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. 1967 Oct;192(3):761–772. doi: 10.1113/jphysiol.1967.sp008329

Distribution of chylomicrons and albumin in dog kidney

G G Pinter
PMCID: PMC1365540  PMID: 6059001

Abstract

1. Under specified experimental conditions the distribution space of labelled chylomicrons in the kidney was 13·8 ± 0·9 ml./100 g. tissue. The assumption is supported that this provides a measure for the quantity of intravascular plasma constituents.

2. Values for red blood cells and albumin distribution spaces were 5·2 ± 0·6 and 20·2 ± 1·0 ml./100 g tissue, respectively, in the whole kidney. The ratio of tissue haematocrit over simultaneous arterial haematocrit averaged 0·56. The extravascular albumin fraction amounted to about 31·0% of the total albumin in the whole kidney.

3. A statistically significant correlation was demonstrated between osmotic urine/plasma (U/P) ratios (within the approximate limits of 0·6-1·8) and quantities of extravascular albumin in the medulla.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BRAGDON J. H., GORDON R. S., Jr Tissue distribution of C14 after the intravenous injection of labeled chylomicrons and unesterified fatty acids in the rat. J Clin Invest. 1958 Apr;37(4):574–578. doi: 10.1172/JCI103640. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. CHINARD F. P., ENNS T., NOLAN M. F. ARTERIAL HEMATOCRIT AND SEPARATION OF CELLS AND PLASMA IN THE DOG KIDNEY. Am J Physiol. 1964 Jul;207:128–132. doi: 10.1152/ajplegacy.1964.207.1.128. [DOI] [PubMed] [Google Scholar]
  3. Carone F. A., Everett B. A., Blondeel N. J., Stolarczyk J. Renal localization of albumin and its function in the concentrating mechanism. Am J Physiol. 1967 Feb;212(2):387–393. doi: 10.1152/ajplegacy.1967.212.2.387. [DOI] [PubMed] [Google Scholar]
  4. EMERY E. W., GOWENLOCK A. H., RIDDELL A. G., BLACK D. A. Intrarenal variations in haematocrit. Clin Sci. 1959 May;18:205–221. [PubMed] [Google Scholar]
  5. FRENCH J. E., MORRIS B. The tissue distribution and oxidation of 14C-labelled chylomicron fat injected intravenously in rats. J Physiol. 1958 Feb 17;140(2):262–271. doi: 10.1113/jphysiol.1958.sp005932. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. GOODMAN D. S. The metabolism of chylomicron cholesterol ester in the rat. J Clin Invest. 1962 Oct;41:1886–1896. doi: 10.1172/JCI104645. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Hársing L., Bartha J., Harza T., Pelley K. Sodium and potassium concentration and blood flow in the renal cortex and medulla during different diuretic responses. Acta Physiol Acad Sci Hung. 1966;30(3):215–224. [PubMed] [Google Scholar]
  8. KINTER W. B., PAPPENHEIMER J. R. Renal extraction of PAH and of diodrast-I131 as a function of arterial red cell concentration. Am J Physiol. 1956 May;185(2):391–398. doi: 10.1152/ajplegacy.1956.185.2.391. [DOI] [PubMed] [Google Scholar]
  9. KINTER W. B., PAPPENHEIMER J. R. Role of red blood corpuscles in regulation of renal blood flow and glomerular filtration rate. Am J Physiol. 1956 May;185(2):399–406. doi: 10.1152/ajplegacy.1956.185.2.399. [DOI] [PubMed] [Google Scholar]
  10. LAPP H., NOLTE A. [Comparative electron microscope studies on the medulla of the rat kidney based on urine concentration and urine dilution]. Frankf Z Pathol. 1962;71:617–633. [PubMed] [Google Scholar]
