Abstract
Two classes of DNA have been distinguished on the basis of their reaction to heating in cesium chloride. DNA from proliferating sources is cleaved in half by such treatment, whereas DNA from non-proliferating sources is unaffected in molecular weight. This has been shown by two independent techniques. The relationship between the molecular units produced by cesium chloride treatment and the units conserved during DNA replication is discussed.
Full text
PDFSelected References
These references are in PubMed. This may not be the complete list of references from this article.
- CAVALIERI L. F., ROSENBERG B. H. The replication of DNA III. Changes in the number of strands in E. coli DNA during its replication cycle. Biophys J. 1961 Mar;1:337–351. doi: 10.1016/s0006-3495(61)86893-8. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Cavalieri L. F., Deutsch J. F., Rosenberg B. H. The Molecular Weight and Aggregation of DNA. Biophys J. 1961 Mar;1(4):301–315. doi: 10.1016/s0006-3495(61)86890-2. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Meselson M., Stahl F. W. THE REPLICATION OF DNA IN ESCHERICHIA COLI. Proc Natl Acad Sci U S A. 1958 Jul 15;44(7):671–682. doi: 10.1073/pnas.44.7.671. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Meselson M., Stahl F. W., Vinograd J. EQUILIBRIUM SEDIMENTATION OF MACROMOLECULES IN DENSITY GRADIENTS. Proc Natl Acad Sci U S A. 1957 Jul 15;43(7):581–588. doi: 10.1073/pnas.43.7.581. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Rolfe R., Meselson M. THE RELATIVE HOMOGENEITY OF MICROBIAL DNA. Proc Natl Acad Sci U S A. 1959 Jul;45(7):1039–1043. doi: 10.1073/pnas.45.7.1039. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Sueoka N. A STATISTICAL ANALYSIS OF DEOXYRIBONUCLEIC ACID DISTRIBUTION IN DENSITY GRADIENT CENTRIFUGATION. Proc Natl Acad Sci U S A. 1959 Oct;45(10):1480–1490. doi: 10.1073/pnas.45.10.1480. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Sueoka N. MITOTIC REPLICATION OF DEOXYRIBONUCLEIC ACID IN CHLAMYDOMONAS REINHARDI. Proc Natl Acad Sci U S A. 1960 Jan;46(1):83–91. doi: 10.1073/pnas.46.1.83. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Taylor J. H., Woods P. S., Hughes W. L. THE ORGANIZATION AND DUPLICATION OF CHROMOSOMES AS REVEALED BY AUTORADIOGRAPHIC STUDIES USING TRITIUM-LABELED THYMIDINEE. Proc Natl Acad Sci U S A. 1957 Jan 15;43(1):122–128. doi: 10.1073/pnas.43.1.122. [DOI] [PMC free article] [PubMed] [Google Scholar]