Abstract
A possible interaction between tolbutamide and ketoconazole was studied in seven healthy volunteers. Treatment for 1 week with 200 mg oral ketoconazole increased the elimination half-life (from mean +/- s.d. 3.7 +/- 0.4 to 12.3 +/- 1.9 h) and AUC(0.12 h) of tolbutamide (from 309 +/- 27 to 546 +/- 20 micrograms ml-1 h) by 25 +/- 64 and 66 +/- 15%, respectively. The percentage blood glucose reduction was also increased when tolbutamide and ketoconazole were coadministered.
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Selected References
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- Back D. J., Tjia J. F., Karbwang J., Colbert J. In vitro inhibition studies of tolbutamide hydroxylase activity of human liver microsomes by azoles, sulphonamides and quinolines. Br J Clin Pharmacol. 1988 Jul;26(1):23–29. doi: 10.1111/j.1365-2125.1988.tb03359.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Matin S. B., Rowland M. Determination of tolbutamide and chlorpropamide in biological fluids. J Pharm Pharmacol. 1973 Feb;25(2):186–188. doi: 10.1111/j.2042-7158.1973.tb10620.x. [DOI] [PubMed] [Google Scholar]