Skip to main content
NCBI home page
Immunology logoLink to Immunology
. 1998 Jul;94(3):403–409. doi: 10.1046/j.1365-2567.1998.00531.x

Increased serum IgG1 levels and reduced numbers of B-1 B cells in DBA/2J mice.

K Tocce 1, G Masters 1, C Rago 1, L Prior 1, K Suppiah 1, T Glysing-Jensen 1, S Leary 1, J Riggs 1
PMCID: PMC1364260  PMID: 9767424

Abstract

B-cell heterogeneity studies have historically focused upon BALB/c mice and their derivatives. In contrast, the B cells of DBA/2J mice, a prototype strain for the study of the endogenous minor lymphocyte stimulatory (Mls) viral superantigen Mls-1a, have not been extensively investigated. DBA/2J B cells, by functioning as Mls-1a antigen-presenting cells, influence their own differentiation and diversity by inducing the proliferation and differentiation of specific CD4 T-cell subsets. In this report, the B cells of DBA/2J and BALB/c mice were compared for their ability to restore B-cell function in severe combined immunodeficient (SCID) recipients. Although spleen and bone marrow cells from these strains exhibited similar restoration of serum IgM production, the transfer of DBA/2J B cells into SCID mice led to greater IgG1 production. The peritoneal cells of DBA/2J mice consisted of a lower percentage of B-1 B cells and were less capable of restoring B-cell function after transfer into SCID recipients. These differences are discussed with respect to the possible role of viral superantigens in influencing B-lymphocyte diversity.

