Skip to main content
NCBI home page
The Journal of Physiology logoLink to The Journal of Physiology
. 1967 Jun;190(3):455–463. doi: 10.1113/jphysiol.1967.sp008221

Accelerated mobilization and formation of histamine in the gastric mucosa evoked by vagal excitation

G Kahlson, Elsa Rosengren, R Thunberg
PMCID: PMC1365421  PMID: 4167631

Abstract

1. The changes in the rate of histamine formation and in the histamine content of the parietal cell containing region of the gastric mucosa have been studied in rats under the influence of agents which evoke or abolish vagal excitation.

2. The hypoglycaemia producing agents, insulin and 2-deoxyglucose (2-DG), raised the mucosal histamine-forming capacity (HFC) in a way similar to that previously observed on re-feeding, gastrin injection, and distension of the stomach wall.

3. In cats, insulin injection elicited an elevation of mucosal HFC similar to the corresponding effect of insulin in rats.

4. Hoechst 9980, which inhibits post-ganglionic cholinergic transmission, counteracted the elevation of mucosal HFC following vagal excitation, but did not inhibit changes produced by gastrin, thus indicating the absence of a cholinergic intermediary link between gastrin and changes in mucosal histamine.

5. It is emphasized that although re-feeding, vagus excitation, gastrin and distension all produce similar changes in mucosal histamine, the clarification of the precise role of histamine as a natural stimulant for the parietal cells may require a fresh kind of approach.

