1, B Pernis 1, M K Hoffmann 1
PMCID: PMC1364250  PMID: 9767414

Abstract

Naive T cells mount a vigorous proliferative response to superantigen (SAg) stimulation in vivo. The proliferative response is followed by a partial deletion of responder T cells. Part of the deletion process has recently been attributed to the action of regulatory cytotoxic T cells that recognize major histocompatibility complex (MHC) class I-associated antigen receptor determinants on the target cell surface. Responder T cells that survived the SAg response were found to be incapable of generating a secondary proliferative response to a SAg challenge. We show here that this 'anergy' is enforced by CD8-positive regulatory suppressive T cells. These regulatory cells inhibit cell division of preactivated T cells but not the Sag response of naive T cells. Regulatory T cells are not generated in the presence of cyclosporin A and, once activated, become inactivated or deleted when restimulated in the presence of this immunosuppressive drug.

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Selected References

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