Abstract
The responses of human isolated umbilical artery to the novel platelet-derived mediators, diadenosine phosphates, P1,P5-di(adenosine-5')pentaphosphate (AP5A) and P1,P6-di(adenosine-5')hexaphosphate (AP6A) were studied in vitro. AP5A (1 nM-300 microM; n = 7) and AP6A (1 nM-30 microM; n = 5) produced transient concentration-dependent contractions. Responses to AP5A were unaffected by co-incubation with indomethacin (10 microM; n = 4), NGmonomethyl-L-arginine (L-NMMA; 300 microM; n = 4) and theophylline (1 microM; n = 5). These results demonstrate that diadenosine phosphates have constrictor effects on human blood vessels in vitro and are consistent with a role for these platelet-derived mediators in the regulation of blood vessel tone.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Gordon J. L. Extracellular ATP: effects, sources and fate. Biochem J. 1986 Jan 15;233(2):309–319. doi: 10.1042/bj2330309. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Klockenbusch W., Braun M. S., Schröder H., Heckenberger R. E., Strobach H., Schrör K. Prostacyclin rather than nitric oxide lowers human umbilical artery tone in vitro. Eur J Obstet Gynecol Reprod Biol. 1992 Nov 19;47(2):109–115. doi: 10.1016/0028-2243(92)90039-2. [DOI] [PubMed] [Google Scholar]
- Lüscher T. F. Platelet-vessel wall interaction: role of nitric oxide, prostaglandins and endothelins. Baillieres Clin Haematol. 1993 Sep;6(3):609–627. doi: 10.1016/s0950-3536(05)80191-x. [DOI] [PubMed] [Google Scholar]
- Mak K. K., Gude N. M., Walters W. A., Boura A. L. Effects of vasoactive autacoids on the human umbilical-fetal placental vasculature. Br J Obstet Gynaecol. 1984 Feb;91(2):99–106. doi: 10.1111/j.1471-0528.1984.tb05890.x. [DOI] [PubMed] [Google Scholar]
- Pohl U., Ogilvie A., Lamontagne D., Busse R. Potent effects of AP3A and AP4A on coronary resistance and autacoid release of intact rabbit hearts. Am J Physiol. 1991 May;260(5 Pt 2):H1692–H1697. doi: 10.1152/ajpheart.1991.260.5.H1692. [DOI] [PubMed] [Google Scholar]
- Schlüter H., Offers E., Brüggemann G., van der Giet M., Tepel M., Nordhoff E., Karas M., Spieker C., Witzel H., Zidek W. Diadenosine phosphates and the physiological control of blood pressure. Nature. 1994 Jan 13;367(6459):186–188. doi: 10.1038/367186a0. [DOI] [PubMed] [Google Scholar]