Abstract
1. Occlusion of the main left coronary artery of lightly anaesthetized cats provoked a pseudaffective reaction. The afferent pathway was in the cardiac sympathetic nerves.
2. The compound action potential evoked in the inferior or middle cardiac nerves by stimulation of the thoracic sympathetic trunk contained two elevations, a small Aδ wave and a much larger sC wave. Occasionally a B wave was present.
3. During coronary occlusion, the Aδ elevation was reduced by 35-55%, indicating afferent activity in these fibres. Multifibre preparations also showed increased afferent discharge during occlusion.
4. It seems probable that the afferent activity in these fibres was mainly responsible for signalling the pseudaffective response elicited by coronary occlusion.
5. Myocardial ischaemia produced by coronary occlusion was probably the stimulus for the increased activity.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- BESSOU P., LAPORTE Y. Activation des fibres afférentes amyéliniques d'origine musculaire. C R Seances Soc Biol Fil. 1958;152(11):1587–1590. [PubMed] [Google Scholar]
- Brown A. M. The depressor reflex arising from the left coronary artery of the cat. J Physiol. 1966 Jun;184(4):825–836. doi: 10.1113/jphysiol.1966.sp007950. [DOI] [PMC free article] [PubMed] [Google Scholar]
- DOUGLAS W. W., RITCHIE J. M. A technique for recording functional activity in specific groups of medullated and non-medullated fibres in whole nerve trunks. J Physiol. 1957 Aug 29;138(1):19–30. doi: 10.1113/jphysiol.1957.sp005835. [DOI] [PMC free article] [PubMed] [Google Scholar]
- DOUGLAS W. W., RITCHIE J. M. Mammalian nonmyelinated nerve fibers. Physiol Rev. 1962 Apr;42:297–334. doi: 10.1152/physrev.1962.42.2.297. [DOI] [PubMed] [Google Scholar]
- GASSER H. S. Unmedullated fibers originating in dorsal root ganglia. J Gen Physiol. 1950 Jul 20;33(6):651–690. doi: 10.1085/jgp.33.6.651. [DOI] [PMC free article] [PubMed] [Google Scholar]
- HIRSCH E. F., BORGHARD-ERDLE A. M. The innervation of the human heart. I. The coronary arteries and the myocardium. Arch Pathol. 1961 Apr;71:384–407. [PubMed] [Google Scholar]
- HOLMES R., TORRANCE R. W. Afferent fibres of the stellate ganglion. Q J Exp Physiol Cogn Med Sci. 1959 Jul;44:271–281. doi: 10.1113/expphysiol.1959.sp001400. [DOI] [PubMed] [Google Scholar]
- Matthews B. H. Nerve endings in mammalian muscle. J Physiol. 1933 Apr 13;78(1):1–53. doi: 10.1113/jphysiol.1933.sp002984. [DOI] [PMC free article] [PubMed] [Google Scholar]
- WHITE J. C. Cardiac pain: anatomic pathways and physiologic mechanisms. Circulation. 1957 Oct;16(4):644–655. doi: 10.1161/01.cir.16.4.644. [DOI] [PubMed] [Google Scholar]
- Woollard H. H. The Innervation of the Heart. J Anat. 1926 Jul;60(Pt 4):345–373. [PMC free article] [PubMed] [Google Scholar]