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. 1994 May;37(5):457–459. doi: 10.1111/j.1365-2125.1994.tb05714.x

Trilinolein improves erythrocyte deformability during cardiopulmonary bypass.

S K Tsai 1, P Chan 1, T Y Lee 1, J M Yung 1, C Y Hong 1
PMCID: PMC1364902  PMID: 8054252

Abstract

The in vitro effect of trilinolein, a triglyceride with linoleic acid as the major fatty acid residue in the esterified positions of glycerol, on erythrocyte deformability was studied in blood samples collected from 12 patients before and after cardiopulmonary bypass (CPB). Erythrocyte deformability was measured with a filtration method and expressed as red cell filtration rate (RFR). RFR was reduced after CPB and the reduction was time dependent. Trilinolein at a concentration of 10(-7) M significantly reversed the CPB-induced reduction of RFR when it was mixed with blood samples collected 30, 60 and 90 min from the start of CPB. This study confirmed the effect of CPB on erythrocyte deformability and showed that this damage could be significantly improved by mixing blood with trilinolein.

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Selected References

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  1. BERNSTEIN E. F., CASTANEDA A. R., BLACKSHEAR P. L., VARCO R. L. PROLONGED MECHANICAL CIRCULATORY SUPPORT: ANALYSIS OF CERTAIN PHYSICAL AND PHYSIOLOGIC CONSIDERATIONS. Surgery. 1965 Jan;57:103–122. [PubMed] [Google Scholar]
  2. Bayer R., Plewa S., Borcescu E., Claus W. Filterability of human erythrocytes--drug induced prevention of aging in vitro. Arzneimittelforschung. 1988 Dec;38(12):1765–1767. [PubMed] [Google Scholar]
  3. Bernstein E. F., Blackshear P. L., Jr, Keller K. H. Factors influencing erythrocyte destruction in artificial organs. Am J Surg. 1967 Jul;114(1):126–138. doi: 10.1016/0002-9610(67)90047-5. [DOI] [PubMed] [Google Scholar]
  4. Ekeström S., Koul B. L., Sonnenfeld T. Decreased red cell deformability following open-heart surgery. Scand J Thorac Cardiovasc Surg. 1983;17(1):41–44. doi: 10.3109/14017438309102376. [DOI] [PubMed] [Google Scholar]
  5. Elgsaeter A., Stokke B. T., Mikkelsen A., Branton D. The molecular basis of erythrocyte shape. Science. 1986 Dec 5;234(4781):1217–1223. doi: 10.1126/science.3775380. [DOI] [PubMed] [Google Scholar]
  6. Gini E. K., Sonnet J. Use of piracetam improves sickle cell deformability in vitro and in vivo. J Clin Pathol. 1987 Jan;40(1):99–102. doi: 10.1136/jcp.40.1.99. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Hirayama T., Roberts D. G., Allers M., Belboul A., al-Khaja N., William-Olsson G. Association between pulmonary dysfunction and reduced red cell deformability following cardiopulmonary bypass. Scand J Thorac Cardiovasc Surg. 1988;22(2):175–177. doi: 10.3109/14017438809105953. [DOI] [PubMed] [Google Scholar]
  8. Hirayama T., Yamaguchi H., Allers M., Roberts D. Evaluation of red cell damage during cardiopulmonary bypass. Scand J Thorac Cardiovasc Surg. 1985;19(3):263–265. doi: 10.3109/14017438509102729. [DOI] [PubMed] [Google Scholar]
  9. Hirayama T., Yamaguchi H., Allers M., Roberts D., William-Olsson G. Changes in red cell deformability associated with anaesthesia and cardiopulmonary bypass in open-heart surgery. Scand J Thorac Cardiovasc Surg. 1985;19(3):257–262. doi: 10.3109/14017438509102728. [DOI] [PubMed] [Google Scholar]
  10. Hong C. Y., Lai L. J., Yeh S. F. Linoleate-rich triacylglycerol in Panax pseudo-ginseng improves erythrocyte deformability in vitro. Planta Med. 1993 Aug;59(4):323–325. doi: 10.1055/s-2006-959691. [DOI] [PubMed] [Google Scholar]
  11. Lichtman M. A., Weed R. I. Divalent cation content of normal and ATP-depleted erythrocytes and erythrocyte membranes. Nouv Rev Fr Hematol. 1972 Nov-Dec;12(6):799–813. [PubMed] [Google Scholar]
  12. NAKAO M., NAKAO T., YAMAZOE S. Adenosine triphosphate and maintenance of shape of the human red cells. Nature. 1960 Sep 10;187:945–946. doi: 10.1038/187945a0. [DOI] [PubMed] [Google Scholar]
  13. Palek J., Stewart G., Lionetti F. J. The dependence of shape of human erythrocyte ghosts on calcium, magnesium, and adenosine triphosphate. Blood. 1974 Oct;44(4):583–597. [PubMed] [Google Scholar]
  14. Reid H. L., Barnes A. J., Lock P. J., Dormandy J. A., Dormandy T. L. A simple method for measuring erythrocyte deformability. J Clin Pathol. 1976 Sep;29(9):855–858. doi: 10.1136/jcp.29.9.855. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Sowemimo-Coker S. O., Kovacs I. B., Kirby J. D., Turner P. Effects of verapamil on calcium-induced rigidity and on filterability of red blood cells from healthy volunteers and patients with progressive systemic sclerosis. Br J Clin Pharmacol. 1985 Jun;19(6):731–737. doi: 10.1111/j.1365-2125.1985.tb02707.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Weed R. I., LaCelle P. L., Merrill E. W. Metabolic dependence of red cell deformability. J Clin Invest. 1969 May;48(5):795–809. doi: 10.1172/JCI106038. [DOI] [PMC free article] [PubMed] [Google Scholar]

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