Full text

PDF
403

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Acha-Orbea H., MacDonald H. R. Superantigens of mouse mammary tumor virus. Annu Rev Immunol. 1995;13:459–486. doi: 10.1146/annurev.iy.13.040195.002331. [DOI] [PubMed] [Google Scholar]
  2. Ardavín C., Waanders G., Ferrero I., Anjuère F., Acha-Orbea H., MacDonald H. R. Expression and presentation of endogenous mouse mammary tumor virus superantigens by thymic and splenic dendritic cells and B cells. J Immunol. 1996 Oct 1;157(7):2789–2794. [PubMed] [Google Scholar]
  3. Bandeira A., Mengel J., Burlen-Defranoux O., Coutinho A. Proliferative T cell anergy to MIs-1a does not correlate with in vivo tolerance. Int Immunol. 1991 Sep;3(9):923–931. doi: 10.1093/intimm/3.9.923. [DOI] [PubMed] [Google Scholar]
  4. Bosma M. J., Carroll A. M. The SCID mouse mutant: definition, characterization, and potential uses. Annu Rev Immunol. 1991;9:323–350. doi: 10.1146/annurev.iy.09.040191.001543. [DOI] [PubMed] [Google Scholar]
  5. Choi Y., Kappler J. W., Marrack P. A superantigen encoded in the open reading frame of the 3' long terminal repeat of mouse mammary tumour virus. Nature. 1991 Mar 21;350(6315):203–207. doi: 10.1038/350203a0. [DOI] [PubMed] [Google Scholar]
  6. Coffman R. L., Seymour B. W., Lebman D. A., Hiraki D. D., Christiansen J. A., Shrader B., Cherwinski H. M., Savelkoul H. F., Finkelman F. D., Bond M. W. The role of helper T cell products in mouse B cell differentiation and isotype regulation. Immunol Rev. 1988 Feb;102:5–28. doi: 10.1111/j.1600-065x.1988.tb00739.x. [DOI] [PubMed] [Google Scholar]
  7. Festenstein H. Immunogenetic and biological aspects of in vitro lymphocyte allotransformation (MLR) in the mouse. Transplant Rev. 1973;15:62–88. doi: 10.1111/j.1600-065x.1973.tb00111.x. [DOI] [PubMed] [Google Scholar]
  8. Förster I., Rajewsky K. Expansion and functional activity of Ly-1+ B cells upon transfer of peritoneal cells into allotype-congenic, newborn mice. Eur J Immunol. 1987 Apr;17(4):521–528. doi: 10.1002/eji.1830170414. [DOI] [PubMed] [Google Scholar]
  9. Gollob K. J., Nagelkerken L., Coffman R. L. Endogenous retroviral superantigen presentation by B cells induces the development of type 1 CD4+ T helper lymphocytes. Eur J Immunol. 1993 Oct;23(10):2565–2571. doi: 10.1002/eji.1830231028. [DOI] [PubMed] [Google Scholar]
  10. Hayakawa K., Hardy R. R., Parks D. R., Herzenberg L. A. The "Ly-1 B" cell subpopulation in normal immunodefective, and autoimmune mice. J Exp Med. 1983 Jan 1;157(1):202–218. doi: 10.1084/jem.157.1.202. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Herrmann T., Waanders G. A., Chvatchko Y., MacDonald H. R. The viral superantigen Mls-1a induces interferon-gamma secretion by specifically primed CD8+ cells but fails to trigger cytotoxicity. Eur J Immunol. 1992 Nov;22(11):2789–2793. doi: 10.1002/eji.1830221106. [DOI] [PubMed] [Google Scholar]
  12. Herzenberg L. A., Stall A. M., Lalor P. A., Sidman C., Moore W. A., Parks D. R., Herzenberg L. A. The Ly-1 B cell lineage. Immunol Rev. 1986 Oct;93:81–102. doi: 10.1111/j.1600-065x.1986.tb01503.x. [DOI] [PubMed] [Google Scholar]
  13. Hitoshi Y., Mita S., Tominaga A., Kikuchi Y., Sonoda E., Takatsu K., Watanabe Y. Interferon-gamma inhibits the proliferation but not the differentiation of murine B cells in response to IL-5. Int Immunol. 1989;1(2):185–190. doi: 10.1093/intimm/1.2.185. [DOI] [PubMed] [Google Scholar]
  14. Huang C. A., Henry C., Iacomini J., Imanishi-Kari T., Wortis H. H. Adult bone marrow contains precursors for CD5+ B cells. Eur J Immunol. 1996 Oct;26(10):2537–2540. doi: 10.1002/eji.1830261039. [DOI] [PubMed] [Google Scholar]
  15. Kantor A. B. The development and repertoire of B-1 cells (CD5 B cells). Immunol Today. 1991 Nov;12(11):389–391. doi: 10.1016/0167-5699(91)90136-H. [DOI] [PubMed] [Google Scholar]
  16. Luther S. A., Acha-Orbea H. Immune response to mouse mammary tumour virus. Curr Opin Immunol. 1996 Aug;8(4):498–502. doi: 10.1016/s0952-7915(96)80037-9. [DOI] [PubMed] [Google Scholar]
  17. MacDonald H. R., Schneider R., Lees R. K., Howe R. C., Acha-Orbea H., Festenstein H., Zinkernagel R. M., Hengartner H. T-cell receptor V beta use predicts reactivity and tolerance to Mlsa-encoded antigens. Nature. 1988 Mar 3;332(6159):40–45. doi: 10.1038/332040a0. [DOI] [PubMed] [Google Scholar]
  18. Modlin C. S., Muruve N. A., Stanko D., Caulfield M. J., Fairchild R. L. Recipient polyclonal B cell activation and immunoglobulin production induced by priming with a retroviral superantigen. Cell Immunol. 1996 May 1;169(2):252–263. doi: 10.1006/cimm.1996.0116. [DOI] [PubMed] [Google Scholar]
  19. Mosier D. E. Are xid B lymphocytes representative of any normal B cell population. A commentary. J Mol Cell Immunol. 1985;2(2):70–70. [PubMed] [Google Scholar]
  20. Prior L., Pierson S., Woodland R. T., Riggs J. Rapid restoration of B-cell function in XID mice by intravenous transfer of peritoneal cavity B cells. Immunology. 1994 Oct;83(2):180–183. [PMC free article] [PubMed] [Google Scholar]
  21. Riggs J. E., Maurio F. P., Prior L. G., Sirken G. R., Hobbs M. V. The autologous mixed lymphocyte response: delayed T cell tolerance to B cells in XID mice. Cell Immunol. 1994 Sep;157(2):542–548. doi: 10.1006/cimm.1994.1248. [DOI] [PubMed] [Google Scholar]
  22. Riggs J. E., Stowers R. S., Mosier D. E. Adoptive transfer of neonatal T lymphocytes rescues immunoglobulin production in mice with severe combined immune deficiency. J Exp Med. 1991 Jan 1;173(1):265–268. doi: 10.1084/jem.173.1.265. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. Riggs J. E., Stowers R. S., Mosier D. E. The immunoglobulin allotype contributed by peritoneal cavity B cells dominates in SCID mice reconstituted with allotype-disparate mixtures of splenic and peritoneal cavity B cells. J Exp Med. 1990 Aug 1;172(2):475–485. doi: 10.1084/jem.172.2.475. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. Riggs J., Stowers R. Ability of spleen, peritoneal cavity, and lymph node B cells to reconstitute serum immunoglobulin in SCID mice. Immunology. 1996 May;88(1):20–27. doi: 10.1046/j.1365-2567.1996.d01-636.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  25. Scher I. CBA/N immune defective mice; evidence for the failure of a B cell subpopulation to be expressed. Immunol Rev. 1982;64:117–136. doi: 10.1111/j.1600-065x.1982.tb00421.x. [DOI] [PubMed] [Google Scholar]
  26. Speiser D. E., Schneider R., Hengartner H., MacDonald H. R., Zinkernagel R. M. Clonal deletion of self-reactive T cells in irradiation bone marrow chimeras and neonatally tolerant mice. Evidence for intercellular transfer of Mlsa. J Exp Med. 1989 Aug 1;170(2):595–600. doi: 10.1084/jem.170.2.595. [DOI] [PMC free article] [PubMed] [Google Scholar]
  27. Vogel L. A., Lester T. L., Van Cleave V. H., Metzger D. W. Inhibition of murine B1 lymphocytes by interleukin-12. Eur J Immunol. 1996 Jan;26(1):219–223. doi: 10.1002/eji.1830260134. [DOI] [PubMed] [Google Scholar]

Articles from Immunology are provided here courtesy of British Society for Immunology

RESOURCES