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. 1994 Oct;38(4):369–372. doi: 10.1111/j.1365-2125.1994.tb04368.x

Pharmacokinetics and effects on intracranial pressure of sufentanil in head trauma patients.

J Scholz 1, H Bause 1, M Schulz 1, U Klotz 1, D R Krishna 1, S Pohl 1, J Schulte am Esch 1
PMCID: PMC1364782  PMID: 7833228

Abstract

Ten patients with head trauma received an intravenous bolus of sufentanil (2 micrograms kg-1) followed at 30 min by infusion of sufentanil (median 150 micrograms h-1) and midazolam (median 9.0 mg h-1) over 48 h. Median (range) values of pharmacokinetic parameters for sufentanil were: t1/2,z = 16 (7-49) h; CL = 1215 (519-2550) ml min-1; CLR = 7 (2-38) ml min-1; Vss = 10.0 (6.8-24.2) 1 kg-1. Decreases in intracranial pressure (ICP) (from 16.1 +/- 1.7 to 10.8 +/- 1.3 mm Hg; P < 0.05) and mean arterial blood pressure (MAP) (from 85.5 +/- 3.9 to 80.2 +/- 4.9 mm Hg; P < 0.05) were observed within 15 min of the bolus injection of sufentanil and remained unchanged thereafter. Thus, cerebral perfusion pressure (CPP = MAP-ICP) was stable.

