Abstract
The effects of the potassium channel opener levcromakalim (BRL 38227) 7.5 micrograms kg-1 were examined on urodynamic variables and blood pressure during inflow and voiding cystometry in six high spinal cord lesion patients. Levcromakalim administration significantly increased the duration of bladder contraction (197 +/- 128 s to 267 +/- 167 s, P < 0.05) and also reduced blood pressure (126 +/- 13/67 +/- 9 mm Hg to 104 +/- 25/52 +/- 12 mm Hg) but was without effect on other urodynamic parameters. Because of concerns about hypotensive responses, further studies involving higher doses of levcromakalim should be considered only if the drug was administered intravesically.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Andersson K. E. Current concepts in the treatment of disorders of micturition. Drugs. 1988 Apr;35(4):477–494. doi: 10.2165/00003495-198835040-00006. [DOI] [PubMed] [Google Scholar]
- Fall M., Ohlsson B. L., Carlsson C. A. The neurogenic overactive bladder. Classification based on urodynamics. Br J Urol. 1989 Oct;64(4):368–373. doi: 10.1111/j.1464-410x.1989.tb06045.x. [DOI] [PubMed] [Google Scholar]
- Foster C. D., Fujii K., Kingdon J., Brading A. F. The effect of cromakalim on the smooth muscle of the guinea-pig urinary bladder. Br J Pharmacol. 1989 May;97(1):281–291. doi: 10.1111/j.1476-5381.1989.tb11952.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Foster C. D., Speakman M. J., Fujii K., Brading A. F. The effects of cromakalim on the detrusor muscle of human and pig urinary bladder. Br J Urol. 1989 Mar;63(3):284–294. doi: 10.1111/j.1464-410x.1989.tb05191.x. [DOI] [PubMed] [Google Scholar]
- Hamilton T. C., Weir S. W., Weston A. H. Comparison of the effects of BRL 34915 and verapamil on electrical and mechanical activity in rat portal vein. Br J Pharmacol. 1986 May;88(1):103–111. doi: 10.1111/j.1476-5381.1986.tb09476.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Levin R. M., Kitada S., Hayes L., Kau S. T., Fromm-Freeck S., Howe B. B., Wein A. J. Experimental hyperreflexia: effect of intravesical administration of various agents. Pharmacology. 1991;42(1):54–60. doi: 10.1159/000138768. [DOI] [PubMed] [Google Scholar]
- Madersbacher H., Jilg G. Control of detrusor hyperreflexia by the intravesical instillation of oxybutynine hydrochloride. Paraplegia. 1991 Feb;29(2):84–90. doi: 10.1038/sc.1991.11. [DOI] [PubMed] [Google Scholar]
- Malmgren A., Andersson K. E., Andersson P. O., Fovaeus M., Sjögren C. Effects of cromakalim (BRL 34915) and pinacidil on normal and hypertrophied rat detrusor in vitro. J Urol. 1990 Apr;143(4):828–834. doi: 10.1016/s0022-5347(17)40111-x. [DOI] [PubMed] [Google Scholar]
- Malmgren A., Andersson K. E., Sjögren C., Andersson P. O. Effects of pinacidil and cromakalim (BRL 34915) on bladder function in rats with detrusor instability. J Urol. 1989 Oct;142(4):1134–1138. doi: 10.1016/s0022-5347(17)39012-2. [DOI] [PubMed] [Google Scholar]
- Massad C. A., Kogan B. A., Trigo-Rocha F. E. The pharmacokinetics of intravesical and oral oxybutynin chloride. J Urol. 1992 Aug;148(2 Pt 2):595–597. doi: 10.1016/s0022-5347(17)36663-6. [DOI] [PubMed] [Google Scholar]
- Nurse D. E., Restorick J. M., Mundy A. R. The effect of cromakalim on the normal and hyper-reflexic human detrusor muscle. Br J Urol. 1991 Jul;68(1):27–31. doi: 10.1111/j.1464-410x.1991.tb15251.x. [DOI] [PubMed] [Google Scholar]