Skip to main content
The Journal of Physiology logoLink to The Journal of Physiology
. 1967 Nov;193(1):131–140. doi: 10.1113/jphysiol.1967.sp008347

The effect of stress on the concentration of 3β-hydroxypregn-5-en-20-one (pregnenolone) and pregn-4-ene-3,20-dione (progesterone) in the adrenal gland of the rat

Margarethe Holzbauer, Helen M Newport
PMCID: PMC1365586  PMID: 16992280

Abstract

1. Pregnenolone and progesterone were estimated in extracts from adrenal glands of rats by gas—liquid chromatography.

2. In unstressed rats their concentrations were found to be smaller than that of corticosterone.

3. Acute stress caused an increase in the concentrations of these steroids which paralleled that of corticosterone.

Full text

PDF
131

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BUSH I. E., SANDBERG A. A. Adrenocortical hormones in human plasma. J Biol Chem. 1953 Dec;205(2):783–793. [PubMed] [Google Scholar]
  2. BUSH I. E. Species differences in adrenocortical secretion. J Endocrinol. 1953 Jan;9(1):95–100. doi: 10.1677/joe.0.0090095. [DOI] [PubMed] [Google Scholar]
  3. EBERLEIN W. R., BONGIOVANNI A. M. New solvent systems for the resolution of corticosteroids by paper chromatography. Arch Biochem Biophys. 1955 Nov;59(1):90–96. doi: 10.1016/0003-9861(55)90465-3. [DOI] [PubMed] [Google Scholar]
  4. HEAP R. B. A FLUORESCENCE ASSAY OF PROGESTERONE. J Endocrinol. 1964 Oct;30:293–305. doi: 10.1677/joe.0.0300293. [DOI] [PubMed] [Google Scholar]
  5. HENNING H. D., ZANDER J. [Use of Huebener's 20 beta-hydroxysteroid dehydrogenase in the microchemical identification and separation of steroids]. Hoppe Seylers Z Physiol Chem. 1962 Dec 15;330:31–37. doi: 10.1515/bchm2.1962.330.1.31. [DOI] [PubMed] [Google Scholar]
  6. HOLZBAUER M. The corticosterone content of rat adrenals under different experimental conditions. J Physiol. 1957 Dec 3;139(2):294–305. doi: 10.1113/jphysiol.1957.sp005891. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Heap R. B., Holzbauer M., Newport H. M. Adrenal secretion rates of C-19 and C-21 steroids before and after hypophysectomy in the pig and the dog. J Endocrinol. 1966 Oct;36(2):159–176. doi: 10.1677/joe.0.0360159. [DOI] [PubMed] [Google Scholar]
  8. Holzbauer M., Newport H. M. Evidence for the presence of 16 alpha-hydroxypregn-4-ene-3,20-dione in adrenal venous blood of young pigs. J Physiol. 1967 Aug;191(3):691–697. doi: 10.1113/jphysiol.1967.sp008275. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. PERON F. G. Isolation of 18-hydroxydeoxycorticosterone from rat adrenals. Endocrinology. 1961 Jul;69:39–45. doi: 10.1210/endo-69-1-39. [DOI] [PubMed] [Google Scholar]
  10. STONE D., HECHTER O. Studies on ACTH action in perfused bovine adrenals: the site of action of ACTH in corticosteroidogenesis. Arch Biochem Biophys. 1954 Aug;51(2):457–469. doi: 10.1016/0003-9861(54)90501-9. [DOI] [PubMed] [Google Scholar]
  11. VOGT M. Inhibition by hexoestrol of adrenocortical secretion in the rat. J Physiol. 1955 Dec 29;130(3):601–614. doi: 10.1113/jphysiol.1955.sp005430. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from The Journal of Physiology are provided here courtesy of The Physiological Society

RESOURCES