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. 1962 May;2(3):249–256. doi: 10.1016/s0006-3495(62)86853-2

Hyperchromicity and Strand Separation in Bacterial DNA

David Freifelder, Peter F Davison
PMCID: PMC1366370  PMID: 13894962

Abstract

Studies of the per cent of strand separation of N14-N15 hybrid coli DNA heated to various temperatures in formaldehyde have shown that the process of strand separation is a function of temperature and formaldehyde concentration and is directly related to the measured hyperchromicity. No strands separate until about 75 per cent of full hyperchromicity is obtained, and even at apparently full hyperchromicity a large fraction of the strands may be held together, possibly by guanine-cytosine-rich regions.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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