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. 1967 Jul;191(2):393–405. doi: 10.1113/jphysiol.1967.sp008257

The effect of thyrocalcitonin on blood—bone calcium equilibrium in the perfused tibia of the cat

I Macintyre, J A Parsons, C J Robinson
PMCID: PMC1365460  PMID: 6058243

Abstract

1. In the isolated tibia of the cat, perfused with blood from its own carotid connected to popliteal artery via a pump, infusion of porcine thyrocalcitonin causes an arteriovenous difference in calcium concentration of up to 5%, corresponding to net retention of calcium in bone.

2. When taken in conjunction with determinations of radiocalcium clearance in the tibia, the effect is of the right order of magnitude to account for the hypocalcaemic action of thyrocalcitonin in the whole animal.

3. Calcium retention was accompanied by a small increase in acidity of outflowing venous blood whereas verification of the hypothesis of calcium regulation by pH change in the bone substance would require a decrease.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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