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. 1995 Feb;39(2):125–129. doi: 10.1111/j.1365-2125.1995.tb04418.x

Reproducibility of angiotensin converting enzyme inhibitor induced cough

A double-blind randomised study

Vincent Charlon, Stuart Dollow, Jose Fidel, Christer Hoglund, Timo Honkanen, Isaac Kobrin, Jean McEwan, Gordon McInnes, J Reuven Viskoper, Kam Sang Woo
PMCID: PMC1364948  PMID: 7742149

Abstract

1 The reproducibility of angiotensin converting enzyme inhibitor induced cough was examined in a double-blind cross over study in patients previously shown to have exhibited this side effect.

2 Ninety-seven patients who had experienced angiotensin converting enzyme inhibitor cough within the last 2 years were challenged with enalapril 20 mg daily for 4 weeks to establish eligibility. Eighty-eight of 97 (91%) patients experienced a repeat of their cough symptoms. Sixty-four patients entered the double-blind part of the study where they were treated with enalapril 20 mg and a renin inhibitor for up to 4 weeks in random order. These periods were separated by a minimum 4 week placebo wash out.

3 Of 59 evaluable patients who received enalapril a second time, 37 (62.7%) experienced cough again. Of 62 patients on the renin inhibitor 16 (25.8%) experienced cough, however as it was not equi-efficacious to enalapril no valid comparison could be made.

4 Angiotensin converting enzyme inhibitor cough is not reproducible within patients, as other factors are involved in the aetiology. Objective testing with blinded assessment together with symptom reporting, would give a more accurate measure of the incidence, and mechanism of this side effect.

Keywords: angiotensin converting enzyme inhibitor, cough, reproducibility, trigger factors, multifactorial

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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