Abstract
1. Changes in temperature were determined following injection of noradrenaline, adrenaline, isoprenaline, dopamine and 5-hydroxytryptamine (5-HT) into the cerebral ventricles of the conscious mouse.
2. Noradrenaline (1-20 μg) and dopamine (10-160 μg) caused falls in body temperature. Adrenaline (1-20 μg) caused a slight and transient rise in body temperature followed by a fall. Isoprenaline (5-20 μg) caused a rise in body temperature, hypothermia only occurring after very high doses (200 μg) of this catecholamine.
3. α- and β-adrenergic blocking agents, phentolamine (> 2 μg) and propranolol (> 5 μg) respectively, caused falls in body temperature when injected into the cerebral ventricles of the mouse.
4. Specific drug antagonism studies were limited owing to the intrinsic effects of the α- and β-adrenergic blocking agents. However, some evidence was obtained to indicate that noradrenaline mediated its effects through a central α-type adrenergic receptor.
5. 5-HT (10-160 μg) caused a fall in body temperature. The action of this indoleamine and the catecholamines in regard to thermoregulatory function is discussed.
Full text
PDF![805](https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2261/1365543/795cdc5625c6/jphysiol01117-0226.png)
![806](https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2261/1365543/92f144706c42/jphysiol01117-0227.png)
![807](https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2261/1365543/b28e81e536d0/jphysiol01117-0228.png)
![808](https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2261/1365543/2c7309fddaea/jphysiol01117-0229.png)
![809](https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2261/1365543/28ab6a1da5b1/jphysiol01117-0230.png)
![810](https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2261/1365543/f86571d080b2/jphysiol01117-0231.png)
![811](https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2261/1365543/3aa8f5bbdd90/jphysiol01117-0232.png)
![812](https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2261/1365543/4f91999a6aaf/jphysiol01117-0233.png)
![813](https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2261/1365543/6a88aac11f48/jphysiol01117-0234.png)
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- BLACK J. W., CROWTHER A. F., SHANKS R. G., SMITH L. H., DORNHORST A. C. A NEW ADRENERGIC BETARECEPTOR ANTAGONIST. Lancet. 1964 May 16;1(7342):1080–1081. doi: 10.1016/s0140-6736(64)91275-9. [DOI] [PubMed] [Google Scholar]
- BRITTAIN R. T., SPENCER P. S. MEASUREMENT OF BODY TEMPERATURE IN CONSCIOUS SMALL LABORATORY ANIMALS BY MEANS OF AN OESOPHAGEAL THERMOCOUPLE. J Pharm Pharmacol. 1964 Jul;16:497–499. doi: 10.1111/j.2042-7158.1964.tb07501.x. [DOI] [PubMed] [Google Scholar]
- Brittain R. T. The intracerebral effects of noradrenaline and its modification by drugs in the mouse. J Pharm Pharmacol. 1966 Sep;18(9):621–623. doi: 10.1111/j.2042-7158.1966.tb07944.x. [DOI] [PubMed] [Google Scholar]
- CORNE S. J., PICKERING R. W., WARNER B. T. A method for assessing the effects of drugs on the central actions of 5-hydroxytryptamine. Br J Pharmacol Chemother. 1963 Feb;20:106–120. doi: 10.1111/j.1476-5381.1963.tb01302.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Cooper K. E., Cranston W. I., Honour A. J. Effects of intraventricular and intrahypothalamic injection of noradrenaline and 5-HT on body temperature in conscious rabbits. J Physiol. 1965 Dec;181(4):852–864. doi: 10.1113/jphysiol.1965.sp007801. [DOI] [PMC free article] [PubMed] [Google Scholar]
- FELDBERG W., MYERS R. D. EFFECTS ON TEMPERATURE OF AMINES INJECTED INTO THE CEREBRAL VENTRICLES. A NEW CONCEPT OF TEMPERATURE REGULATION. J Physiol. 1964 Sep;173:226–231. doi: 10.1113/jphysiol.1964.sp007454. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Feldberg W., Hellon R. F., Myers R. D. Effects on temperature of monoamines injected into the cerebral ventricles of anaesthetized dogs. J Physiol. 1966 Oct;186(2):416–423. doi: 10.1113/jphysiol.1966.sp008043. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Feldberg W., Lotti V. J. Temperature changes produced in the unanaesthetized rat by monoamines and tranylcypromine injected into the cerebral ventricles. J Physiol. 1967 Jul;191(1):35P–36P. [PubMed] [Google Scholar]
- HALEY T. J., MCCORMICK W. G. Pharmacological effects produced by intracerebral injection of drugs in the conscious mouse. Br J Pharmacol Chemother. 1957 Mar;12(1):12–15. doi: 10.1111/j.1476-5381.1957.tb01354.x. [DOI] [PMC free article] [PubMed] [Google Scholar]