The effect of serum on the uptake of thyroid hormones by the perfused rat heart

. 1968 Nov;199(1):161–168. doi: 10.1113/jphysiol.1968.sp008645

PMCID: PMC1365350 PMID: 4971701

Abstract

1. The effect of serum on the uptake of radioactive L-thyroxine and L-3,5,3′-tri-iodothyronine has been studied in the perfused rat heart.

2. With thyroxine binding protein (rat serum) in the perfusion fluid the uptake of both hormones is much reduced.

3. This inhibitory effect of serum on hormone uptake is greater with thyroxine than with tri-iodothyronine.

4. Serum in the perfusion fluid accelerates the release of accumulated thyroid hormone from the rat heart.

5. High concentrations of thyroxine increased the thyroxine space of hearts perfused by solutions containing serum.

These references are in PubMed. This may not be the complete list of references from this article.

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