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. 1993 Jul;36(1):39–43. doi: 10.1111/j.1365-2125.1993.tb05889.x

The basis of the histamine assay in human skin: II. Wheal formation.

C Carey 1, M Clark 1, J A Lopez-Gil 1, D W Vere 1
PMCID: PMC1364552  PMID: 8373711

Abstract

1. Subepidermal injection of histamine solutions in isotonic saline in four subjects evoked whealing after a mean delay of 2.6 min, this estimate being derived by regression modelling. 2. Wheal growth was better modelled by the logarithm of time than by time, suggesting that wheal size depends upon assisted diffusion of histamine in the dermis. 3. Wheal growth was piecemeal, not continuous, consistent with the successive involvement of neighbouring vascular territories. 4. Wheal growth was completed by 9 min after injection.

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Selected References

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  1. Altura B. M. Reticuloendothelial system function and histamine release in shock and trauma: relationship to microcirculation. Klin Wochenschr. 1982 Sep 1;60(17):882–890. doi: 10.1007/BF01716944. [DOI] [PubMed] [Google Scholar]
  2. BIRMINGHAM A. T. The log dose-response relationship for intradermal old tuberculin in tuberculous patients. Tubercle. 1962 Sep;43:287–291. doi: 10.1016/s0041-3879(62)80068-3. [DOI] [PubMed] [Google Scholar]
  3. Barnes P. J., Brown M. J., Dollery C. T., Fuller R. W., Heavey D. J., Ind P. W. Histamine is released from skin by substance P but does not act as the final vasodilator in the axon reflex. Br J Pharmacol. 1986 Aug;88(4):741–745. doi: 10.1111/j.1476-5381.1986.tb16246.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Byrom H., Clark M., White V., Vere D. W. The basis of the histamine assay in skin. Br J Clin Pharmacol. 1991 Sep;32(3):367–370. doi: 10.1111/j.1365-2125.1991.tb03913.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. McNamee J. E., Grodins F. S. Effect of histamine on microvasculature of isolated dog gracilis muscle. Am J Physiol. 1975 Jul;229(1):119–125. doi: 10.1152/ajplegacy.1975.229.1.119. [DOI] [PubMed] [Google Scholar]
  6. Northover A. M., Northover B. J. The effect of vaso-active substances on rat mesenteric blood vessels. J Pathol. 1970 Jun;101(2):99–108. doi: 10.1002/path.1711010205. [DOI] [PubMed] [Google Scholar]
  7. Northover A. M., Northover B. J. The effects of histamine, 5-hydroxytryptamine and bradykinin on rat mesenteric blood vessels. J Pathol. 1969 Aug;98(4):265–275. doi: 10.1002/path.1710980406. [DOI] [PubMed] [Google Scholar]
  8. Owen D. A., Harvey C. A., Boyce M. J. Effects of histamine on the circulatory system. Klin Wochenschr. 1982 Sep 1;60(17):972–977. doi: 10.1007/BF01716957. [DOI] [PubMed] [Google Scholar]
  9. ROWLEY D. A. VENOUS CONSTRICTION AS THE CAUSE OF INCREASED VASCULAR PERMEABILITY PRODUCED BY 5-HYDROXYTRYPTAMINE, HISTAMINE, BRADYKININ AND 48/80 IN THE RAT. Br J Exp Pathol. 1964 Feb;45:56–67. [PMC free article] [PubMed] [Google Scholar]

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