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. 1963 Jan;3(1):49–63. doi: 10.1016/s0006-3495(63)86803-4

Physicochemical Studies on the Reaction between Formaldehyde and DNA

David Freifelder, Peter F Davison
PMCID: PMC1366423  PMID: 13959526

Abstract

The reaction between formaldehyde and phage T7 DNA has been studied by optical absorbance and sedimentation measurements. Through the course of denaturation, OD200 and s20, w rise; after the attainment of full hyperchromicity the s20, w falls sharply, suggesting a decrease in molecular weight. Conditions in which formaldehyde causes cross-linking are defined. Some experimental applications of the denaturation technique are given. Evidence which suggests that preformed single-strand interruptions may exist in phage DNA is briefly discussed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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