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. 1968 Sep;198(2):479–485. doi: 10.1113/jphysiol.1968.sp008618

The effect of prolonged exercise on the components of the blood fibrinolytic enzyme system

N B Bennett, C Marie Ogston, D Ogston
PMCID: PMC1365335  PMID: 5698282

Abstract

1. The levels of the blood components of the fibrinolytic enzyme system were measured before, during and after a 4 hr period of exercise in eight subjects.

2. Mean plasminogen activator level rose progressively over the first 3 hr with little further change during the 4th hr of exercise. Following the period of exercise there was a rise in a circulating anti-activator which was still present 20 hr after completion of the exercise.

3. There was no alteration in the mean blood level of plasminogen, fibrinogen, anti-plasmin or a serum inhibitor of plasminogen activation during or following the exercise.

4. The significance of the findings in relation to the mechanism of interaction of the components of the fibrinolytic system is discussed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ALKJAERSIG N., FLETCHER A. P., SHERRY S. The mechanism of clot dissolution by plasmin. J Clin Invest. 1959 Jul;38(7):1086–1095. doi: 10.1172/JCI103885. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. ALKJAERSIG N., FLETCHER A. P., SHERRY S. xi-Aminocaproic acid: an inhibitor of plasminogen activation. J Biol Chem. 1959 Apr;234(4):832–837. [PubMed] [Google Scholar]
  3. Bennett N. B. A method for the quantitative assay of inhibitor of plasminogen activation in human serum. Thromb Diath Haemorrh. 1967 Feb 28;17(1-2):12–22. [PubMed] [Google Scholar]
  4. Bennett N. B., Ogston C. M., Ogston D. Studies on the blood fibrinolytic enzyme system following acute myocardial infarction. Clin Sci. 1967 Feb;32(1):27–37. [PubMed] [Google Scholar]
  5. Cash J. D. Effect of moderate exercise on the fibrinolytic system in normal young men and women. Br Med J. 1966 Aug 27;2(5512):502–506. doi: 10.1136/bmj.2.5512.502. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. FEARNLEY G. R., LACKNER R. The fibrinolytic activity of normal blood. Br J Haematol. 1955 Apr;1(2):189–198. doi: 10.1111/j.1365-2141.1955.tb05500.x. [DOI] [PubMed] [Google Scholar]
  7. FLETCHER A. P., BIEDERMAN O., MOORE D., ALKJAERSIG N., SHERRY S. ABNORMAL PLASMINOGEN-PLASMIN SYSTEM ACTIVITY (FIBRINOLYSIS) IN PATIENTS WITH HEPATIC CIRRHOSIS: ITS CAUSE AND CONSEQUENCES. J Clin Invest. 1964 Apr;43:681–695. doi: 10.1172/JCI104953. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. OGSTON D., FULLERTON H. W. Changes in fibrinolytic activity produced by physical activity. Lancet. 1961 Sep 30;2(7205):730–733. doi: 10.1016/s0140-6736(61)90685-7. [DOI] [PubMed] [Google Scholar]
  9. Ogston C. M., Ogston D. Plasma fibrinogen and plasminogen levels in health and in ischaemic heart disease. J Clin Pathol. 1966 Jul;19(4):352–356. doi: 10.1136/jcp.19.4.352. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. RATNOFF O. D., MENZIE C. A new method for the determination of fibrinogen in small samples of plasma. J Lab Clin Med. 1951 Feb;37(2):316–320. [PubMed] [Google Scholar]
  11. SAWYER W. D., FLETCHER A. P., ALKJAERSIN N., SHERRY S. Studies on the thrombolytic activity of human plasma. J Clin Invest. 1960 Feb;39:426–434. doi: 10.1172/JCI104054. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. SHERRY S., FLETCHER A. P., ALKJAERSIG N. Fibrinolysis and fibrinolytic activity in man. Physiol Rev. 1959 Apr;39(2):343–382. doi: 10.1152/physrev.1959.39.2.343. [DOI] [PubMed] [Google Scholar]
  13. SHERRY S., LINDEMEYER R. I., FLETCHER A. P., ALKJAERSIG N. Studies on enhanced fibrinolytic activity in man. J Clin Invest. 1959 May;38(5):810–822. doi: 10.1172/JCI103863. [DOI] [PMC free article] [PubMed] [Google Scholar]

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