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Selected References

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  1. Bovill J. G., Sebel P. S., Blackburn C. L., Oei-Lim V., Heykants J. J. The pharmacokinetics of sufentanil in surgical patients. Anesthesiology. 1984 Nov;61(5):502–506. doi: 10.1097/00000542-198411000-00004. [DOI] [PubMed] [Google Scholar]
  2. Clotz M. A., Nahata M. C. Clinical uses of fentanyl, sufentanil, and alfentanil. Clin Pharm. 1991 Aug;10(8):581–593. [PubMed] [Google Scholar]
  3. Davis P. J., Cook D. R., Stiller R. L., Davin-Robinson K. A. Pharmacodynamics and pharmacokinetics of high-dose sufentanil in infants and children undergoing cardiac surgery. Anesth Analg. 1987 Mar;66(3):203–208. [PubMed] [Google Scholar]
  4. Davis P. J., Stiller R. L., Cook D. R., Brandom B. W., Davin-Robinson K. A. Pharmacokinetics of sufentanil in adolescent patients with chronic renal failure. Anesth Analg. 1988 Mar;67(3):268–271. [PubMed] [Google Scholar]
  5. Fyman P. N., Reynolds J. R., Moser F., Avitable M., Casthely P. A., Butt K. Pharmacokinetics of sufentanil in patients undergoing renal transplantation. Can J Anaesth. 1988 May;35(3 ):312–315. doi: 10.1007/BF03010638. [DOI] [PubMed] [Google Scholar]
  6. Garzone P. D., Kroboth P. D. Pharmacokinetics of the newer benzodiazepines. Clin Pharmacokinet. 1989 Jun;16(6):337–364. doi: 10.2165/00003088-198916060-00002. [DOI] [PubMed] [Google Scholar]
  7. Greeley W. J., de Bruijn N. P., Davis D. P. Sufentanil pharmacokinetics in pediatric cardiovascular patients. Anesth Analg. 1987 Nov;66(11):1067–1072. [PubMed] [Google Scholar]
  8. Guay J., Gaudreault P., Tang A., Goulet B., Varin F. Pharmacokinetics of sufentanil in normal children. Can J Anaesth. 1992 Jan;39(1):14–20. doi: 10.1007/BF03008666. [DOI] [PubMed] [Google Scholar]
  9. Hudson R. J., Bergstrom R. G., Thomson I. R., Sabourin M. A., Rosenbloom M., Strunin L. Pharmacokinetics of sufentanil in patients undergoing abdominal aortic surgery. Anesthesiology. 1989 Mar;70(3):426–431. doi: 10.1097/00000542-198903000-00011. [DOI] [PubMed] [Google Scholar]
  10. Keykhah M. M., Smith D. S., Carlsson C., Safo Y., Englebach I., Harp J. R. Influence of sufentanil on cerebral metabolism and circulation in the rat. Anesthesiology. 1985 Sep;63(3):274–277. doi: 10.1097/00000542-198509000-00006. [DOI] [PubMed] [Google Scholar]
  11. Klotz U., Reimann I. W. Chronopharmacokinetic study with prolonged infusion of midazolam. Clin Pharmacokinet. 1984 Sep-Oct;9(5):469–474. doi: 10.2165/00003088-198409050-00006. [DOI] [PubMed] [Google Scholar]
  12. Mandema J. W., Tuk B., van Steveninck A. L., Breimer D. D., Cohen A. F., Danhof M. Pharmacokinetic-pharmacodynamic modeling of the central nervous system effects of midazolam and its main metabolite alpha-hydroxymidazolam in healthy volunteers. Clin Pharmacol Ther. 1992 Jun;51(6):715–728. doi: 10.1038/clpt.1992.84. [DOI] [PubMed] [Google Scholar]
  13. Marx W., Shah N., Long C., Arbit E., Galicich J., Mascott C., Mallya K., Bedford R. Sufentanil, alfentanil, and fentanyl: impact on cerebrospinal fluid pressure in patients with brain tumors. J Neurosurg Anesthesiol. 1989 Mar;1(1):3–7. [PubMed] [Google Scholar]
  14. Matteo R. S., Schwartz A. E., Ornstein E., Young W. L., Chang W. J. Pharmacokinetics of sufentanil in the elderly surgical patient. Can J Anaesth. 1990 Nov;37(8):852–856. doi: 10.1007/BF03006620. [DOI] [PubMed] [Google Scholar]
  15. Mayer N., Weinstabl C., Podreka I., Spiss C. K. Sufentanil does not increase cerebral blood flow in healthy human volunteers. Anesthesiology. 1990 Aug;73(2):240–243. doi: 10.1097/00000542-199008000-00009. [DOI] [PubMed] [Google Scholar]
  16. Michiels M., Hendriks R., Heykants J. Radioimmunoassay of the new opiate analgesics alfentanil and sufentanil. Preliminary pharmacokinetic profile in man. J Pharm Pharmacol. 1983 Feb;35(2):86–93. doi: 10.1111/j.2042-7158.1983.tb04275.x. [DOI] [PubMed] [Google Scholar]
  17. Milde L. N., Milde J. H., Gallagher W. J. Effects of sufentanil on cerebral circulation and metabolism in dogs. Anesth Analg. 1990 Feb;70(2):138–146. doi: 10.1213/00000539-199002000-00002. [DOI] [PubMed] [Google Scholar]
  18. Monk J. P., Beresford R., Ward A. Sufentanil. A review of its pharmacological properties and therapeutic use. Drugs. 1988 Sep;36(3):286–313. doi: 10.2165/00003495-198836030-00003. [DOI] [PubMed] [Google Scholar]
  19. Sebel P. S., Bovil J. G. Cardiovascular effects of sufentanil anesthesia. Anesth Analg. 1982 Feb;61(2):115–119. [PubMed] [Google Scholar]
  20. Sperry R. J., Bailey P. L., Reichman M. V., Peterson J. C., Petersen P. B., Pace N. L. Fentanyl and sufentanil increase intracranial pressure in head trauma patients. Anesthesiology. 1992 Sep;77(3):416–420. doi: 10.1097/00000542-199209000-00002. [DOI] [PubMed] [Google Scholar]
  21. Weinstabl C., Mayer N., Richling B., Czech T., Spiss C. K. Effect of sufentanil on intracranial pressure in neurosurgical patients. Anaesthesia. 1991 Oct;46(10):837–840. doi: 10.1111/j.1365-2044.1991.tb09596.x. [DOI] [PubMed] [Google Scholar]
  22. Werner C., Hoffman W. E., Baughman V. L., Albrecht R. F., Schulte J. Effects of sufentanil on cerebral blood flow, cerebral blood flow velocity, and metabolism in dogs. Anesth Analg. 1991 Feb;72(2):177–181. doi: 10.1213/00000539-199102000-00006. [DOI] [PubMed] [Google Scholar]
  23. de Lange S., Boscoe M. J., Stanley T. H., Pace N. Comparison of sufentanil--O2 and fentanyl--02 for coronary artery surgery. Anesthesiology. 1982 Feb;56(2):112–118. doi: 10.1097/00000542-198202000-00006. [DOI] [PubMed] [Google Scholar]

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