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. 1967 Dec;193(3):631–637. doi: 10.1113/jphysiol.1967.sp008383

The effect of ouabain on the secretion of catecholamines and on the intracellular concentration of potassium

P Banks
PMCID: PMC1365518  PMID: 16992301

Abstract

1. Perfusion of bovine adrenal glands with 0.1 mM ouabain is accompanied by a doubling of the spontaneous rate of release of catecholamines and by a 66% increase in the response to stimulation with carbamylcholine.

2. Perfusion with ouabain (0.1 mM) reduces the intracellular content of potassium from 106 to 63 mM.

3. The effect of ouabain on catecholamine secretion is dependent upon the presence of Ca2+ ions in contrast to the effect upon the potassium content which is not dependent upon the presence of calcium.

4. Ouabain has no effect on the release of catecholamines from isolated chromaffin granules both in the presence and absence of Ca2+ ions.

5. A possible relationship between the secretion of catecholamines and the concentration gradient of potassium across the cell membrane is discussed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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