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. 1967 May;190(2):261–272. doi: 10.1113/jphysiol.1967.sp008206

Gastric secretion during pregnancy and lactation in the rat

B Lilja, S E Svensson
PMCID: PMC1365291  PMID: 4167420

Abstract

1. Gastric acid secretion has been studied in the rat before, during and after pregnancy using different types of stomach preparation. During the same periods the histamine-forming capacity (HFC) has been determined in gastric mucosa and mammary gland.

2. In rats with a whole stomach fistula interdigestive acid secretion is increased during pregnancy and lactation.

3. In rats with a denervated chronic pouch secretory response to stimulation with gastrin and histamine is augmented during pregnancy and lactation.

4. The histamine forming capacity (HFC) of the gastric mucosa is increased 2-3 times during the last days of pregnancy and also during lactation.

5. The HFC of the mammary gland is increased 2-3 times during lactation as compared with the fully developed gland in pregnancy.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ALPHIN R. S., LIN T. M. Preparation of chronic denervated gastric pouches in the rat. Am J Physiol. 1959 Aug;197:257–259. doi: 10.1152/ajplegacy.1959.197.2.257. [DOI] [PubMed] [Google Scholar]
  2. AMURE B. O., GINSBURG M. EFFECTS OF CHLORPROMAZINE AND BROMOLYSERGIC ACID DIETHYLAMIDE ON GASTRIC SECRETION OF ACID INDUCED BY HISTAMINE IN RATS. Br J Pharmacol Chemother. 1964 Jun;22:520–526. doi: 10.1111/j.1476-5381.1964.tb01706.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. CAMPBELL R. M., FELL B. F. GASTRO-INTESTINAL HYPERTROPHY IN THE LACTATING RAT AND ITS RELATION TO FOOD INTAKE. J Physiol. 1964 May;171:90–97. doi: 10.1113/jphysiol.1964.sp007363. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. CLARK D. H. Gastric acid secretion in dogs during pregnancy and lactation. Scott Med J. 1957 Oct;2(10):392–395. doi: 10.1177/003693305700201003. [DOI] [PubMed] [Google Scholar]
  5. CLARK D. H., TANKEL H. I. Gastric acid and plasma-histaminase during pregnancy. Lancet. 1954 Oct 30;267(6844):886–889. doi: 10.1016/s0140-6736(54)92608-2. [DOI] [PubMed] [Google Scholar]
  6. CREAN G. P. THE ENDOCRINE SYSTEM AND THE STOMACH. Vitam Horm. 1963;21:215–280. doi: 10.1016/s0083-6729(08)60242-3. [DOI] [PubMed] [Google Scholar]
  7. FELL B. F., SMITH K. A., CAMPBELL R. M. Hypertrophic and hyperplastic changes in the alimentary canal of the lactating rat. J Pathol Bacteriol. 1963 Jan;85:179–188. doi: 10.1002/path.1700850117. [DOI] [PubMed] [Google Scholar]
  8. GHOSH M. N., SCHILD H. O. Continuous recording of acid gastric secretion in the rat. Br J Pharmacol Chemother. 1958 Mar;13(1):54–61. doi: 10.1111/j.1476-5381.1958.tb00190.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. KAHLSON G., LILJA B., SVENSSON S. E. PHYSIOLOGICAL PROTECTION AGAINST GASTRIC ULCERATION DURING PREGNANCY AND LACTATION IN THE RAT. Lancet. 1964 Dec 12;2(7372):1269–1272. doi: 10.1016/s0140-6736(64)92739-4. [DOI] [PubMed] [Google Scholar]
  10. KAHLSON G., ROSENGREN E., SVAHN D., THUNBERG R. MOBILIZATION AND FORMATION OF HISTAMINE IN THE GASTRIC MUCOSA AS RELATED TO ACID SECRETION. J Physiol. 1964 Nov;174:400–416. doi: 10.1113/jphysiol.1964.sp007494. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. KAHLSON G., ROSENGREN E., THUNBERG R. OBSERVATIONS ON THE INHIBITION OF HISTAMINE FORMATION. J Physiol. 1963 Dec;169:467–486. doi: 10.1113/jphysiol.1963.sp007273. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. KAHLSON G., ROSENGREN E., WESTLING H. Increased formation of histamine in the pregnant rat. J Physiol. 1958 Aug 29;143(1):91–103. doi: 10.1113/jphysiol.1958.sp006046. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. KAHLSON G., ROSENGREN E., WESTLING H., WHITE T. The site of increased formation of histamine in the pregnant rat. J Physiol. 1958 Dec 4;144(2):337–348. doi: 10.1113/jphysiol.1958.sp006105. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. LANE A., IVY A. C., IVY E. K. Response of the chronic gastric fistula rat to histamine. Am J Physiol. 1957 Aug;190(2):221–228. doi: 10.1152/ajplegacy.1957.190.2.221. [DOI] [PubMed] [Google Scholar]
  15. LINDBERG S., LINDELL S. E., WESTLING H. The metabolism of 14-C-labelled histamine injected into the umbilical artery. Acta Obstet Gynecol Scand Suppl. 1963;42(Suppl 1):35–47. doi: 10.3109/00016346309158162. [DOI] [PubMed] [Google Scholar]
  16. MURRAY F. A., ERSKINE J. P., FIELDING J. Gastric secretion in pregnancy. J Obstet Gynaecol Br Emp. 1957 Jun;64(3):373–381. doi: 10.1111/j.1471-0528.1957.tb02656.x. [DOI] [PubMed] [Google Scholar]
  17. McCARTHY J. D., EVANS S. O., DRAGSTEDT L. R. Gastric secretion in dogs during pregnancy and lactation. Gastroenterology. 1954 Sep;27(3):275–280. [PubMed] [Google Scholar]
  18. ROSENGREN E. HISTAMINE METABOLISM IN THE PREGNANT MOUSE. J Physiol. 1963 Dec;169:499–512. doi: 10.1113/jphysiol.1963.sp007275. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. THORNTON G. H., CLIFTON J. A. Estimation of gastric hydrochloric acid secretion in rats by a test meal technique. Am J Physiol. 1959 Aug;197:263–268. doi: 10.1152/ajplegacy.1959.197.2.263. [DOI] [PubMed] [Google Scholar]

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