Full text

PDF
455

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Babkin B. P. THE ABNORMAL FUNCTIONING OF THE GASTRIC SECRETORY MECHANISM AS A POSSIBLE FACTOR IN THE PATHOGENESIS OF PEPTIC ULCER. Can Med Assoc J. 1938 May;38(5):421–429. [PMC free article] [PubMed] [Google Scholar]
  2. Bennett A. Effect of gastrin on isolated smooth muscle preparation. Nature. 1965 Oct 9;208(5006):170–173. doi: 10.1038/208170a0. [DOI] [PubMed] [Google Scholar]
  3. CLARK C. G., CURNOW V. J., MURRAY J. G., STEPHENS F. O., WYLLIE J. H. MODE OF ACTION OF HISTAMINE IN CAUSING GASTRIC SECRETION IN MAN. Gut. 1964 Dec;5:537–545. doi: 10.1136/gut.5.6.537. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Code C. F. Histamine and gastric secretion: a later look, 1955-1965. Fed Proc. 1965 Nov-Dec;24(6):1311–1321. [PubMed] [Google Scholar]
  5. EMMELIN N., HENRIKSSON K. G. Depressor activity of saliva after section of the chorda tympani. Acta Physiol Scand Suppl. 1953;111:75–82. [PubMed] [Google Scholar]
  6. GREEN H., ERICKSON R. W. EFFECT OF SOME DRUGS UPON RAT BRAIN HISTAMINE CONTENT. Int J Neuropharmacol. 1964 Jul;3:315–320. doi: 10.1016/0028-3908(64)90023-1. [DOI] [PubMed] [Google Scholar]
  7. HAEGER K., KAHLSON G. Distribution of histamine and histaminase in the gastro-intestinal mucosa of fed and starved cats. Acta Physiol Scand. 1952 Jun 6;25(2-3):230–242. doi: 10.1111/j.1748-1716.1952.tb00875.x. [DOI] [PubMed] [Google Scholar]
  8. HAEGER K., KAHLSON G., WESTLING H. Evidence of a regulatory mechanism controlling the levels of histamine and histaminase in the gastro-intestinal tract. Acta Physiol Scand Suppl. 1953;111:177–191. [PubMed] [Google Scholar]
  9. HAVERBACK B. J., TECIMER L. B., DYCE B. J., COHEN M., STUBRIN M. I., SANTAANA A. D. THE EFFECT OF GASTRIN ON STOMACH HISTAMINE IN THE RAT. Life Sci. 1964 Jun;3:637–649. doi: 10.1016/0024-3205(64)90178-x. [DOI] [PubMed] [Google Scholar]
  10. HIGH D. P., SHEPHERD D. M., WOODCOCK B. G. URINARY HISTAMINE EXCRETION IN THE GASTRECTOMISED RAT. Life Sci. 1965 Apr;4:787–795. doi: 10.1016/0024-3205(65)90311-5. [DOI] [PubMed] [Google Scholar]
  11. Haverback B. J., Stubrin M. I., Dyce B. J. Relationship of histamine to gastrin and other secretagogues. Fed Proc. 1965 Nov-Dec;24(6):1326–1330. [PubMed] [Google Scholar]
  12. Hirschowitz B. I., Sachs G. Vagal gastric secretory stimulation by 2-deoxy-D-glucose. Am J Physiol. 1965 Sep;209(3):452–460. doi: 10.1152/ajplegacy.1965.209.3.452. [DOI] [PubMed] [Google Scholar]
  13. KAHLSON G., ROSENGREN E., SVAHN D., THUNBERG R. MOBILIZATION AND FORMATION OF HISTAMINE IN THE GASTRIC MUCOSA AS RELATED TO ACID SECRETION. J Physiol. 1964 Nov;174:400–416. doi: 10.1113/jphysiol.1964.sp007494. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. KAHLSON G., ROSENGREN E., THUNBERG R. OBSERVATIONS ON THE INHIBITION OF HISTAMINE FORMATION. J Physiol. 1963 Dec;169:467–486. doi: 10.1113/jphysiol.1963.sp007273. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. KIM K. S., SHORE P. A. MECHANISM OF ACTION OF RESERPINE AND INSULIN ON GASTRIC AMINES AND GASTRIC ACID SECRETION, AND THE EFFECT OF MONOAMINE OXIDASE INHIBITION. J Pharmacol Exp Ther. 1963 Sep;141:321–325. [PubMed] [Google Scholar]
  16. LANE A., IVY A. C., IVY E. K. Response of the chronic gastric fistula rat to histamine. Am J Physiol. 1957 Aug;190(2):221–228. doi: 10.1152/ajplegacy.1957.190.2.221. [DOI] [PubMed] [Google Scholar]
  17. Levine R. J. Effect of histidine decarboxylase inhibition on gastric acid secretion in the rat. Fed Proc. 1965 Nov-Dec;24(6):1331–1333. [PubMed] [Google Scholar]
  18. ROSENGREN E. HISTAMINE METABOLISM IN THE PREGNANT MOUSE. J Physiol. 1963 Dec;169:499–512. doi: 10.1113/jphysiol.1963.sp007275. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. SCHAYER R. W., IVY A. C. Evidence that histamine is a gastric secretory hormone in the rat. Am J Physiol. 1957 May;189(2):369–372. doi: 10.1152/ajplegacy.1957.189.2.369. [DOI] [PubMed] [Google Scholar]
  20. SCHAYER R. W., IVY A. C. Release of C14-histamine from stomach and intestine on feeding. Am J Physiol. 1958 May;193(2):400–402. doi: 10.1152/ajplegacy.1958.193.2.400. [DOI] [PubMed] [Google Scholar]
  21. SHORE P. A., BURKHALTER A., COHN V. H., Jr A method for the fluorometric assay of histamine in tissues. J Pharmacol Exp Ther. 1959 Nov;127:182–186. [PubMed] [Google Scholar]
  22. Shore P. A. Release of histamine from stomach by vagus-stimulating drugs: association with gastric acid secretion. Fed Proc. 1965 Nov-Dec;24(6):1322–1325. [PubMed] [Google Scholar]
  23. WIDDICOMBE J. G. Receptors in the trachea and bronchi of the cat. J Physiol. 1954 Jan;123(1):71–104. doi: 10.1113/jphysiol.1954.sp005034. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. White T. Histamine and methylhistamine in cat brain and other tissues. Br J Pharmacol Chemother. 1966 Feb;26(2):494–501. doi: 10.1111/j.1476-5381.1966.tb01930.x. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from The Journal of Physiology are provided here courtesy of The Physiological Society

RESOURCES