  11. LAURENT T. C., OGSTON A. G. THE INTERACTION BETWEEN POLYSACCHARIDES AND OTHER MACROMOLECULES. 4. THE OSMOTIC PRESSURE OF MIXTURES OF SERUM ALBUMIN AND HYALURONIC ACID. Biochem J. 1963 Nov;89:249–253. doi: 10.1042/bj0890249. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. LILIENFIELD L. S., ROSE J. C., LASSEN N. A. Diverse distribution of red cells and albumin in the dog kidney. Circ Res. 1958 Nov;6(6):810–815. doi: 10.1161/01.res.6.6.810. [DOI] [PubMed] [Google Scholar]
  13. Lassiter W. E., Mylle M., Gottschalk C. W. Micropuncture study of urea transport in rat renal medulla. Am J Physiol. 1966 May;210(5):965–970. doi: 10.1152/ajplegacy.1966.210.5.965. [DOI] [PubMed] [Google Scholar]
  14. OCHWADT B. Durchflusszeiten von Plasma und Erythrocyten, intrarenaler Hamatokrit und Widerstandsregulation der isolierten Niere. Pflugers Arch. 1957;265(2):112–116. doi: 10.1007/BF00364561. [DOI] [PubMed] [Google Scholar]
  15. OGSTON A. G. Some thermodynamic relationships in ternary systems, with special reference to the properties of systems containing hyaluronic acid and protein. Arch Biochem Biophys. 1962 Sep;Suppl 1:39–51. [PubMed] [Google Scholar]
  16. PAPPENHEIMER J. R., KINTER W. B. Hematocrit ratio of blood within mammalian kidney and its significance for renal hemodynamics. Am J Physiol. 1956 May;185(2):377–390. doi: 10.1152/ajplegacy.1956.185.2.377. [DOI] [PubMed] [Google Scholar]
  17. PEASE D. C. Electron microscopy of the vascular bed of the kidney cortex. Anat Rec. 1955 Apr;121(4):701–721. doi: 10.1002/ar.1091210402. [DOI] [PubMed] [Google Scholar]
  18. PINTER G. G., O'MORCHOE C. C., SIKAND R. S. EFFECT OF ACETYLCHOLINE ON URINARY ELECTROLYTE EXCRETION. Am J Physiol. 1964 Nov;207:979–982. doi: 10.1152/ajplegacy.1964.207.5.979. [DOI] [PubMed] [Google Scholar]
  19. PINTER G. G., ZILVERSMIT D. B. A gradient centrifugation method for the determination of particle size distribution of chylomicrons and of fat droplets in artificial fat emulsions. Biochim Biophys Acta. 1962 May 7;59:116–127. doi: 10.1016/0006-3002(62)90702-3. [DOI] [PubMed] [Google Scholar]
  20. POLOSA C., HAMILTON W. F. The relation between cells and plasma within the renal vasculature. Arch Int Pharmacodyn Ther. 1962 Nov 1;140:294–307. [PubMed] [Google Scholar]
  21. Pedersen F., Baerenholdt O. Mean circulation time and fastest circulation time for red cells and plasma in the human kidney measured by an external counting method. Scand J Clin Lab Invest. 1966;18(2):245–253. doi: 10.3109/00365516609051821. [DOI] [PubMed] [Google Scholar]
  22. Preston B. N., Davies M., Ogston A. G. The composition and physicochemical properties of hyaluronic acids prepared from ox synovial fluid and from a case of mesothelioma. Biochem J. 1965 Aug;96(2):449–474. doi: 10.1042/bj0960449. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. SWANN H. G. The functional distension of the kidney: a review. Tex Rep Biol Med. 1960;18:566–595. [PubMed] [Google Scholar]
  24. Slotkoff L. M., Lilienfield L. S. Extravascular renal albumin. Am J Physiol. 1967 Feb;212(2):400–406. doi: 10.1152/ajplegacy.1967.212.2.400. [DOI] [PubMed] [Google Scholar]
  25. ULFENDAHL H. R. Distribution of red cells and plasma in rabbit and cat kidneys. Acta Physiol Scand. 1962 Sep;56:42–60. doi: 10.1111/j.1748-1716.1962.tb02481.x. [DOI] [PubMed] [Google Scholar]
  26. WEAVER A. N., MCCARVER C. T., SWANN H. G. Distribution of blood in the functional kidney. J Exp Med. 1956 Jul 1;104(1):41–52. doi: 10.1084/jem.104.1.41. [DOI] [PMC free article] [PubMed] [Google Scholar]

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