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. 1968 Jan;194(1):237–248. doi: 10.1113/jphysiol.1968.sp008404

Some effects of ouabain and potassium on transport and metabolism in rat small intestine

H Newey, P A Sanford, D H Smyth
PMCID: PMC1365684  PMID: 5639772

Abstract

1. Ouabain (10-3 M) inhibited the transfer of glucose, proline, methionine and fluid but not of galactose and 3-O-methyl glucose by sacs of rat everted intestine.

2. Ouabain (10-3 M) inhibited both glucose and mannose metabolism. Hexose metabolism was also reduced by varying the [K] from 4·8 m-equiv/l.

3. Ouabain (10-3 M) or absence of K reduced the stimulation of amino acid, hexose and fluid transfer by mannose. Although presence of ouabain or absence of K did not inhibit endogenous galactose transfer, these conditions prevented mannose from stimulating this transfer.

4. Ouabain (10-3 M) exerted greater effects on hexose and amino acid transfer when K was omitted from the saline and its inhibitory effects were partially overcome by increased serosal [K].

5. Ouabain (10-2 M) caused further inhibition of amino acid and glucose transfer and also reduced the transfer of galactose and 3-O-methyl glucose.

6. The implications of these results are discussed with respect to the relationships between cations and hexose and amino acid transfer.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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